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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for UBP1

Z-value: 0.29

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Transcription factors associated with UBP1

Gene Symbol Gene ID Gene Info
ENSG00000153560.7 upstream binding protein 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
UBP1hg19_v2_chr3_-_33481835_334819050.028.0e-01Click!

Activity profile of UBP1 motif

Sorted Z-values of UBP1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_5138099 10.69 ENST00000571800.1
ENST00000574081.1
ENST00000399600.4
ENST00000574297.1
SLP adaptor and CSK interacting membrane protein
chr7_+_142498725 9.70 ENST00000466254.1
T cell receptor beta constant 2
chr22_+_22707260 7.12 ENST00000390293.1
immunoglobulin lambda variable 5-48 (non-functional)
chr6_+_32709119 6.00 ENST00000374940.3
major histocompatibility complex, class II, DQ alpha 2
chr2_-_89442621 5.11 ENST00000492167.1
immunoglobulin kappa variable 3-20
chr1_-_150208320 4.16 ENST00000534220.1
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr6_+_31555045 3.59 ENST00000396101.3
ENST00000490742.1
leukocyte specific transcript 1
chr22_+_22676808 3.45 ENST00000390290.2
immunoglobulin lambda variable 1-51
chr2_+_113033164 3.07 ENST00000409871.1
ENST00000343936.4
zinc finger CCCH-type containing 6
chr19_-_51875523 2.73 ENST00000593572.1
ENST00000595157.1
natural killer cell group 7 sequence
chr1_-_202129105 2.72 ENST00000367279.4
protein tyrosine phosphatase, non-receptor type 7
chr1_-_202129704 2.57 ENST00000476061.1
ENST00000544762.1
ENST00000467283.1
ENST00000464870.1
ENST00000435759.2
ENST00000486116.1
ENST00000543735.1
ENST00000308986.5
ENST00000477625.1
protein tyrosine phosphatase, non-receptor type 7
chr6_+_6588316 2.37 ENST00000379953.2
lymphocyte antigen 86
chr15_+_81475047 2.11 ENST00000559388.1
interleukin 16
chr5_-_111093759 2.06 ENST00000509979.1
ENST00000513100.1
ENST00000508161.1
ENST00000455559.2
neuronal regeneration related protein
chr3_+_111260954 1.93 ENST00000283285.5
CD96 molecule
chr12_-_8815299 1.93 ENST00000535336.1
microfibrillar associated protein 5
chr9_-_35685452 1.70 ENST00000607559.1
tropomyosin 2 (beta)
chr12_-_8815215 1.70 ENST00000544889.1
ENST00000543369.1
microfibrillar associated protein 5
chr3_+_111260856 1.61 ENST00000352690.4
CD96 molecule
chr4_-_57524061 1.50 ENST00000508121.1
HOP homeobox
chr21_+_43823983 1.49 ENST00000291535.6
ENST00000450356.1
ENST00000319294.6
ENST00000398367.1
ubiquitin associated and SH3 domain containing A
chr8_+_28747884 1.40 ENST00000287701.10
ENST00000444075.1
ENST00000403668.2
ENST00000519662.1
ENST00000558662.1
ENST00000523613.1
ENST00000560599.1
ENST00000397358.3
homeobox containing 1
chr19_-_54784937 1.32 ENST00000434421.1
ENST00000314446.5
ENST00000391749.4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
chrX_-_65253506 1.23 ENST00000427538.1
V-set and immunoglobulin domain containing 4
chr12_-_47473425 1.22 ENST00000550413.1
adhesion molecule with Ig-like domain 2
chr22_+_38071615 1.18 ENST00000215909.5
lectin, galactoside-binding, soluble, 1
chr11_+_10326612 1.17 ENST00000534464.1
ENST00000530439.1
ENST00000524948.1
ENST00000528655.1
ENST00000526492.1
ENST00000525063.1
adrenomedullin
chr1_-_150669604 1.13 ENST00000427665.1
ENST00000540514.1
golgi phosphoprotein 3-like
chr17_-_62493131 1.08 ENST00000539111.2
polymerase (DNA directed), gamma 2, accessory subunit
chr4_+_156588115 1.06 ENST00000455639.2
guanylate cyclase 1, soluble, alpha 3
chr22_+_22385332 1.05 ENST00000390282.2
immunoglobulin lambda variable 4-69
chr8_-_28747424 1.03 ENST00000523436.1
ENST00000397363.4
ENST00000521777.1
ENST00000520184.1
ENST00000521022.1
integrator complex subunit 9
chr8_-_66474884 1.03 ENST00000520902.1
CTD-3025N20.2
chr4_+_156587853 1.00 ENST00000506455.1
ENST00000511108.1
guanylate cyclase 1, soluble, alpha 3
chr12_+_123717458 0.98 ENST00000253233.1
chromosome 12 open reading frame 65
chr8_-_28747717 0.97 ENST00000416984.2
integrator complex subunit 9
chr1_-_152332480 0.97 ENST00000388718.5
filaggrin family member 2
chr7_+_101460882 0.95 ENST00000292535.7
ENST00000549414.2
ENST00000550008.2
ENST00000546411.2
ENST00000556210.1
cut-like homeobox 1
chr16_-_67970990 0.94 ENST00000358514.4
proteasome (prosome, macropain) subunit, beta type, 10
chr5_-_93447333 0.93 ENST00000395965.3
ENST00000505869.1
ENST00000509163.1
family with sequence similarity 172, member A
chr7_+_29874341 0.93 ENST00000409290.1
ENST00000242140.5
WAS/WASL interacting protein family, member 3
chr15_-_77712477 0.89 ENST00000560626.2
pseudopodium-enriched atypical kinase 1
chrX_+_38420623 0.88 ENST00000378482.2
tetraspanin 7
chr19_-_11039188 0.85 ENST00000588347.1
Yip1 domain family, member 2
chrX_+_13587712 0.81 ENST00000361306.1
ENST00000380602.3
EGF-like-domain, multiple 6
chr7_+_142829162 0.76 ENST00000291009.3
prolactin-induced protein
chr1_-_168698433 0.73 ENST00000367817.3
dermatopontin
chr3_+_29323043 0.71 ENST00000452462.1
ENST00000456853.1
RNA binding motif, single stranded interacting protein 3
chr4_+_156587979 0.70 ENST00000511507.1
guanylate cyclase 1, soluble, alpha 3
chr11_+_128761220 0.68 ENST00000529694.1
potassium inwardly-rectifying channel, subfamily J, member 5
chr14_-_92413727 0.63 ENST00000267620.10
fibulin 5
chr4_-_168155700 0.63 ENST00000357545.4
ENST00000512648.1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr8_+_144373550 0.59 ENST00000330143.3
ENST00000521537.1
ENST00000518432.1
ENST00000520333.1
zinc finger protein 696
chr4_-_168155730 0.55 ENST00000502330.1
ENST00000357154.3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr12_-_123717643 0.55 ENST00000541437.1
ENST00000606320.1
M-phase phosphoprotein 9
chr6_-_29395509 0.55 ENST00000377147.2
olfactory receptor, family 11, subfamily A, member 1
chr11_-_102668879 0.54 ENST00000315274.6
matrix metallopeptidase 1 (interstitial collagenase)
chr1_-_150208291 0.52 ENST00000533654.1
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr9_+_15422702 0.44 ENST00000380821.3
ENST00000421710.1
small nuclear RNA activating complex, polypeptide 3, 50kDa
chr2_+_162087577 0.43 ENST00000439442.1
TRAF family member-associated NFKB activator
chr22_+_22730353 0.41 ENST00000390296.2
immunoglobulin lambda variable 5-45
chr17_+_32683456 0.40 ENST00000225844.2
chemokine (C-C motif) ligand 13
chrX_+_24167828 0.39 ENST00000379188.3
ENST00000419690.1
ENST00000379177.1
ENST00000304543.5
zinc finger protein, X-linked
chr4_-_168155169 0.36 ENST00000534949.1
ENST00000535728.1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr4_-_47839966 0.35 ENST00000273857.4
ENST00000505909.1
ENST00000502252.1
corin, serine peptidase
chr1_-_150208412 0.34 ENST00000532744.1
ENST00000369114.5
ENST00000369115.2
ENST00000369116.4
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr4_-_76861392 0.34 ENST00000505594.1
N-acylethanolamine acid amidase
chr11_+_7506713 0.33 ENST00000329293.3
ENST00000534244.1
olfactomedin-like 1
chr12_+_9067123 0.33 ENST00000543824.1
polyhomeotic homolog 1 (Drosophila)
chr17_+_74381343 0.32 ENST00000392496.3
sphingosine kinase 1
chr11_-_113345995 0.31 ENST00000355319.2
ENST00000542616.1
dopamine receptor D2
chr1_-_114302086 0.30 ENST00000369604.1
ENST00000357783.2
putative homeodomain transcription factor 1
chr1_-_150208498 0.29 ENST00000314136.8
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr14_-_92413353 0.27 ENST00000556154.1
fibulin 5
chr1_-_150208363 0.24 ENST00000436748.2
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chrX_+_115567767 0.22 ENST00000371900.4
solute carrier family 6 (amino acid transporter), member 14
chrY_+_2803322 0.22 ENST00000383052.1
ENST00000155093.3
ENST00000449237.1
ENST00000443793.1
zinc finger protein, Y-linked
chr9_-_6015607 0.13 ENST00000259569.5
RAN binding protein 6
chr2_+_17721920 0.12 ENST00000295156.4
visinin-like 1
chr4_-_70626314 0.11 ENST00000510821.1
sulfotransferase family, cytosolic, 1B, member 1
chrX_-_70474910 0.09 ENST00000373988.1
ENST00000373998.1
zinc finger, MYM-type 3
chr13_+_24844819 0.07 ENST00000399949.2
spermatogenesis associated 13
chr3_+_111718036 0.06 ENST00000455401.2
transgelin 3
chr1_+_206223941 0.06 ENST00000367126.4
arginine vasopressin receptor 1B
chr3_-_56502375 0.06 ENST00000288221.6
ELKS/RAB6-interacting/CAST family member 2
chr2_+_61244697 0.05 ENST00000401576.1
ENST00000295030.5
ENST00000414712.2
peroxisomal biogenesis factor 13
chr14_+_21214039 0.00 ENST00000326842.2
epididymal protein 3A

Network of associatons between targets according to the STRING database.

First level regulatory network of UBP1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0002370 natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727)
0.5 2.8 GO:0052565 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.3 1.2 GO:0002317 plasma cell differentiation(GO:0002317)
0.3 2.4 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.2 1.2 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.2 1.3 GO:0002774 Fc receptor mediated inhibitory signaling pathway(GO:0002774)
0.2 5.1 GO:0003094 glomerular filtration(GO:0003094)
0.2 1.1 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.1 9.7 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 5.6 GO:0043486 histone exchange(GO:0043486)
0.1 0.3 GO:0046521 sphingoid catabolic process(GO:0046521)
0.1 0.3 GO:0044467 glial cell-derived neurotrophic factor secretion(GO:0044467) regulation of glial cell-derived neurotrophic factor secretion(GO:1900166) positive regulation of glial cell-derived neurotrophic factor secretion(GO:1900168)
0.1 2.0 GO:0016180 snRNA processing(GO:0016180)
0.1 0.4 GO:0090264 immune complex clearance(GO:0002434) immune complex clearance by monocytes and macrophages(GO:0002436) response to high density lipoprotein particle(GO:0055099) T cell extravasation(GO:0072683) regulation of immune complex clearance by monocytes and macrophages(GO:0090264)
0.1 10.7 GO:0007127 meiosis I(GO:0007127)
0.1 2.1 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.1 1.1 GO:0048194 Golgi vesicle budding(GO:0048194)
0.1 3.6 GO:0060216 definitive hemopoiesis(GO:0060216)
0.1 0.9 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 1.5 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.4 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1 1.5 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.1 0.7 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.1 1.5 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 1.4 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.1 6.0 GO:0031295 T cell costimulation(GO:0031295)
0.1 8.4 GO:0002377 immunoglobulin production(GO:0002377)
0.1 1.2 GO:0032703 negative regulation of interleukin-2 production(GO:0032703)
0.0 3.6 GO:0032945 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.0 5.2 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 1.0 GO:0061436 establishment of skin barrier(GO:0061436)
0.0 0.8 GO:0070233 negative regulation of T cell apoptotic process(GO:0070233)
0.0 3.5 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 1.0 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.5 GO:0032461 positive regulation of protein oligomerization(GO:0032461)
0.0 1.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 1.7 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 0.7 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.1 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.0 0.1 GO:0060151 peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152)
0.0 1.0 GO:0070126 mitochondrial translational termination(GO:0070126)
0.0 0.3 GO:0035812 renal sodium excretion(GO:0035812) regulation of renal sodium excretion(GO:0035813)
0.0 0.9 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.1 GO:0071748 IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751)
1.1 10.7 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.3 6.0 GO:0042613 MHC class II protein complex(GO:0042613)
0.3 5.6 GO:0000812 Swr1 complex(GO:0000812)
0.2 2.0 GO:0032039 integrator complex(GO:0032039)
0.2 9.7 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.2 3.6 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 0.9 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 0.9 GO:0071953 elastic fiber(GO:0071953)
0.1 2.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 1.7 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 1.4 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 1.0 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.3 GO:0035102 PRC1 complex(GO:0035102)
0.0 1.1 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 5.3 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 1.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.0 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 4.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.0 GO:0032395 MHC class II receptor activity(GO:0032395)
0.4 1.2 GO:0048030 disaccharide binding(GO:0048030)
0.3 1.0 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.2 9.7 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.2 1.3 GO:0032396 inhibitory MHC class I receptor activity(GO:0032396)
0.1 1.4 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.1 0.4 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 0.7 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
0.1 2.8 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 5.6 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.1 2.1 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 0.4 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 1.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 10.0 GO:0003823 antigen binding(GO:0003823)
0.1 1.1 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 0.3 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.0 0.8 GO:0019864 IgG binding(GO:0019864)
0.0 0.3 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 5.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 1.1 GO:0034061 DNA-directed DNA polymerase activity(GO:0003887) DNA polymerase activity(GO:0034061)
0.0 3.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.9 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 1.7 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.2 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 1.7 GO:0005178 integrin binding(GO:0005178)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 3.6 PID NOTCH PATHWAY Notch signaling pathway
0.0 1.5 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.2 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.0 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 0.3 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.4 ST ADRENERGIC Adrenergic Pathway
0.0 0.5 PID ENDOTHELIN PATHWAY Endothelins
0.0 1.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.0 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 4.9 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 2.8 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 1.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.0 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.5 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.7 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 2.4 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.0 0.9 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.0 0.4 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 1.2 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.2 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters