Project
GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for TGIF1
Z-value: 1.03
Motif logo
Transcription factors associated with TGIF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TGIF1 | hg19_v2_chr18_+_3451646_3451722 | -0.69 | 8.8e-32 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TGIF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.7 | 120.0 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 2.3 | 70.9 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 3.9 | 61.9 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.2 | 56.6 | GO:0002244 | hematopoietic progenitor cell differentiation(GO:0002244) |
| 1.4 | 56.2 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 6.2 | 43.2 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 3.2 | 35.6 | GO:2000580 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 3.5 | 35.1 | GO:0051612 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 2.1 | 29.8 | GO:0047484 | regulation of response to osmotic stress(GO:0047484) |
| 8.3 | 25.0 | GO:2000854 | positive regulation of corticosterone secretion(GO:2000854) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.5 | 120.0 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.4 | 67.5 | GO:0030426 | growth cone(GO:0030426) |
| 0.4 | 63.1 | GO:0044853 | plasma membrane raft(GO:0044853) |
| 0.5 | 50.0 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.6 | 38.9 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.1 | 38.4 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.2 | 35.9 | GO:0045121 | membrane raft(GO:0045121) |
| 1.2 | 35.6 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.4 | 30.7 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.8 | 29.2 | GO:0097542 | ciliary tip(GO:0097542) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 120.0 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 2.4 | 55.6 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 3.3 | 43.2 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 1.1 | 41.3 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 3.3 | 36.1 | GO:0008430 | selenium binding(GO:0008430) |
| 1.8 | 35.6 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 2.2 | 30.3 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 6.1 | 24.5 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
| 1.7 | 23.7 | GO:0031432 | titin binding(GO:0031432) |
| 0.7 | 22.6 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 55.3 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.8 | 38.6 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.6 | 28.6 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 0.5 | 25.9 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.7 | 24.5 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.2 | 21.9 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 21.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.7 | 20.8 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.4 | 20.7 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.6 | 20.3 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 54.3 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 1.8 | 53.1 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.6 | 41.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 2.3 | 22.6 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.6 | 21.8 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.6 | 20.6 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.1 | 20.0 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.4 | 17.6 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.5 | 16.8 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 1.4 | 15.8 | REACTOME OPSINS | Genes involved in Opsins |