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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for TFEC_MITF_ARNTL_BHLHE41
Z-value: 0.11
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Transcription factors associated with TFEC_MITF_ARNTL_BHLHE41
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000105967.11 | transcription factor EC | |
| ENSG00000187098.10 | melanocyte inducing transcription factor | |
| ENSG00000133794.13 | aryl hydrocarbon receptor nuclear translocator like | |
| ENSG00000123095.5 | basic helix-loop-helix family member e41 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BHLHE41 | hg19_v2_chr12_-_26278030_26278060 | 0.34 | 1.7e-07 | Click! |
| MITF | hg19_v2_chr3_+_69788576_69788648, hg19_v2_chr3_+_69985734_69985754, hg19_v2_chr3_+_69812701_69812729, hg19_v2_chr3_+_69812877_69812962, hg19_v2_chr3_+_69928256_69928385, hg19_v2_chr3_+_69915385_69915438 | 0.31 | 2.3e-06 | Click! |
| ARNTL | hg19_v2_chr11_+_13299186_13299432 | -0.14 | 3.6e-02 | Click! |
| TFEC | hg19_v2_chr7_-_115608304_115608352, hg19_v2_chr7_-_115670804_115670867, hg19_v2_chr7_-_115670792_115670798 | -0.08 | 2.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TFEC_MITF_ARNTL_BHLHE41
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 30.7 | GO:0007035 | vacuolar acidification(GO:0007035) |
| 2.0 | 30.6 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.9 | 26.0 | GO:0006884 | cell volume homeostasis(GO:0006884) |
| 4.8 | 24.1 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 2.9 | 23.2 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 5.2 | 20.9 | GO:0043323 | regulation of natural killer cell degranulation(GO:0043321) positive regulation of natural killer cell degranulation(GO:0043323) |
| 0.2 | 20.8 | GO:0006368 | transcription elongation from RNA polymerase II promoter(GO:0006368) |
| 0.9 | 19.5 | GO:0070816 | phosphorylation of RNA polymerase II C-terminal domain(GO:0070816) |
| 1.5 | 16.6 | GO:0035751 | regulation of lysosomal lumen pH(GO:0035751) |
| 2.2 | 15.7 | GO:1902963 | regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 31.4 | GO:0005938 | cell cortex(GO:0005938) |
| 5.5 | 27.3 | GO:0000221 | vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) |
| 1.0 | 26.5 | GO:0033176 | proton-transporting V-type ATPase complex(GO:0033176) |
| 0.2 | 26.3 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 2.8 | 22.0 | GO:0097208 | alveolar lamellar body(GO:0097208) |
| 0.1 | 20.9 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 2.0 | 20.0 | GO:0000439 | core TFIIH complex(GO:0000439) |
| 0.8 | 20.0 | GO:0031082 | BLOC complex(GO:0031082) |
| 0.3 | 18.5 | GO:0016235 | aggresome(GO:0016235) |
| 2.1 | 16.6 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 44.8 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 1.9 | 30.0 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 1.3 | 29.1 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 1.0 | 20.3 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.8 | 18.8 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.4 | 18.2 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.2 | 16.7 | GO:0019905 | syntaxin binding(GO:0019905) |
| 1.3 | 15.7 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 2.9 | 14.5 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 0.1 | 14.3 | GO:0001618 | virus receptor activity(GO:0001618) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 38.3 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 1.0 | 18.8 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.3 | 18.2 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.4 | 12.3 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 10.9 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.3 | 10.5 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.3 | 10.4 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.2 | 10.4 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 8.9 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.2 | 8.6 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 49.3 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.3 | 27.8 | REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE | Genes involved in Cell death signalling via NRAGE, NRIF and NADE |
| 0.5 | 23.0 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.2 | 19.2 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.6 | 17.5 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.3 | 16.2 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.3 | 13.0 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.4 | 11.4 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 11.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.4 | 11.2 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |