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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for THRA_RXRB

Z-value: 0.19

Motif logo

Transcription factors associated with THRA_RXRB

Gene Symbol Gene ID Gene Info
ENSG00000126351.8 thyroid hormone receptor alpha
ENSG00000204231.6 retinoid X receptor beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
THRAhg19_v2_chr17_+_38219063_38219154-0.406.4e-10Click!
RXRBhg19_v2_chr6_-_33168391_33168465-0.037.0e-01Click!

Activity profile of THRA_RXRB motif

Sorted Z-values of THRA_RXRB motif

Promoter Log-likelihood Transcript Gene Gene Info
chr22_+_23264766 47.23 ENST00000390331.2
immunoglobulin lambda constant 7
chr14_-_106054659 33.86 ENST00000390539.2
immunoglobulin heavy constant alpha 2 (A2m marker)
chr22_+_23165153 22.82 ENST00000390317.2
immunoglobulin lambda variable 2-8
chr22_+_23134974 18.64 ENST00000390314.2
immunoglobulin lambda variable 2-11
chr19_-_39826639 18.38 ENST00000602185.1
ENST00000598034.1
ENST00000601387.1
ENST00000595636.1
ENST00000253054.8
ENST00000594700.1
ENST00000597595.1
glia maturation factor, gamma
chr14_-_106174960 17.96 ENST00000390547.2
immunoglobulin heavy constant alpha 1
chr22_+_23243156 16.40 ENST00000390323.2
immunoglobulin lambda constant 2 (Kern-Oz- marker)
chr22_+_23077065 15.38 ENST00000390310.2
immunoglobulin lambda variable 2-18
chr16_+_85942594 14.93 ENST00000566369.1
interferon regulatory factor 8
chr19_-_10450328 14.65 ENST00000160262.5
intercellular adhesion molecule 3
chr19_-_10450287 12.75 ENST00000589261.1
ENST00000590569.1
ENST00000589580.1
ENST00000589249.1
intercellular adhesion molecule 3
chr2_-_230786679 12.18 ENST00000543084.1
ENST00000343290.5
ENST00000389044.4
ENST00000283943.5
thyroid hormone receptor interactor 12
chr22_+_22681656 11.83 ENST00000390291.2
immunoglobulin lambda variable 1-50 (non-functional)
chr22_+_22712087 11.38 ENST00000390294.2
immunoglobulin lambda variable 1-47
chr6_+_139456226 10.76 ENST00000367658.2
headcase homolog (Drosophila)
chr22_+_23040274 10.64 ENST00000390306.2
immunoglobulin lambda variable 2-23
chr22_+_22764088 9.41 ENST00000390299.2
immunoglobulin lambda variable 1-40
chr2_-_230786619 9.09 ENST00000389045.3
ENST00000409677.1
thyroid hormone receptor interactor 12
chr1_-_149900122 8.87 ENST00000271628.8
splicing factor 3b, subunit 4, 49kDa
chr19_+_1065922 8.21 ENST00000539243.2
histocompatibility (minor) HA-1
chrX_-_152989798 7.79 ENST00000441714.1
ENST00000442093.1
ENST00000429550.1
ENST00000345046.6
B-cell receptor-associated protein 31
chr14_-_55369525 7.61 ENST00000543643.2
ENST00000536224.2
ENST00000395514.1
ENST00000491895.2
GTP cyclohydrolase 1
chr2_+_87565634 7.30 ENST00000421835.2
immunoglobulin kappa variable 3/OR2-268 (non-functional)
chr19_+_49838653 7.15 ENST00000598095.1
ENST00000426897.2
ENST00000323906.4
ENST00000535669.2
ENST00000597602.1
ENST00000595660.1
CD37 molecule
chr13_-_41635512 7.14 ENST00000405737.2
E74-like factor 1 (ets domain transcription factor)
chr2_-_90538397 7.10 ENST00000443397.3
Uncharacterized protein
chr2_+_90153696 7.06 ENST00000417279.2
immunoglobulin kappa variable 3D-15 (gene/pseudogene)
chr5_-_149829314 6.93 ENST00000407193.1
ribosomal protein S14
chr2_-_176046391 6.81 ENST00000392541.3
ENST00000409194.1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
chr5_-_149829294 6.70 ENST00000401695.3
ribosomal protein S14
chr13_+_76123883 6.07 ENST00000377595.3
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
chr16_+_85646763 5.99 ENST00000411612.1
ENST00000253458.7
Gse1 coiled-coil protein
chr13_-_46756351 5.98 ENST00000323076.2
lymphocyte cytosolic protein 1 (L-plastin)
chr1_+_41204506 5.95 ENST00000525290.1
ENST00000530965.1
ENST00000416859.2
ENST00000308733.5
nuclear transcription factor Y, gamma
chr22_-_36784035 5.92 ENST00000216181.5
myosin, heavy chain 9, non-muscle
chr11_-_58343319 5.36 ENST00000395074.2
leupaxin
chr12_-_102513843 5.31 ENST00000551744.2
ENST00000552283.1
nucleoporin 37kDa
chr14_-_104028595 5.16 ENST00000337322.4
ENST00000445922.2
BCL2-associated athanogene 5
chr5_-_180666570 5.10 ENST00000509535.1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
chr20_+_43343886 5.05 ENST00000190983.4
WNT1 inducible signaling pathway protein 2
chr14_-_58893832 5.04 ENST00000556007.2
translocase of inner mitochondrial membrane 9 homolog (yeast)
chr14_+_22963806 4.93 ENST00000390493.1
T cell receptor alpha joining 44
chr3_-_127872625 4.84 ENST00000464873.1
RuvB-like AAA ATPase 1
chr13_-_95131923 4.65 ENST00000377028.5
ENST00000446125.1
dopachrome tautomerase
chr17_-_18161870 4.63 ENST00000579294.1
ENST00000545457.2
ENST00000379450.4
ENST00000578558.1
flightless I homolog (Drosophila)
chr22_+_22676808 4.60 ENST00000390290.2
immunoglobulin lambda variable 1-51
chr5_-_149829244 4.55 ENST00000312037.5
ribosomal protein S14
chrX_-_129299638 4.05 ENST00000535724.1
ENST00000346424.2
apoptosis-inducing factor, mitochondrion-associated, 1
chr9_-_139305051 3.96 ENST00000371725.3
ENST00000298537.7
serologically defined colon cancer antigen 3
chr17_+_8191815 3.72 ENST00000226105.6
ENST00000407006.4
ENST00000580434.1
ENST00000439238.3
RAN guanine nucleotide release factor
chr3_-_195270162 3.61 ENST00000438848.1
ENST00000328432.3
protein phosphatase 1, regulatory (inhibitor) subunit 2
chr19_+_6739662 3.58 ENST00000313285.8
ENST00000313244.9
ENST00000596758.1
thyroid hormone receptor interactor 10
chr20_+_3776371 3.58 ENST00000245960.5
cell division cycle 25B
chr14_-_104029013 3.56 ENST00000299204.4
ENST00000557666.1
BCL2-associated athanogene 5
chr6_+_21593972 3.52 ENST00000244745.1
ENST00000543472.1
SRY (sex determining region Y)-box 4
chr22_-_21581926 3.44 ENST00000401924.1
gamma-glutamyltransferase 2
chr14_-_24616426 3.37 ENST00000216802.5
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr12_+_56211703 3.33 ENST00000243045.5
ENST00000552672.1
ENST00000550836.1
ORM1-like 2 (S. cerevisiae)
chr1_+_155583012 3.30 ENST00000462250.2
misato 1, mitochondrial distribution and morphology regulator
chr20_+_3776936 3.24 ENST00000439880.2
cell division cycle 25B
chr7_+_5085452 3.23 ENST00000353796.3
ENST00000396912.1
ENST00000396904.2
RB-associated KRAB zinc finger
RBAK-RBAKDN readthrough
chr2_-_179315786 3.07 ENST00000457633.1
ENST00000438687.3
ENST00000325748.4
protein kinase, interferon-inducible double stranded RNA dependent activator
chr20_+_35807512 2.98 ENST00000373622.5
ribophorin II
chr9_+_116298778 2.94 ENST00000462143.1
regulator of G-protein signaling 3
chr2_-_179315490 2.92 ENST00000487082.1
protein kinase, interferon-inducible double stranded RNA dependent activator
chr20_+_35807449 2.92 ENST00000237530.6
ribophorin II
chr22_-_29137771 2.91 ENST00000439200.1
ENST00000405598.1
ENST00000398017.2
ENST00000425190.2
ENST00000348295.3
ENST00000382578.1
ENST00000382565.1
ENST00000382566.1
ENST00000382580.2
ENST00000328354.6
checkpoint kinase 2
chr16_+_3074002 2.80 ENST00000326266.8
ENST00000574549.1
ENST00000575576.1
ENST00000253952.9
THO complex 6 homolog (Drosophila)
chr1_+_45212074 2.76 ENST00000372217.1
kinesin family member 2C
chr17_+_27071002 2.73 ENST00000262395.5
ENST00000422344.1
ENST00000444415.3
ENST00000262396.6
TNF receptor-associated factor 4
chr2_+_55459495 2.70 ENST00000272317.6
ENST00000449323.1
ribosomal protein S27a
chr9_+_36572851 2.64 ENST00000298048.2
ENST00000538311.1
ENST00000536987.1
ENST00000545008.1
ENST00000536860.1
ENST00000536329.1
ENST00000541717.1
ENST00000543751.1
maternal embryonic leucine zipper kinase
chrX_+_9431324 2.62 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
transducin (beta)-like 1X-linked
chr2_-_179315453 2.57 ENST00000432031.2
protein kinase, interferon-inducible double stranded RNA dependent activator
chr19_+_58898627 2.56 ENST00000598098.1
ENST00000598495.1
ENST00000196551.3
ENST00000596046.1
ribosomal protein S5
chr14_-_24036943 2.55 ENST00000556843.1
ENST00000397120.3
ENST00000557189.1
adaptor-related protein complex 1, gamma 2 subunit
chr9_+_131452239 2.54 ENST00000372688.4
ENST00000372686.5
SET nuclear oncogene
chr1_+_45212051 2.52 ENST00000372222.3
kinesin family member 2C
chr2_-_183387283 2.51 ENST00000435564.1
phosphodiesterase 1A, calmodulin-dependent
chr16_+_85646891 2.48 ENST00000393243.1
Gse1 coiled-coil protein
chr18_+_19749386 2.48 ENST00000269216.3
GATA binding protein 6
chr8_+_103563792 2.47 ENST00000285402.3
outer dense fiber of sperm tails 1
chr8_+_110552831 2.47 ENST00000530629.1
estrogen receptor binding site associated, antigen, 9
chr11_-_5531215 2.43 ENST00000311659.4
ubiquilin 3
chr1_+_203274639 2.40 ENST00000290551.4
BTG family, member 2
chr18_+_3262954 2.38 ENST00000584539.1
myosin, light chain 12B, regulatory
chr1_-_175162048 2.38 ENST00000444639.1
KIAA0040
chr7_+_73245193 2.33 ENST00000340958.2
claudin 4
chr17_-_41132010 2.32 ENST00000409103.1
ENST00000360221.4
PTGES3L-AARSD1 readthrough
chr9_+_117350009 2.31 ENST00000374050.3
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
chr9_+_139305102 2.29 ENST00000371720.1
ENST00000371717.3
ENST00000399219.3
peptidase (mitochondrial processing) alpha
chr1_-_151431647 2.23 ENST00000368863.2
ENST00000409503.1
ENST00000491586.1
ENST00000533351.1
ENST00000540984.1
pogo transposable element with ZNF domain
chr9_+_34652164 2.19 ENST00000441545.2
ENST00000553620.1
interleukin 11 receptor, alpha
chr17_-_5389477 2.17 ENST00000572834.1
ENST00000570848.1
ENST00000571971.1
ENST00000158771.4
derlin 2
chr15_-_75230368 2.17 ENST00000564811.1
ENST00000562233.1
ENST00000567270.1
ENST00000568783.1
cytochrome c oxidase subunit Va
chr7_-_140179276 2.16 ENST00000443720.2
ENST00000255977.2
makorin ring finger protein 1
chr3_+_184038073 2.09 ENST00000428387.1
ENST00000434061.2
eukaryotic translation initiation factor 4 gamma, 1
chr1_+_93544821 2.09 ENST00000370303.4
metal response element binding transcription factor 2
chr1_-_33815486 2.07 ENST00000373418.3
polyhomeotic homolog 2 (Drosophila)
chr15_+_44084503 2.03 ENST00000409960.2
ENST00000409646.1
ENST00000594896.1
ENST00000339624.5
ENST00000409291.1
ENST00000402131.1
ENST00000403425.1
ENST00000430901.1
small EDRK-rich factor 2
chr3_+_25831567 1.96 ENST00000280701.3
ENST00000420173.2
3-oxoacyl-ACP synthase, mitochondrial
chr10_+_81107271 1.91 ENST00000448165.1
peptidylprolyl isomerase F
chr10_+_11207438 1.90 ENST00000609692.1
ENST00000354897.3
CUGBP, Elav-like family member 2
chr11_-_59578202 1.88 ENST00000300151.4
mitochondrial ribosomal protein L16
chr2_+_86426478 1.87 ENST00000254644.8
ENST00000605125.1
ENST00000337109.4
ENST00000409180.1
mitochondrial ribosomal protein L35
chr11_+_117049854 1.86 ENST00000278951.7
SID1 transmembrane family, member 2
chr15_+_44084040 1.82 ENST00000249786.4
small EDRK-rich factor 2
chr5_+_139927213 1.79 ENST00000310331.2
eukaryotic translation initiation factor 4E binding protein 3
chr9_-_139304979 1.79 ENST00000357365.3
ENST00000371723.4
serologically defined colon cancer antigen 3
chr1_-_103574024 1.79 ENST00000512756.1
ENST00000370096.3
ENST00000358392.2
ENST00000353414.4
collagen, type XI, alpha 1
chr2_-_183387430 1.77 ENST00000410103.1
phosphodiesterase 1A, calmodulin-dependent
chr22_+_30163340 1.76 ENST00000330029.6
ENST00000401406.3
ubiquinol-cytochrome c reductase, complex III subunit X
chr6_+_43457317 1.75 ENST00000438588.2
tight junction associated protein 1 (peripheral)
chr2_-_100106419 1.73 ENST00000393445.3
ENST00000258428.3
REV1, polymerase (DNA directed)
chr11_-_64013663 1.72 ENST00000392210.2
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr19_-_40228657 1.68 ENST00000221804.4
Charcot-Leyden crystal galectin
chr11_+_122709200 1.67 ENST00000227348.4
cytotoxic and regulatory T cell molecule
chr2_-_192016316 1.63 ENST00000358470.4
ENST00000432798.1
ENST00000450994.1
signal transducer and activator of transcription 4
chr17_-_41132410 1.60 ENST00000409446.3
ENST00000453594.1
ENST00000409399.1
ENST00000421990.2
prostaglandin E synthase 3 (cytosolic)-like
PTGES3L-AARSD1 readthrough
chr3_+_184037466 1.60 ENST00000441154.1
eukaryotic translation initiation factor 4 gamma, 1
chr11_+_71935797 1.59 ENST00000298229.2
ENST00000541756.1
inositol polyphosphate phosphatase-like 1
chr19_+_16186903 1.58 ENST00000588507.1
tropomyosin 4
chr19_+_39989535 1.57 ENST00000356433.5
delta-like 3 (Drosophila)
chr11_+_7618413 1.57 ENST00000528883.1
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr2_-_183387064 1.56 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
phosphodiesterase 1A, calmodulin-dependent
chr19_-_52227221 1.55 ENST00000222115.1
ENST00000540069.2
hyaluronan synthase 1
chr22_-_29138386 1.54 ENST00000544772.1
checkpoint kinase 2
chr10_+_75757863 1.52 ENST00000372755.3
ENST00000211998.4
ENST00000417648.2
vinculin
chr10_+_104178946 1.50 ENST00000432590.1
F-box and leucine-rich repeat protein 15
chr10_+_11784360 1.47 ENST00000379215.4
ENST00000420401.1
enoyl CoA hydratase domain containing 3
chr1_+_55107449 1.44 ENST00000421030.2
ENST00000545244.1
ENST00000339553.5
ENST00000409996.1
ENST00000454855.2
maestro heat-like repeat family member 7
chr12_-_114843889 1.37 ENST00000405440.2
T-box 5
chr14_+_81421921 1.37 ENST00000554263.1
ENST00000554435.1
thyroid stimulating hormone receptor
chr4_-_151936416 1.36 ENST00000510413.1
ENST00000507224.1
LPS-responsive vesicle trafficking, beach and anchor containing
chr12_+_52626898 1.30 ENST00000331817.5
keratin 7
chr2_+_45168875 1.30 ENST00000260653.3
SIX homeobox 3
chr2_+_201936707 1.30 ENST00000433898.1
ENST00000454214.1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
chr14_+_81421861 1.30 ENST00000298171.2
thyroid stimulating hormone receptor
chr16_-_47007545 1.29 ENST00000317089.5
DnaJ (Hsp40) homolog, subfamily A, member 2
chrX_-_39956656 1.28 ENST00000397354.3
ENST00000378444.4
BCL6 corepressor
chr15_-_34629922 1.28 ENST00000559484.1
ENST00000354181.3
ENST00000558589.1
ENST00000458406.2
solute carrier family 12 (potassium/chloride transporter), member 6
chr7_+_100187196 1.28 ENST00000468962.1
ENST00000427939.2
F-box protein 24
chr15_-_75017711 1.27 ENST00000567032.1
ENST00000564596.1
ENST00000566503.1
ENST00000395049.4
ENST00000395048.2
ENST00000379727.3
cytochrome P450, family 1, subfamily A, polypeptide 1
chr14_+_22964877 1.24 ENST00000390494.1
T cell receptor alpha joining 43
chr17_-_80231557 1.19 ENST00000392334.2
ENST00000314028.6
casein kinase 1, delta
chr17_+_34171081 1.18 ENST00000585577.1
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
chr22_-_24316648 1.17 ENST00000403754.3
ENST00000430101.2
ENST00000398344.4
D-dopachrome tautomerase
chr1_-_155880672 1.14 ENST00000609492.1
ENST00000368322.3
Ras-like without CAAX 1
chr22_+_38245414 1.13 ENST00000381683.6
ENST00000414316.1
ENST00000406934.1
ENST00000451427.1
eukaryotic translation initiation factor 3, subunit L
chr3_-_187009798 1.13 ENST00000337774.5
mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
chr3_+_179322481 1.12 ENST00000259037.3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
chr6_-_99797522 1.10 ENST00000389677.5
failed axon connections homolog (Drosophila)
chr14_+_81421710 1.07 ENST00000342443.6
thyroid stimulating hormone receptor
chr2_+_55459808 1.05 ENST00000404735.1
ribosomal protein S27a
chr9_+_127631399 1.05 ENST00000259477.6
actin related protein 2/3 complex, subunit 5-like
chr15_-_31393910 0.99 ENST00000397795.2
ENST00000256552.6
ENST00000559179.1
transient receptor potential cation channel, subfamily M, member 1
chr19_+_41117770 0.96 ENST00000601032.1
latent transforming growth factor beta binding protein 4
chr3_+_49058444 0.96 ENST00000326925.6
ENST00000395458.2
NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
chr11_+_111896320 0.95 ENST00000531306.1
ENST00000537636.1
dihydrolipoamide S-acetyltransferase
chr1_-_85040090 0.94 ENST00000370630.5
chitobiase, di-N-acetyl-
chr17_-_4843206 0.94 ENST00000576951.1
solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
chr3_-_15374659 0.93 ENST00000426925.1
SH3-domain binding protein 5 (BTK-associated)
chr1_+_236558694 0.91 ENST00000359362.5
EDAR-associated death domain
chr1_+_93544791 0.87 ENST00000545708.1
ENST00000540243.1
ENST00000370298.4
metal response element binding transcription factor 2
chr11_-_30607819 0.87 ENST00000448418.2
metallophosphoesterase domain containing 2
chr11_+_65190245 0.87 ENST00000499732.1
ENST00000501122.2
ENST00000601801.1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr19_+_49866331 0.87 ENST00000597873.1
dickkopf-like 1
chr1_-_174992544 0.86 ENST00000476371.1
mitochondrial ribosomal protein S14
chr11_-_62752162 0.86 ENST00000458333.2
ENST00000421062.2
solute carrier family 22 (organic anion transporter), member 6
chr3_+_179322573 0.84 ENST00000493866.1
ENST00000472629.1
ENST00000482604.1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
chr14_-_25078864 0.81 ENST00000216338.4
ENST00000557220.2
ENST00000382548.4
granzyme H (cathepsin G-like 2, protein h-CCPX)
chr10_-_76859247 0.80 ENST00000472493.2
ENST00000605915.1
ENST00000478873.2
dual specificity phosphatase 13
chr1_+_22962948 0.80 ENST00000374642.3
complement component 1, q subcomponent, A chain
chr2_-_68479614 0.79 ENST00000234310.3
protein phosphatase 3, regulatory subunit B, alpha
chr1_-_151431909 0.78 ENST00000361398.3
ENST00000271715.2
pogo transposable element with ZNF domain
chr17_+_37894179 0.76 ENST00000577695.1
ENST00000309156.4
ENST00000309185.3
growth factor receptor-bound protein 7
chr19_-_45826125 0.75 ENST00000221476.3
creatine kinase, muscle
chr9_+_125133315 0.73 ENST00000223423.4
ENST00000362012.2
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr1_-_175161890 0.73 ENST00000545251.2
ENST00000423313.1
KIAA0040
chr11_+_66624527 0.72 ENST00000393952.3
leucine rich repeat and fibronectin type III domain containing 4
chr11_-_119599794 0.70 ENST00000264025.3
poliovirus receptor-related 1 (herpesvirus entry mediator C)
chr7_-_73153122 0.70 ENST00000458339.1
abhydrolase domain containing 11
chr18_+_12948000 0.70 ENST00000585730.1
ENST00000399892.2
ENST00000589446.1
ENST00000587761.1
SEH1-like (S. cerevisiae)
chr5_+_162887556 0.69 ENST00000393915.4
ENST00000432118.2
ENST00000358715.3
hyaluronan-mediated motility receptor (RHAMM)
chr19_+_16187085 0.68 ENST00000300933.4
tropomyosin 4
chr19_+_39989580 0.67 ENST00000596614.1
ENST00000205143.4
delta-like 3 (Drosophila)
chr2_-_49381646 0.67 ENST00000346173.3
ENST00000406846.2
follicle stimulating hormone receptor
chr7_-_150777949 0.67 ENST00000482571.1
Fas-activated serine/threonine kinase
chr2_-_49381572 0.66 ENST00000454032.1
ENST00000304421.4
follicle stimulating hormone receptor
chr3_-_38691119 0.63 ENST00000333535.4
ENST00000413689.1
ENST00000443581.1
ENST00000425664.1
ENST00000451551.2
sodium channel, voltage-gated, type V, alpha subunit
chr6_+_30131318 0.63 ENST00000376688.1
tripartite motif containing 15
chrX_+_70521584 0.62 ENST00000373829.3
ENST00000538820.1
integrin beta 1 binding protein (melusin) 2
chr5_-_176981417 0.62 ENST00000514747.1
ENST00000443375.2
ENST00000329540.5
family with sequence similarity 193, member B
chr3_-_197024965 0.62 ENST00000392382.2
discs, large homolog 1 (Drosophila)
chr3_-_46000064 0.61 ENST00000433878.1
FYVE and coiled-coil domain containing 1
chr22_+_41075277 0.61 ENST00000381433.2
melanin-concentrating hormone receptor 1
chr2_-_165698521 0.61 ENST00000409184.3
ENST00000392717.2
ENST00000456693.1
cordon-bleu WH2 repeat protein-like 1
chr11_+_64879317 0.59 ENST00000526809.1
ENST00000279263.7
ENST00000524986.1
ENST00000534371.1
ENST00000540748.1
ENST00000525385.1
ENST00000345348.5
ENST00000531321.1
ENST00000529414.1
ENST00000526085.1
ENST00000530750.1
transmembrane 7 superfamily member 2
chr5_+_112849373 0.58 ENST00000161863.4
ENST00000515883.1
YTH domain containing 2
chr1_-_17380630 0.57 ENST00000375499.3
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

Network of associatons between targets according to the STRING database.

First level regulatory network of THRA_RXRB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 51.8 GO:0060267 positive regulation of respiratory burst(GO:0060267)
3.0 21.3 GO:1901314 negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915)
2.6 18.4 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
2.5 7.6 GO:0051066 dihydrobiopterin metabolic process(GO:0051066)
2.0 5.9 GO:0051295 establishment of meiotic spindle localization(GO:0051295)
1.6 7.8 GO:1904154 positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
1.5 4.5 GO:1903926 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
1.5 8.7 GO:0061084 regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084)
1.1 3.3 GO:0090155 negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060)
0.9 20.7 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.9 3.7 GO:1905229 cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229)
0.9 3.7 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
0.9 3.5 GO:0035910 N-terminal peptidyl-lysine acetylation(GO:0018076) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.9 122.8 GO:0030449 regulation of complement activation(GO:0030449)
0.8 2.5 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
0.7 14.9 GO:0044130 negative regulation of growth of symbiont in host(GO:0044130)
0.7 6.8 GO:0007144 female meiosis I(GO:0007144)
0.7 5.4 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.7 4.7 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.7 8.6 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.6 1.9 GO:2000276 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445) negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276)
0.6 4.1 GO:1904044 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650) response to aldosterone(GO:1904044)
0.6 2.3 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.6 5.0 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.5 5.3 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.5 3.0 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.5 1.4 GO:0003218 cardiac left ventricle formation(GO:0003218)
0.4 1.3 GO:0021798 neuroblast differentiation(GO:0014016) forebrain dorsal/ventral pattern formation(GO:0021798) regulation of neural retina development(GO:0061074) regulation of retina development in camera-type eye(GO:1902866)
0.4 1.3 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.4 1.3 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894) cellular alkene metabolic process(GO:0043449)
0.4 8.2 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.4 3.7 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
0.4 1.6 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.4 1.2 GO:1901253 negative regulation of intracellular transport of viral material(GO:1901253)
0.4 2.2 GO:0007386 compartment pattern specification(GO:0007386)
0.4 4.8 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.3 5.8 GO:0046069 cGMP catabolic process(GO:0046069)
0.3 1.3 GO:0001545 primary ovarian follicle growth(GO:0001545)
0.3 1.9 GO:0015742 alpha-ketoglutarate transport(GO:0015742)
0.3 2.8 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.3 2.2 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.3 6.0 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.3 1.8 GO:0035989 tendon development(GO:0035989)
0.3 7.1 GO:0050858 negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.3 2.7 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.3 4.6 GO:0051014 actin filament severing(GO:0051014)
0.3 5.8 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.2 41.5 GO:0002377 immunoglobulin production(GO:0002377)
0.2 3.4 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.2 1.7 GO:0002420 natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.2 3.0 GO:0051382 kinetochore assembly(GO:0051382)
0.2 1.8 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.2 6.8 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.2 1.7 GO:0002667 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.2 3.3 GO:0048311 mitochondrion distribution(GO:0048311)
0.2 5.5 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.2 0.4 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.2 2.0 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.2 29.3 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.2 1.9 GO:0033227 dsRNA transport(GO:0033227)
0.2 0.6 GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.2 2.4 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.1 0.9 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.1 0.4 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.1 1.1 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.1 6.0 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 1.5 GO:0010764 negative regulation of fibroblast migration(GO:0010764)
0.1 0.9 GO:0008154 actin polymerization or depolymerization(GO:0008154) actin filament polymerization(GO:0030041)
0.1 0.3 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.1 0.6 GO:1901098 regulation of autophagosome maturation(GO:1901096) positive regulation of autophagosome maturation(GO:1901098)
0.1 6.5 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.1 2.5 GO:0006337 nucleosome disassembly(GO:0006337)
0.1 5.5 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.1 0.3 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.1 4.0 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.1 0.3 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.1 0.9 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.1 1.5 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.1 2.3 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 1.8 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.1 1.5 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.1 0.3 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.1 0.7 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 4.9 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.1 0.8 GO:0006600 creatine metabolic process(GO:0006600)
0.1 0.5 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.1 1.5 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 1.1 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1 0.6 GO:0006105 succinate metabolic process(GO:0006105)
0.1 1.2 GO:0071539 protein localization to centrosome(GO:0071539)
0.1 1.0 GO:0046548 retinal rod cell development(GO:0046548)
0.1 1.6 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 1.9 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 0.6 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 10.7 GO:0030323 respiratory tube development(GO:0030323)
0.0 2.6 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.0 3.2 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 13.9 GO:0002250 adaptive immune response(GO:0002250)
0.0 0.9 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 1.2 GO:0006582 melanin metabolic process(GO:0006582) melanin biosynthetic process(GO:0042438)
0.0 0.7 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 0.6 GO:0034063 stress granule assembly(GO:0034063)
0.0 1.0 GO:0030252 growth hormone secretion(GO:0030252)
0.0 0.7 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.2 GO:0016050 vesicle organization(GO:0016050)
0.0 0.2 GO:0006581 acetylcholine catabolic process in synaptic cleft(GO:0001507) acetylcholine catabolic process(GO:0006581)
0.0 0.3 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.0 1.0 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.1 GO:0046549 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 2.1 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 1.3 GO:0007566 embryo implantation(GO:0007566)
0.0 0.3 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.8 GO:0019835 cytolysis(GO:0019835)
0.0 0.5 GO:0061014 positive regulation of mRNA catabolic process(GO:0061014)
0.0 0.4 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.4 GO:0008299 isoprenoid biosynthetic process(GO:0008299)
0.0 2.1 GO:0016575 histone deacetylation(GO:0016575)
0.0 0.8 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.0 0.5 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.4 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.9 GO:0035722 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.0 0.4 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.0 0.2 GO:0051005 nerve growth factor signaling pathway(GO:0038180) plasma membrane to endosome transport(GO:0048227) negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.2 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 1.8 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.5 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.1 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
17.3 51.8 GO:0071746 IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751)
2.0 5.9 GO:0005826 actomyosin contractile ring(GO:0005826)
1.3 7.8 GO:0071256 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
1.3 5.0 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
1.0 47.2 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.8 3.3 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.6 8.6 GO:0070578 RISC-loading complex(GO:0070578)
0.6 3.4 GO:0008537 proteasome activator complex(GO:0008537)
0.5 6.0 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.5 5.9 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.5 4.8 GO:0097255 R2TP complex(GO:0097255)
0.5 9.6 GO:0001891 phagocytic cup(GO:0001891)
0.4 1.3 GO:0031519 PcG protein complex(GO:0031519)
0.4 6.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.4 28.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.4 6.0 GO:0031080 nuclear pore outer ring(GO:0031080)
0.4 2.5 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.3 8.9 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.3 2.2 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.3 2.2 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.3 1.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.3 5.8 GO:0030904 retromer complex(GO:0030904)
0.3 4.7 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.2 1.0 GO:0035838 growing cell tip(GO:0035838)
0.2 3.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 1.5 GO:0001520 outer dense fiber(GO:0001520)
0.2 8.2 GO:0002102 podosome(GO:0002102)
0.2 1.8 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.2 0.8 GO:0005602 complement component C1 complex(GO:0005602)
0.2 4.4 GO:0035371 microtubule plus-end(GO:0035371)
0.1 1.8 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.6 GO:0045257 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.1 1.9 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.1 21.7 GO:0072562 blood microparticle(GO:0072562)
0.1 3.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 1.8 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 6.7 GO:0001772 immunological synapse(GO:0001772)
0.1 3.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 1.5 GO:0035102 PRC1 complex(GO:0035102)
0.1 0.3 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 0.5 GO:0001652 granular component(GO:0001652)
0.1 3.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 0.8 GO:0005955 calcineurin complex(GO:0005955)
0.1 15.8 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.1 2.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 2.4 GO:0099738 cell cortex region(GO:0099738)
0.1 1.6 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.1 1.0 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 3.8 GO:0005876 spindle microtubule(GO:0005876)
0.1 0.4 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.4 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.1 0.6 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.4 GO:0005787 signal peptidase complex(GO:0005787)
0.1 4.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.1 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.1 GO:0005879 axonemal microtubule(GO:0005879)
0.0 4.4 GO:0016234 inclusion body(GO:0016234)
0.0 7.6 GO:0044306 neuron projection terminus(GO:0044306)
0.0 18.9 GO:0016607 nuclear speck(GO:0016607)
0.0 5.1 GO:0000922 spindle pole(GO:0000922)
0.0 0.9 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 5.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.5 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 1.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 4.5 GO:0000781 chromosome, telomeric region(GO:0000781)
0.0 0.3 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.3 GO:0045095 keratin filament(GO:0045095)
0.0 1.2 GO:0005903 brush border(GO:0005903)
0.0 2.5 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 1.6 GO:0005811 lipid particle(GO:0005811)
0.0 1.1 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 2.1 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.0 GO:0098803 respiratory chain complex(GO:0098803)
0.0 2.7 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 0.6 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.3 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 1.9 GO:0030141 secretory granule(GO:0030141)
0.0 0.2 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 52.4 GO:0005576 extracellular region(GO:0005576)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 18.4 GO:0071933 Arp2/3 complex binding(GO:0071933)
2.3 18.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
1.8 99.1 GO:0034987 immunoglobulin receptor binding(GO:0034987)
1.3 7.6 GO:0019238 cyclohydrolase activity(GO:0019238)
1.0 5.8 GO:0004167 dopachrome isomerase activity(GO:0004167)
1.0 8.6 GO:0070883 pre-miRNA binding(GO:0070883)
0.8 5.8 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.8 4.8 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.7 8.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.6 114.3 GO:0003823 antigen binding(GO:0003823)
0.6 6.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.6 5.9 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.6 1.8 GO:0033867 Fas-activated serine/threonine kinase activity(GO:0033867)
0.5 3.7 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.5 3.7 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.5 5.3 GO:0019237 centromeric DNA binding(GO:0019237)
0.5 3.4 GO:0061133 endopeptidase activator activity(GO:0061133)
0.5 3.6 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.4 19.3 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.4 1.1 GO:0016418 S-acetyltransferase activity(GO:0016418)
0.4 3.0 GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679)
0.4 5.5 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.3 1.3 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.3 1.9 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.3 5.9 GO:0043495 protein anchor(GO:0043495)
0.3 6.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.3 7.8 GO:0042288 MHC class I protein binding(GO:0042288)
0.3 1.6 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.2 3.4 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.2 0.6 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.2 0.6 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.2 0.6 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.2 2.7 GO:0016018 cyclosporin A binding(GO:0016018)
0.2 1.9 GO:0004312 fatty acid synthase activity(GO:0004312)
0.2 0.6 GO:0051538 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.2 0.9 GO:0015140 malate transmembrane transporter activity(GO:0015140)
0.2 0.7 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.2 33.2 GO:0005178 integrin binding(GO:0005178)
0.2 2.7 GO:0031996 thioesterase binding(GO:0031996)
0.2 2.5 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.2 1.6 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.1 2.4 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 1.6 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 18.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 2.2 GO:0005112 Notch binding(GO:0005112)
0.1 1.5 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 0.3 GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity(GO:0030272)
0.1 4.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 5.4 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1 0.8 GO:0004111 creatine kinase activity(GO:0004111)
0.1 0.9 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 0.9 GO:0008061 chitinase activity(GO:0004568) chitin binding(GO:0008061)
0.1 0.7 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.1 3.5 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 7.7 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 1.7 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 0.6 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 0.4 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 10.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 1.9 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.3 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 3.0 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.3 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 4.7 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.9 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 2.6 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.2 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.0 2.9 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.9 GO:0003785 actin monomer binding(GO:0003785)
0.0 5.3 GO:0051015 actin filament binding(GO:0051015)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 2.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 1.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.5 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 1.7 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.6 GO:0000217 DNA secondary structure binding(GO:0000217)
0.0 0.9 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 1.6 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.3 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.4 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 1.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 4.4 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 27.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.5 6.8 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 14.9 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.2 7.1 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.2 12.6 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.2 5.1 PID IGF1 PATHWAY IGF1 pathway
0.1 3.6 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 17.8 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 4.8 PID MYC PATHWAY C-MYC pathway
0.1 4.5 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 5.3 PID AURORA B PATHWAY Aurora B signaling
0.1 1.6 PID IL27 PATHWAY IL27-mediated signaling events
0.1 2.9 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.1 2.7 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 3.7 PID ARF6 PATHWAY Arf6 signaling events
0.1 2.3 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 2.5 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 4.0 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.6 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 1.1 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.2 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 1.8 NABA COLLAGENS Genes encoding collagen proteins
0.0 6.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 2.2 PID NOTCH PATHWAY Notch signaling pathway
0.0 1.5 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.7 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 2.6 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.1 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.8 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.9 PID BCR 5PATHWAY BCR signaling pathway
0.0 1.5 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.4 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 2.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.5 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.5 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.4 3.7 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.3 5.1 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.3 29.1 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.3 21.1 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.3 6.8 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 5.0 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.2 5.3 REACTOME KINESINS Genes involved in Kinesins
0.2 3.7 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.2 8.0 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 14.9 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.2 6.0 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.2 8.9 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 5.8 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 1.5 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 4.8 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.1 3.8 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 26.8 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 1.3 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.1 3.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.3 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 1.1 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 5.5 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 2.3 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 6.5 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.1 1.6 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 1.1 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.9 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 1.6 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.7 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.8 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.4 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.5 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 1.8 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.7 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.4 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.6 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 3.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.6 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.0 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 2.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.3 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.2 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 1.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.7 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds