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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for UAAGGCA
Z-value: 0.56
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miRNA associated with seed UAAGGCA
Network of associatons between targets according to the STRING database.
First level regulatory network of UAAGGCA
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 22.5 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.4 | 21.8 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 1.2 | 17.9 | GO:0019511 | peptidyl-proline hydroxylation(GO:0019511) |
| 2.7 | 16.4 | GO:0019367 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 2.7 | 15.9 | GO:0036444 | calcium ion transmembrane import into mitochondrion(GO:0036444) |
| 0.1 | 15.9 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.8 | 15.5 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.6 | 14.2 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
| 0.5 | 14.0 | GO:0051923 | sulfation(GO:0051923) |
| 1.9 | 13.5 | GO:1903593 | regulation of histamine secretion by mast cell(GO:1903593) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 67.5 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.3 | 27.7 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.4 | 26.9 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.3 | 25.7 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.1 | 20.0 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 1.1 | 19.1 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.0 | 18.5 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.6 | 17.8 | GO:0005685 | U1 snRNP(GO:0005685) |
| 0.3 | 17.0 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 1.6 | 15.8 | GO:0042584 | chromaffin granule membrane(GO:0042584) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 49.3 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 34.9 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 29.9 | GO:0005525 | GTP binding(GO:0005525) |
| 0.3 | 21.6 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.5 | 20.9 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.1 | 18.5 | GO:0005125 | cytokine activity(GO:0005125) |
| 3.6 | 17.9 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798) |
| 0.4 | 17.0 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.4 | 16.8 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.7 | 16.6 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 23.6 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.1 | 23.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.5 | 20.5 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.2 | 19.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.3 | 17.7 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.4 | 15.5 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.2 | 15.4 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 14.5 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.3 | 12.8 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.5 | 12.1 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 24.0 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.9 | 19.5 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.4 | 18.8 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.2 | 15.4 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.6 | 13.9 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.1 | 13.7 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.4 | 13.3 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.5 | 12.3 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |
| 0.5 | 11.8 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.6 | 11.6 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |