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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for TP63
Z-value: 0.63
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Transcription factors associated with TP63
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TP63 | hg19_v2_chr3_+_189507523_189507590 | -0.44 | 1.5e-11 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TP63
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 44.7 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.9 | 43.2 | GO:0006363 | transcription elongation from RNA polymerase I promoter(GO:0006362) termination of RNA polymerase I transcription(GO:0006363) |
| 0.7 | 34.5 | GO:0032731 | positive regulation of interleukin-1 beta production(GO:0032731) |
| 0.6 | 31.9 | GO:0018279 | peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279) |
| 1.9 | 30.3 | GO:0008635 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635) |
| 1.0 | 29.5 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.2 | 27.2 | GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling(GO:0014066) |
| 7.9 | 23.8 | GO:0001732 | formation of cytoplasmic translation initiation complex(GO:0001732) |
| 3.9 | 23.4 | GO:0016479 | negative regulation of transcription from RNA polymerase I promoter(GO:0016479) |
| 5.4 | 21.7 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 64.3 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 2.4 | 43.2 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 3.8 | 34.2 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 2.1 | 30.0 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.1 | 27.5 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.3 | 27.4 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 7.8 | 23.4 | GO:0031523 | Myb complex(GO:0031523) |
| 0.2 | 23.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 22.7 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.2 | 22.6 | GO:0005882 | intermediate filament(GO:0005882) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 44.7 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.3 | 43.4 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 2.4 | 43.2 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.1 | 31.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.1 | 23.8 | GO:0000339 | RNA cap binding(GO:0000339) |
| 5.8 | 23.4 | GO:0034988 | Fc-gamma receptor I complex binding(GO:0034988) |
| 0.3 | 21.3 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.7 | 20.7 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.6 | 19.7 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 2.7 | 18.9 | GO:0004673 | protein histidine kinase activity(GO:0004673) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 60.3 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.5 | 51.2 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.4 | 28.2 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.3 | 25.4 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.5 | 22.0 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.2 | 21.7 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.7 | 18.9 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.4 | 18.0 | PID MYC PATHWAY | C-MYC pathway |
| 0.3 | 13.9 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.3 | 13.8 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 59.4 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 1.9 | 43.2 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.7 | 37.6 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.2 | 29.7 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.4 | 26.0 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.2 | 23.3 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 20.5 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.6 | 18.9 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.5 | 18.1 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.2 | 17.4 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |