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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for UAAGACU

Z-value: 0.37

Motif logo

miRNA associated with seed UAAGACU

NamemiRBASE accession
MIMAT0002870

Activity profile of UAAGACU motif

Sorted Z-values of UAAGACU motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_139876812 2.68 ENST00000397560.2
lysine (K)-specific demethylase 7A
chr3_-_18466787 2.51 ENST00000338745.6
ENST00000450898.1
SATB homeobox 1
chr3_+_43328004 1.98 ENST00000454177.1
ENST00000429705.2
ENST00000296088.7
ENST00000437827.1
SNF related kinase
chr8_+_56014949 1.75 ENST00000327381.6
XK, Kell blood group complex subunit-related family, member 4
chr6_-_99797522 1.62 ENST00000389677.5
failed axon connections homolog (Drosophila)
chr10_+_112631547 1.57 ENST00000280154.7
ENST00000393104.2
programmed cell death 4 (neoplastic transformation inhibitor)
chrX_+_16737718 1.55 ENST00000380155.3
synapse associated protein 1
chrY_+_15016725 1.51 ENST00000336079.3
DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
chr14_-_99737565 1.41 ENST00000357195.3
B-cell CLL/lymphoma 11B (zinc finger protein)
chr8_+_38614807 1.41 ENST00000330691.6
ENST00000348567.4
transforming, acidic coiled-coil containing protein 1
chr6_+_72596604 1.32 ENST00000348717.5
ENST00000517960.1
ENST00000518273.1
ENST00000522291.1
ENST00000521978.1
ENST00000520567.1
ENST00000264839.7
regulating synaptic membrane exocytosis 1
chr13_+_50571155 1.30 ENST00000420995.2
ENST00000378182.3
ENST00000356017.4
ENST00000457662.2
tripartite motif containing 13
chr5_+_55033845 1.24 ENST00000353507.5
ENST00000514278.2
ENST00000505374.1
ENST00000506511.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr5_-_131132614 1.11 ENST00000307968.7
ENST00000307954.8
folliculin interacting protein 1
chr1_-_108507631 1.03 ENST00000527011.1
ENST00000370056.4
vav 3 guanine nucleotide exchange factor
chr5_-_79287060 0.94 ENST00000512560.1
ENST00000509852.1
ENST00000512528.1
metaxin 3
chr2_+_120517174 0.93 ENST00000263708.2
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr1_-_16678914 0.88 ENST00000375592.3
F-box protein 42
chr7_+_138916231 0.85 ENST00000473989.3
ENST00000288561.8
ubinuclein 2
chr14_-_50698276 0.82 ENST00000216373.5
son of sevenless homolog 2 (Drosophila)
chr7_-_105029329 0.79 ENST00000393651.3
ENST00000460391.1
SRSF protein kinase 2
chr9_+_82186872 0.71 ENST00000376544.3
ENST00000376520.4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr7_+_65338230 0.67 ENST00000360768.3
vitamin K epoxide reductase complex, subunit 1-like 1
chr13_-_107220455 0.63 ENST00000400198.3
arginine and glutamate rich 1
chr3_+_186501336 0.62 ENST00000323963.5
ENST00000440191.2
ENST00000356531.5
eukaryotic translation initiation factor 4A2
chr8_+_42752053 0.60 ENST00000307602.4
hook microtubule-tethering protein 3
chr2_-_86564776 0.59 ENST00000165698.5
ENST00000541910.1
ENST00000535845.1
receptor accessory protein 1
chr15_-_64648273 0.55 ENST00000607537.1
ENST00000303052.7
ENST00000303032.6
casein kinase 1, gamma 1
chr3_-_15374033 0.54 ENST00000253688.5
ENST00000383791.3
SH3-domain binding protein 5 (BTK-associated)
chr8_+_11561660 0.53 ENST00000526716.1
ENST00000335135.4
ENST00000528027.1
GATA binding protein 4
chr6_+_21593972 0.52 ENST00000244745.1
ENST00000543472.1
SRY (sex determining region Y)-box 4
chr1_-_154842741 0.51 ENST00000271915.4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr9_-_23821273 0.51 ENST00000380110.4
ELAV like neuron-specific RNA binding protein 2
chr10_+_63661053 0.51 ENST00000279873.7
AT rich interactive domain 5B (MRF1-like)
chr6_-_13711773 0.50 ENST00000011619.3
RAN binding protein 9
chr17_+_58677539 0.50 ENST00000305921.3
protein phosphatase, Mg2+/Mn2+ dependent, 1D
chr14_+_105781048 0.46 ENST00000458164.2
ENST00000447393.1
phosphofurin acidic cluster sorting protein 2
chr11_-_128392085 0.40 ENST00000526145.2
ENST00000531611.1
ENST00000319397.6
ENST00000345075.4
ENST00000535549.1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr12_-_42538657 0.40 ENST00000398675.3
glucoside xylosyltransferase 1
chr8_+_58907104 0.39 ENST00000361488.3
family with sequence similarity 110, member B
chr17_+_29718642 0.38 ENST00000325874.8
RAB11 family interacting protein 4 (class II)
chr2_-_208030647 0.38 ENST00000309446.6
Kruppel-like factor 7 (ubiquitous)
chr3_-_72496035 0.34 ENST00000477973.2
RING1 and YY1 binding protein
chr5_+_112312416 0.34 ENST00000389063.2
decapping mRNA 2
chr19_-_7293942 0.33 ENST00000341500.5
ENST00000302850.5
insulin receptor
chr6_+_37225540 0.32 ENST00000373491.3
TBC1 domain family, member 22B
chr20_+_51588873 0.32 ENST00000371497.5
teashirt zinc finger homeobox 2
chr9_+_101867359 0.30 ENST00000374994.4
transforming growth factor, beta receptor 1
chr12_+_68042495 0.29 ENST00000344096.3
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr17_-_62050278 0.28 ENST00000578147.1
ENST00000435607.1
sodium channel, voltage-gated, type IV, alpha subunit
chr17_-_73775839 0.24 ENST00000592643.1
ENST00000591890.1
ENST00000587171.1
ENST00000254810.4
ENST00000589599.1
H3 histone, family 3B (H3.3B)
chr15_+_101142722 0.24 ENST00000332783.7
ENST00000558747.1
ENST00000343276.4
ankyrin repeat and SOCS box containing 7
chr6_+_133562472 0.23 ENST00000430974.2
ENST00000367895.5
ENST00000355167.3
ENST00000355286.6
eyes absent homolog 4 (Drosophila)
chr11_-_86666427 0.23 ENST00000531380.1
frizzled family receptor 4
chr14_-_61116168 0.22 ENST00000247182.6
SIX homeobox 1
chr15_-_45815005 0.22 ENST00000261867.4
solute carrier family 30 (zinc transporter), member 4
chr4_+_139936905 0.21 ENST00000280614.2
CCR4 carbon catabolite repression 4-like (S. cerevisiae)
chr2_+_228029281 0.21 ENST00000396578.3
collagen, type IV, alpha 3 (Goodpasture antigen)
chr12_-_93323013 0.20 ENST00000322349.8
early endosome antigen 1
chr2_+_176987088 0.18 ENST00000249499.6
homeobox D9
chr1_+_97187318 0.17 ENST00000609116.1
ENST00000370198.1
ENST00000370197.1
ENST00000426398.2
ENST00000394184.3
polypyrimidine tract binding protein 2
chr17_-_45266542 0.17 ENST00000531206.1
ENST00000527547.1
ENST00000446365.2
ENST00000575483.1
ENST00000066544.3
cell division cycle 27
chr8_-_67579418 0.16 ENST00000310421.4
valosin containing protein (p97)/p47 complex interacting protein 1
chr16_+_54964740 0.16 ENST00000394636.4
iroquois homeobox 5
chr8_-_89339705 0.15 ENST00000286614.6
matrix metallopeptidase 16 (membrane-inserted)
chr2_+_176981307 0.15 ENST00000249501.4
homeobox D10
chr2_+_42396472 0.14 ENST00000318522.5
ENST00000402711.2
echinoderm microtubule associated protein like 4
chr9_-_19786926 0.13 ENST00000341998.2
ENST00000286344.3
solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
chr1_-_21113105 0.13 ENST00000375000.1
ENST00000419490.1
ENST00000414993.1
ENST00000443615.1
ENST00000312239.5
heterochromatin protein 1, binding protein 3
chr1_+_36396677 0.13 ENST00000373191.4
ENST00000397828.2
argonaute RISC catalytic component 3
chr3_+_29322803 0.12 ENST00000396583.3
ENST00000383767.2
RNA binding motif, single stranded interacting protein 3
chr15_-_56535464 0.12 ENST00000559447.2
ENST00000422057.1
ENST00000317318.6
ENST00000423270.1
regulatory factor X, 7
chr17_-_5389477 0.11 ENST00000572834.1
ENST00000570848.1
ENST00000571971.1
ENST00000158771.4
derlin 2
chr22_+_21771656 0.11 ENST00000407464.2
hypermethylated in cancer 2
chr7_-_44924939 0.11 ENST00000395699.2
purine-rich element binding protein B
chr2_-_71454185 0.11 ENST00000244221.8
poly(A) binding protein interacting protein 2B
chr5_+_122110691 0.10 ENST00000379516.2
ENST00000505934.1
ENST00000514949.1
sorting nexin 2
chr3_-_15563229 0.10 ENST00000383786.5
ENST00000383787.2
ENST00000383785.2
ENST00000383788.5
ENST00000603808.1
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr17_+_38219063 0.10 ENST00000584985.1
ENST00000264637.4
ENST00000450525.2
thyroid hormone receptor, alpha
chr22_-_46933067 0.10 ENST00000262738.3
ENST00000395964.1
cadherin, EGF LAG seven-pass G-type receptor 1
chr5_-_76788317 0.09 ENST00000296679.4
WD repeat domain 41
chr10_-_27149792 0.09 ENST00000376140.3
ENST00000376170.4
abl-interactor 1
chr1_-_159684371 0.06 ENST00000255030.5
ENST00000437342.1
ENST00000368112.1
ENST00000368111.1
ENST00000368110.1
ENST00000343919.2
C-reactive protein, pentraxin-related
chr13_+_102104980 0.05 ENST00000545560.2
integrin, beta-like 1 (with EGF-like repeat domains)
chr6_+_163835669 0.04 ENST00000453779.2
ENST00000275262.7
ENST00000392127.2
ENST00000361752.3
QKI, KH domain containing, RNA binding
chrX_+_41192595 0.03 ENST00000399959.2
DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
chr22_+_30279144 0.03 ENST00000401950.2
ENST00000333027.3
ENST00000445401.1
ENST00000323630.5
ENST00000351488.3
myotubularin related protein 3
chr3_+_89156674 0.02 ENST00000336596.2
EPH receptor A3
chr17_-_60142609 0.02 ENST00000397786.2
mediator complex subunit 13
chr1_+_50574585 0.00 ENST00000371824.1
ENST00000371823.4
ELAV like neuron-specific RNA binding protein 4

Network of associatons between targets according to the STRING database.

First level regulatory network of UAAGACU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
0.4 1.4 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.3 1.1 GO:0002904 positive regulation of B cell apoptotic process(GO:0002904)
0.2 1.0 GO:0003289 atrial septum primum morphogenesis(GO:0003289)
0.2 0.8 GO:0035063 nuclear speck organization(GO:0035063)
0.2 2.5 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.2 1.2 GO:0034587 piRNA metabolic process(GO:0034587)
0.2 0.6 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.1 0.3 GO:1990535 transformation of host cell by virus(GO:0019087) neuron projection maintenance(GO:1990535)
0.1 0.4 GO:0030578 PML body organization(GO:0030578)
0.1 0.3 GO:1905075 proepicardium development(GO:0003342) septum transversum development(GO:0003343) occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075)
0.1 0.2 GO:2000729 myotome development(GO:0061055) positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.1 1.3 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.1 1.3 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.1 0.7 GO:0042373 vitamin K metabolic process(GO:0042373)
0.1 0.3 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.1 0.2 GO:0061304 extracellular matrix-cell signaling(GO:0035426) progesterone secretion(GO:0042701) retinal blood vessel morphogenesis(GO:0061304)
0.0 0.3 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 2.3 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.2 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.2 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.6 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.0 0.4 GO:0070314 G1 to G0 transition(GO:0070314)
0.0 0.1 GO:0045925 female courtship behavior(GO:0008050) positive regulation of female receptivity(GO:0045925)
0.0 0.1 GO:0060448 dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
0.0 0.5 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.5 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 0.1 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 0.1 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.0 0.2 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.9 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.5 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 0.3 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.0 0.2 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.2 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0 0.1 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 0.5 GO:0016577 histone demethylation(GO:0016577)
0.0 0.5 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.7 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 0.8 GO:0051057 positive regulation of small GTPase mediated signal transduction(GO:0051057)
0.0 1.4 GO:0021987 cerebral cortex development(GO:0021987)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0071546 pi-body(GO:0071546)
0.2 0.6 GO:0070695 FHF complex(GO:0070695)
0.1 1.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 0.3 GO:0005899 insulin receptor complex(GO:0005899)
0.1 2.5 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.2 GO:0044308 axonal spine(GO:0044308)
0.0 0.3 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.6 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.6 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.5 GO:0031332 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 1.3 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.2 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.1 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.1 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 0.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.2 0.7 GO:0016900 oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057)
0.1 1.3 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 0.5 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 0.4 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.1 0.9 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.5 GO:0051525 NFAT protein binding(GO:0051525)
0.0 3.4 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 1.0 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.3 GO:0043559 insulin binding(GO:0043559)
0.0 0.3 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.0 1.1 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.6 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.2 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.4 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.1 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.5 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.1 GO:0033265 choline binding(GO:0033265)
0.0 0.2 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.5 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.5 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.1 GO:0070324 thyroid hormone binding(GO:0070324)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.8 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 1.4 PID AURORA A PATHWAY Aurora A signaling
0.0 2.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.5 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 1.6 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.3 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.9 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.8 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.5 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 2.5 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.3 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 1.0 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.6 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.3 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.4 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.7 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription