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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for TFAP4_MSC
Z-value: 0.12
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Transcription factors associated with TFAP4_MSC
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TFAP4 | hg19_v2_chr16_-_4323015_4323076 | 0.16 | 1.5e-02 | Click! |
| MSC | hg19_v2_chr8_-_72756667_72756736 | 0.05 | 4.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TFAP4_MSC
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.9 | 59.7 | GO:0018032 | peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179) |
| 4.8 | 28.8 | GO:0070315 | G1 to G0 transition involved in cell differentiation(GO:0070315) |
| 0.4 | 26.7 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 1.3 | 24.2 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 7.0 | 20.9 | GO:1904647 | response to rotenone(GO:1904647) |
| 2.2 | 20.2 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 2.4 | 19.3 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 1.6 | 17.7 | GO:0006554 | lysine catabolic process(GO:0006554) |
| 0.5 | 15.8 | GO:0090383 | phagosome acidification(GO:0090383) |
| 3.1 | 15.7 | GO:0071874 | cellular response to norepinephrine stimulus(GO:0071874) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 64.4 | GO:0043204 | perikaryon(GO:0043204) |
| 0.6 | 47.5 | GO:0030315 | T-tubule(GO:0030315) |
| 0.1 | 28.0 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 27.6 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 1.5 | 24.2 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.4 | 22.0 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 1.9 | 19.3 | GO:0045180 | basal cortex(GO:0045180) |
| 0.4 | 18.1 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 1.7 | 15.7 | GO:1990812 | growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812) |
| 0.0 | 14.6 | GO:0000790 | nuclear chromatin(GO:0000790) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.9 | 59.7 | GO:0004598 | peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598) |
| 1.7 | 43.9 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.8 | 41.6 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.7 | 33.4 | GO:0019894 | kinesin binding(GO:0019894) |
| 2.0 | 28.2 | GO:0031432 | titin binding(GO:0031432) |
| 0.2 | 26.3 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.7 | 25.0 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.8 | 23.8 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.9 | 20.5 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 4.0 | 20.2 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 38.9 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.3 | 15.7 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.2 | 13.8 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.3 | 13.6 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.4 | 11.0 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 9.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.2 | 8.7 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 7.8 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.2 | 7.7 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.2 | 7.0 | PID RAS PATHWAY | Regulation of Ras family activation |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 16.7 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.5 | 15.8 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.8 | 15.7 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 1.1 | 14.8 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.2 | 13.6 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.4 | 12.8 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.5 | 12.5 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.4 | 11.0 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.2 | 9.5 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.1 | 9.0 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |