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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for THRA_RXRB
Z-value: 0.19
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Transcription factors associated with THRA_RXRB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| THRA | hg19_v2_chr17_+_38219063_38219154 | -0.40 | 6.4e-10 | Click! |
| RXRB | hg19_v2_chr6_-_33168391_33168465 | -0.03 | 7.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_+_23264766 Show fit | 47.23 |
ENST00000390331.2
|
immunoglobulin lambda constant 7 |
|
| chr14_-_106054659 Show fit | 33.86 |
ENST00000390539.2
|
immunoglobulin heavy constant alpha 2 (A2m marker) |
|
| chr22_+_23165153 Show fit | 22.82 |
ENST00000390317.2
|
immunoglobulin lambda variable 2-8 |
|
| chr22_+_23134974 Show fit | 18.64 |
ENST00000390314.2
|
immunoglobulin lambda variable 2-11 |
|
| chr19_-_39826639 Show fit | 18.38 |
ENST00000602185.1
ENST00000598034.1 ENST00000601387.1 ENST00000595636.1 ENST00000253054.8 ENST00000594700.1 ENST00000597595.1 |
glia maturation factor, gamma |
|
| chr14_-_106174960 Show fit | 17.96 |
ENST00000390547.2
|
immunoglobulin heavy constant alpha 1 |
|
| chr22_+_23243156 Show fit | 16.40 |
ENST00000390323.2
|
immunoglobulin lambda constant 2 (Kern-Oz- marker) |
|
| chr22_+_23077065 Show fit | 15.38 |
ENST00000390310.2
|
immunoglobulin lambda variable 2-18 |
|
| chr16_+_85942594 Show fit | 14.93 |
ENST00000566369.1
|
interferon regulatory factor 8 |
|
| chr19_-_10450328 Show fit | 14.65 |
ENST00000160262.5
|
intercellular adhesion molecule 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of THRA_RXRB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 122.8 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 5.2 | 51.8 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 0.2 | 41.5 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.2 | 29.3 | GO:0002223 | stimulatory C-type lectin receptor signaling pathway(GO:0002223) |
| 3.0 | 21.3 | GO:1901314 | negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915) |
| 0.9 | 20.7 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 2.6 | 18.4 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 0.7 | 14.9 | GO:0044130 | negative regulation of growth of symbiont in host(GO:0044130) |
| 0.0 | 13.9 | GO:0002250 | adaptive immune response(GO:0002250) |
| 0.0 | 10.7 | GO:0030323 | respiratory tube development(GO:0030323) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 52.4 | GO:0005576 | extracellular region(GO:0005576) |
| 17.3 | 51.8 | GO:0071746 | IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751) |
| 1.0 | 47.2 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.4 | 28.2 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 21.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 18.9 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 15.8 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.5 | 9.6 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.3 | 8.9 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.6 | 8.6 | GO:0070578 | RISC-loading complex(GO:0070578) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 114.3 | GO:0003823 | antigen binding(GO:0003823) |
| 1.8 | 99.1 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.2 | 33.2 | GO:0005178 | integrin binding(GO:0005178) |
| 0.4 | 19.3 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 2.3 | 18.4 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.1 | 18.3 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 2.3 | 18.2 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
| 0.1 | 10.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.7 | 8.7 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 1.0 | 8.6 | GO:0070883 | pre-miRNA binding(GO:0070883) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 27.4 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 17.8 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.2 | 14.9 | PID GMCSF PATHWAY | GMCSF-mediated signaling events |
| 0.2 | 12.6 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.2 | 7.1 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.5 | 6.8 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 6.6 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 5.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.2 | 5.1 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.1 | 4.8 | PID MYC PATHWAY | C-MYC pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 29.1 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 26.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.3 | 21.1 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.2 | 14.9 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.2 | 8.9 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.2 | 8.0 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.3 | 6.8 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.1 | 6.5 | REACTOME ASPARAGINE N LINKED GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |
| 0.2 | 6.0 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.1 | 5.8 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |