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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for UAAGACG

Z-value: 0.04

Motif logo

miRNA associated with seed UAAGACG

NamemiRBASE accession
MIMAT0000241
MIMAT0004960

Activity profile of UAAGACG motif

Sorted Z-values of UAAGACG motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_43328004 2.88 ENST00000454177.1
ENST00000429705.2
ENST00000296088.7
ENST00000437827.1
SNF related kinase
chr3_-_18466787 2.84 ENST00000338745.6
ENST00000450898.1
SATB homeobox 1
chr6_-_99797522 2.76 ENST00000389677.5
failed axon connections homolog (Drosophila)
chr8_+_56014949 2.52 ENST00000327381.6
XK, Kell blood group complex subunit-related family, member 4
chr10_+_11206925 2.49 ENST00000354440.2
ENST00000315874.4
ENST00000427450.1
CUGBP, Elav-like family member 2
chr2_+_120517174 2.24 ENST00000263708.2
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr8_+_38614807 1.78 ENST00000330691.6
ENST00000348567.4
transforming, acidic coiled-coil containing protein 1
chr12_-_92539614 1.69 ENST00000256015.3
B-cell translocation gene 1, anti-proliferative
chr1_-_108507631 1.68 ENST00000527011.1
ENST00000370056.4
vav 3 guanine nucleotide exchange factor
chr13_-_107220455 1.65 ENST00000400198.3
arginine and glutamate rich 1
chr10_+_112631547 1.63 ENST00000280154.7
ENST00000393104.2
programmed cell death 4 (neoplastic transformation inhibitor)
chr14_-_99737565 1.41 ENST00000357195.3
B-cell CLL/lymphoma 11B (zinc finger protein)
chr6_+_21593972 1.39 ENST00000244745.1
ENST00000543472.1
SRY (sex determining region Y)-box 4
chr7_-_139876812 1.36 ENST00000397560.2
lysine (K)-specific demethylase 7A
chr3_-_72496035 1.25 ENST00000477973.2
RING1 and YY1 binding protein
chr5_+_122110691 1.20 ENST00000379516.2
ENST00000505934.1
ENST00000514949.1
sorting nexin 2
chr10_-_27149792 1.17 ENST00000376140.3
ENST00000376170.4
abl-interactor 1
chr4_-_100871506 1.14 ENST00000296417.5
H2A histone family, member Z
chr15_+_57210818 1.12 ENST00000438423.2
ENST00000267811.5
ENST00000452095.2
ENST00000559609.1
ENST00000333725.5
transcription factor 12
chr13_+_50571155 1.08 ENST00000420995.2
ENST00000378182.3
ENST00000356017.4
ENST00000457662.2
tripartite motif containing 13
chrY_+_15016725 1.03 ENST00000336079.3
DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
chr7_-_26240357 1.00 ENST00000354667.4
ENST00000356674.7
heterogeneous nuclear ribonucleoprotein A2/B1
chr3_+_186501336 0.99 ENST00000323963.5
ENST00000440191.2
ENST00000356531.5
eukaryotic translation initiation factor 4A2
chr15_+_52311398 0.97 ENST00000261845.5
mitogen-activated protein kinase 6
chrX_+_41192595 0.91 ENST00000399959.2
DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
chr13_-_50367057 0.90 ENST00000261667.3
karyopherin alpha 3 (importin alpha 4)
chr3_-_15374033 0.87 ENST00000253688.5
ENST00000383791.3
SH3-domain binding protein 5 (BTK-associated)
chr20_+_48552908 0.78 ENST00000244061.2
ring finger protein 114
chr9_-_127952032 0.70 ENST00000456642.1
ENST00000373546.3
ENST00000373547.4
protein phosphatase 6, catalytic subunit
chr14_-_21737610 0.67 ENST00000320084.7
ENST00000449098.1
ENST00000336053.6
heterogeneous nuclear ribonucleoprotein C (C1/C2)
chr2_-_68290106 0.63 ENST00000407324.1
ENST00000355848.3
ENST00000409302.1
ENST00000410067.3
C1D nuclear receptor corepressor
chr10_+_63661053 0.59 ENST00000279873.7
AT rich interactive domain 5B (MRF1-like)
chr12_+_72148614 0.58 ENST00000261263.3
RAB21, member RAS oncogene family
chr17_+_66508537 0.57 ENST00000392711.1
ENST00000585427.1
ENST00000589228.1
ENST00000536854.2
ENST00000588702.1
ENST00000589309.1
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr8_+_48920960 0.55 ENST00000523111.2
ENST00000523432.1
ENST00000521346.1
ENST00000517630.1
ubiquitin-conjugating enzyme E2 variant 2
chr12_+_68042495 0.52 ENST00000344096.3
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr9_+_82186872 0.51 ENST00000376544.3
ENST00000376520.4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr17_-_73775839 0.50 ENST00000592643.1
ENST00000591890.1
ENST00000587171.1
ENST00000254810.4
ENST00000589599.1
H3 histone, family 3B (H3.3B)
chr1_+_43148059 0.39 ENST00000321358.7
ENST00000332220.6
Y box binding protein 1
chr14_-_105487381 0.38 ENST00000392590.3
ENST00000336219.3
cell division cycle associated 4
chr12_+_50135588 0.37 ENST00000423828.1
ENST00000550445.1
transmembrane BAX inhibitor motif containing 6
chr1_-_39339777 0.36 ENST00000397572.2
MYC binding protein
chr20_+_51588873 0.35 ENST00000371497.5
teashirt zinc finger homeobox 2
chr1_-_55680762 0.34 ENST00000407756.1
ENST00000294383.6
ubiquitin specific peptidase 24
chr5_-_76788317 0.33 ENST00000296679.4
WD repeat domain 41
chr2_+_42396472 0.32 ENST00000318522.5
ENST00000402711.2
echinoderm microtubule associated protein like 4
chr21_-_16437255 0.31 ENST00000400199.1
ENST00000400202.1
nuclear receptor interacting protein 1
chr2_-_208030647 0.30 ENST00000309446.6
Kruppel-like factor 7 (ubiquitous)
chr1_-_154842741 0.29 ENST00000271915.4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr6_-_13711773 0.26 ENST00000011619.3
RAN binding protein 9
chr6_+_163835669 0.25 ENST00000453779.2
ENST00000275262.7
ENST00000392127.2
ENST00000361752.3
QKI, KH domain containing, RNA binding
chr1_-_21113105 0.24 ENST00000375000.1
ENST00000419490.1
ENST00000414993.1
ENST00000443615.1
ENST00000312239.5
heterochromatin protein 1, binding protein 3
chr2_-_174830430 0.24 ENST00000310015.6
ENST00000455789.2
Sp3 transcription factor
chr2_-_131850951 0.23 ENST00000409185.1
ENST00000389915.3
family with sequence similarity 168, member B
chr16_-_46655538 0.23 ENST00000303383.3
SHC SH2-domain binding protein 1
chr7_-_105029329 0.22 ENST00000393651.3
ENST00000460391.1
SRSF protein kinase 2
chr1_+_36396677 0.22 ENST00000373191.4
ENST00000397828.2
argonaute RISC catalytic component 3
chr10_-_32345305 0.21 ENST00000302418.4
kinesin family member 5B
chr2_+_176987088 0.21 ENST00000249499.6
homeobox D9
chr4_-_66536057 0.20 ENST00000273854.3
EPH receptor A5
chr7_-_30029367 0.17 ENST00000242059.5
secernin 1
chr3_-_15563229 0.14 ENST00000383786.5
ENST00000383787.2
ENST00000383785.2
ENST00000383788.5
ENST00000603808.1
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr1_-_39347255 0.14 ENST00000454994.2
ENST00000357771.3
gap junction protein, alpha 9, 59kDa
chr17_+_58677539 0.13 ENST00000305921.3
protein phosphatase, Mg2+/Mn2+ dependent, 1D
chr2_-_240322643 0.09 ENST00000345617.3
histone deacetylase 4
chr17_-_48785216 0.08 ENST00000285243.6
ankyrin repeat domain 40
chr17_-_5389477 0.08 ENST00000572834.1
ENST00000570848.1
ENST00000571971.1
ENST00000158771.4
derlin 2
chr15_-_56535464 0.05 ENST00000559447.2
ENST00000422057.1
ENST00000317318.6
ENST00000423270.1
regulatory factor X, 7
chr3_+_89156674 0.03 ENST00000336596.2
EPH receptor A3
chr7_+_155089486 0.01 ENST00000340368.4
ENST00000344756.4
ENST00000425172.1
ENST00000342407.5
insulin induced gene 1

Network of associatons between targets according to the STRING database.

First level regulatory network of UAAGACG

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
0.4 1.4 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.3 1.4 GO:0035910 N-terminal peptidyl-lysine acetylation(GO:0018076) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.2 1.0 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.2 0.9 GO:0042256 mature ribosome assembly(GO:0042256)
0.2 2.8 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 1.7 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.1 0.5 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.1 1.2 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 1.2 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.1 0.4 GO:0051025 negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.1 2.3 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 1.1 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.1 0.6 GO:2000643 positive regulation of early endosome to late endosome transport(GO:2000643)
0.1 1.2 GO:0035855 megakaryocyte development(GO:0035855)
0.1 0.4 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 2.2 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.2 GO:0035063 nuclear speck organization(GO:0035063)
0.0 0.2 GO:0035617 stress granule disassembly(GO:0035617)
0.0 0.2 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 1.7 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.6 GO:2000480 negative regulation of meiotic nuclear division(GO:0045835) negative regulation of activated T cell proliferation(GO:0046007) negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.7 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.0 0.9 GO:0019054 modulation by virus of host process(GO:0019054)
0.0 0.9 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 0.1 GO:0006581 acetylcholine catabolic process in synaptic cleft(GO:0001507) acetylcholine catabolic process(GO:0006581)
0.0 0.3 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.0 1.5 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.0 0.5 GO:0000729 DNA double-strand break processing(GO:0000729)
0.0 0.6 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.0 0.6 GO:0016577 histone demethylation(GO:0016577)
0.0 1.0 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 0.2 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 1.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.1 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.1 GO:0070862 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 0.1 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.2 GO:0070828 heterochromatin organization(GO:0070828)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0030905 retromer, tubulation complex(GO:0030905)
0.2 1.1 GO:0001740 Barr body(GO:0001740)
0.2 0.5 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.1 1.2 GO:0031209 SCAR complex(GO:0031209)
0.1 0.6 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
0.1 2.8 GO:0005720 nuclear heterochromatin(GO:0005720)
0.1 1.1 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 0.6 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 0.3 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.4 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 1.0 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 1.0 GO:0032156 septin cytoskeleton(GO:0032156)
0.0 0.6 GO:0031588 cAMP-dependent protein kinase complex(GO:0005952) nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.2 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 1.2 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.7 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.2 GO:0035253 ciliary rootlet(GO:0035253)
0.0 1.0 GO:0015030 Cajal body(GO:0015030)
0.0 0.1 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 0.1 GO:0043083 synaptic cleft(GO:0043083)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:1990460 leptin receptor binding(GO:1990460)
0.2 2.2 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 1.7 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 1.1 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 0.9 GO:0033592 RNA strand annealing activity(GO:0033592)
0.1 1.7 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.4 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.1 0.3 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 0.2 GO:0099609 microtubule lateral binding(GO:0099609)
0.1 1.1 GO:0035497 cAMP response element binding(GO:0035497)
0.1 2.3 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 1.0 GO:0004707 MAP kinase activity(GO:0004707)
0.0 1.2 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 2.0 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.6 GO:0008603 cAMP-dependent protein kinase inhibitor activity(GO:0004862) cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 1.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.9 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 1.4 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.8 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.1 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.0 0.6 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.6 GO:0032452 histone demethylase activity(GO:0032452)
0.0 3.6 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.2 GO:0035198 miRNA binding(GO:0035198)
0.0 0.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.2 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 1.8 PID AURORA A PATHWAY Aurora A signaling
0.0 1.7 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 2.8 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.2 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 1.6 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 1.1 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.6 PID P53 REGULATION PATHWAY p53 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.7 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 1.6 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 2.3 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.1 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.6 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 2.1 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.1 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis