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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for UCACAGU
Z-value: 0.35
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miRNA associated with seed UCACAGU
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_+_64708615 Show fit | 15.23 |
ENST00000338957.4
ENST00000423889.3 |
zinc finger CCCH-type containing 12B |
|
| chr20_+_10199468 Show fit | 11.04 |
ENST00000254976.2
ENST00000304886.2 |
synaptosomal-associated protein, 25kDa |
|
| chr10_-_21786179 Show fit | 9.38 |
ENST00000377113.5
|
cancer susceptibility candidate 10 |
|
| chr16_-_4292071 Show fit | 7.37 |
ENST00000399609.3
|
sarcalumenin |
|
| chr8_+_80523321 Show fit | 7.34 |
ENST00000518111.1
|
stathmin-like 2 |
|
| chr16_-_70719925 Show fit | 6.73 |
ENST00000338779.6
|
metastasis suppressor 1-like |
|
| chr12_-_105478339 Show fit | 6.61 |
ENST00000424857.2
ENST00000258494.9 |
aldehyde dehydrogenase 1 family, member L2 |
|
| chr12_+_79258547 Show fit | 6.13 |
ENST00000457153.2
|
synaptotagmin I |
|
| chr2_-_100939195 Show fit | 6.07 |
ENST00000393437.3
|
LON peptidase N-terminal domain and ring finger 2 |
|
| chr10_+_104474207 Show fit | 6.02 |
ENST00000602831.1
ENST00000369893.5 |
sideroflexin 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of UCACAGU
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 9.7 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 0.1 | 8.0 | GO:0042795 | snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795) |
| 1.8 | 7.3 | GO:0031117 | positive regulation of microtubule depolymerization(GO:0031117) |
| 0.2 | 6.7 | GO:0097178 | ruffle assembly(GO:0097178) |
| 2.2 | 6.6 | GO:0009258 | 10-formyltetrahydrofolate catabolic process(GO:0009258) |
| 0.0 | 6.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 2.0 | 6.1 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.1 | 5.3 | GO:0055072 | iron ion homeostasis(GO:0055072) |
| 0.2 | 5.2 | GO:0047497 | establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497) |
| 1.0 | 5.0 | GO:0090258 | negative regulation of mitochondrial fission(GO:0090258) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.7 | GO:0030426 | growth cone(GO:0030426) |
| 2.8 | 11.0 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.1 | 9.1 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.2 | 8.2 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 7.7 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 7.5 | GO:0030424 | axon(GO:0030424) |
| 0.7 | 7.4 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.1 | 6.9 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 6.6 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 1.2 | 6.1 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 11.0 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 10.1 | GO:0004519 | endonuclease activity(GO:0004519) |
| 0.2 | 8.5 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.2 | 8.1 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.1 | 7.3 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.1 | 7.0 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 2.2 | 6.6 | GO:0016155 | formyltetrahydrofolate dehydrogenase activity(GO:0016155) |
| 1.2 | 6.1 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.3 | 5.7 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
| 0.4 | 5.4 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 21.8 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.2 | 7.6 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 5.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 4.7 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 4.3 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 4.3 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 4.3 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 3.4 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 3.2 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.0 | 3.2 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 17.2 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.3 | 8.6 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 8.0 | REACTOME RNA POL II PRE TRANSCRIPTION EVENTS | Genes involved in RNA Polymerase II Pre-transcription Events |
| 0.1 | 6.6 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 5.8 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.2 | 5.2 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.2 | 5.0 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 4.3 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 4.3 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.2 | 4.1 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |