ISMARA results: TP53

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for TP53

Z-value: 0.75

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Transcription factors associated with TP53

Gene Symbol	Gene ID	Gene Info
TP53 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000141510.11	tumor protein p53

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TP53	hg19_v2_chr17_-_7590745_7590856	0.50	2.5e-15	Click!

Activity profile of TP53 motif

Sorted Z-values of TP53 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_-_30712313 Show fit	32.55	ENST00000376377.2 ENST00000259874.5	IER3 Ensembl NCBI GeneCards UniProt NextProt Show fit	immediate early response 3
chr7_+_116165754 Show fit	20.19	ENST00000405348.1	CAV1 Ensembl NCBI GeneCards UniProt NextProt Show fit	caveolin 1, caveolae protein, 22kDa
chr1_+_156052354 Show fit	19.39	ENST00000368301.2	LMNA Ensembl NCBI GeneCards UniProt NextProt Show fit	lamin A/C
chr15_-_64455404 Show fit	15.82	ENST00000300026.3	PPIB Ensembl NCBI GeneCards UniProt NextProt Show fit	peptidylprolyl isomerase B (cyclophilin B)
chr1_+_203830703 Show fit	15.61	ENST00000414487.2	SNRPE Ensembl NCBI GeneCards UniProt NextProt Show fit	small nuclear ribonucleoprotein polypeptide E
chr6_-_138428613 Show fit	15.13	ENST00000421351.3	PERP Ensembl NCBI GeneCards UniProt NextProt Show fit	PERP, TP53 apoptosis effector
chr4_-_10118348 Show fit	13.66	ENST00000502702.1	WDR1 Ensembl NCBI GeneCards UniProt NextProt Show fit	WD repeat domain 1
chr20_+_33759854 Show fit	13.35	ENST00000216968.4	PROCR Ensembl NCBI GeneCards UniProt NextProt Show fit	protein C receptor, endothelial
chr20_-_5100591 Show fit	13.16	ENST00000379143.5	PCNA Ensembl NCBI GeneCards UniProt NextProt Show fit	proliferating cell nuclear antigen
chr17_+_76210267 Show fit	13.14	ENST00000301633.4 ENST00000350051.3 ENST00000374948.2 ENST00000590449.1	BIRC5 Ensembl NCBI GeneCards UniProt NextProt Show fit	baculoviral IAP repeat containing 5

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TP53

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
10.3	41.4	GO:0016334	morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
0.2	34.2	GO:0014066	regulation of phosphatidylinositol 3-kinase signaling(GO:0014066)
2.2	25.9	GO:0022417	protein maturation by protein folding(GO:0022417)
0.9	25.7	GO:0043968	histone H2A acetylation(GO:0043968)
3.4	20.5	GO:1902766	skeletal muscle satellite cell migration(GO:1902766)
6.7	20.2	GO:1903609	negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
2.0	19.9	GO:0042373	vitamin K metabolic process(GO:0042373)
1.1	19.8	GO:1990001	inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.3	19.8	GO:0018279	protein N-linked glycosylation via asparagine(GO:0018279)
3.9	19.4	GO:0035105	sterol regulatory element binding protein import into nucleus(GO:0035105)

Showing 1 to 10 of 124 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
8.3	41.4	GO:0042643	actomyosin, actin portion(GO:0042643)
0.1	40.3	GO:0005925	focal adhesion(GO:0005925)
1.5	35.7	GO:0016580	Sin3 complex(GO:0016580)
3.6	32.3	GO:0005638	lamin filament(GO:0005638)
0.4	26.4	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.0	26.1	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
5.2	25.9	GO:1990425	ryanodine receptor complex(GO:1990425)
0.6	20.5	GO:0032420	stereocilium(GO:0032420)
1.4	20.2	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
2.5	19.8	GO:0032133	chromosome passenger complex(GO:0032133)

Showing 1 to 10 of 74 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	61.5	GO:0051015	actin filament binding(GO:0051015)
0.2	26.5	GO:0047485	protein N-terminus binding(GO:0047485)
1.9	25.9	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	24.4	GO:0005509	calcium ion binding(GO:0005509)
6.7	20.2	GO:0070320	inward rectifier potassium channel inhibitor activity(GO:0070320)
5.0	19.9	GO:0016900	oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057)
0.4	19.8	GO:0008536	Ran GTPase binding(GO:0008536)
2.3	16.1	GO:0004704	NF-kappaB-inducing kinase activity(GO:0004704)
0.3	15.8	GO:0070063	RNA polymerase binding(GO:0070063)
1.6	15.6	GO:1990446	U1 snRNP binding(GO:1990446)

Showing 1 to 10 of 101 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	72.5	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.3	65.0	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
1.4	25.9	PID ALK2 PATHWAY	ALK2 signaling events
0.6	20.5	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.7	20.2	PID ALK1 PATHWAY	ALK1 signaling events
0.3	19.8	PID AURORA B PATHWAY	Aurora B signaling
0.5	16.1	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.2	12.8	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.1	11.8	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.5	11.2	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions

Showing 1 to 10 of 25 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	48.9	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.4	28.3	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
1.1	25.9	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.8	24.4	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.9	23.3	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.2	21.8	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.7	21.2	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.5	20.8	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
1.3	19.9	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.2	19.4	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins

Showing 1 to 10 of 43 entries

Results for TP53

Z-value: 0.75

Motif logo

Transcription factors associated with TP53

Activity-expression correlation:

Activity profile of TP53 motif

Sorted Z-values of TP53 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TP53

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: