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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for TP73
Z-value: 0.98
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Transcription factors associated with TP73
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TP73 | hg19_v2_chr1_+_3569129_3569150 | 0.42 | 1.5e-10 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TP73
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.3 | 50.1 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 0.0 | 16.1 | GO:0098655 | cation transmembrane transport(GO:0098655) |
| 0.8 | 12.9 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
| 2.0 | 11.8 | GO:0034441 | plasma lipoprotein particle oxidation(GO:0034441) |
| 0.9 | 11.2 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.6 | 10.4 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 0.5 | 10.4 | GO:0006853 | carnitine shuttle(GO:0006853) |
| 0.2 | 10.3 | GO:0042073 | intraciliary transport(GO:0042073) |
| 0.0 | 8.6 | GO:0002576 | platelet degranulation(GO:0002576) |
| 0.6 | 7.4 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.3 | 50.1 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.3 | 13.0 | GO:0005605 | basal lamina(GO:0005605) |
| 0.4 | 11.8 | GO:0034362 | low-density lipoprotein particle(GO:0034362) |
| 0.8 | 11.2 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.1 | 10.3 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.0 | 10.0 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.4 | 9.2 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.1 | 8.6 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 8.1 | GO:0000779 | condensed chromosome, centromeric region(GO:0000779) |
| 0.0 | 7.3 | GO:0016607 | nuclear speck(GO:0016607) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 50.1 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 14.0 | GO:0005261 | cation channel activity(GO:0005261) |
| 2.2 | 12.9 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.0 | 12.7 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 1.5 | 11.8 | GO:0003847 | 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) |
| 0.2 | 11.2 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 3.5 | 10.4 | GO:0015199 | amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226) |
| 0.1 | 10.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.4 | 8.1 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.5 | 6.7 | GO:0038132 | neuregulin binding(GO:0038132) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 50.1 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.4 | 12.9 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 11.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.3 | 11.8 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.2 | 11.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 9.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 8.1 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.1 | 8.0 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.1 | 7.2 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 7.1 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 54.0 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.6 | 17.4 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.7 | 11.8 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.3 | 10.4 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.2 | 10.0 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 9.2 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.1 | 8.1 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 6.3 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 6.1 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.2 | 4.5 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |