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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for UCACAUU
Z-value: 0.48
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miRNA associated with seed UCACAUU
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_174256276 Show fit | 12.26 |
ENST00000296503.5
|
high mobility group box 2 |
|
| chr12_+_104682496 Show fit | 12.16 |
ENST00000378070.4
|
thioredoxin reductase 1 |
|
| chr17_-_62658186 Show fit | 9.45 |
ENST00000262435.9
|
SMAD specific E3 ubiquitin protein ligase 2 |
|
| chr5_+_82767284 Show fit | 9.04 |
ENST00000265077.3
|
versican |
|
| chr17_+_37026106 Show fit | 7.77 |
ENST00000318008.6
|
LIM and SH3 protein 1 |
|
| chr12_-_76953284 Show fit | 7.76 |
ENST00000547544.1
ENST00000393249.2 |
oxysterol binding protein-like 8 |
|
| chr5_+_162864575 Show fit | 7.61 |
ENST00000512163.1
ENST00000393929.1 ENST00000340828.2 ENST00000511683.2 ENST00000510097.1 ENST00000511490.2 ENST00000510664.1 |
cyclin G1 |
|
| chr12_-_46662772 Show fit | 7.23 |
ENST00000549049.1
ENST00000439706.1 ENST00000398637.5 |
solute carrier family 38, member 1 |
|
| chr17_-_29151794 Show fit | 7.21 |
ENST00000324238.6
|
cytokine receptor-like factor 3 |
|
| chr5_+_65222299 Show fit | 6.61 |
ENST00000284037.5
|
erbb2 interacting protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of UCACAUU
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 13.7 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 1.2 | 12.3 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
| 1.4 | 12.2 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
| 2.4 | 9.5 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 1.1 | 7.8 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
| 0.2 | 7.2 | GO:0001504 | neurotransmitter uptake(GO:0001504) |
| 0.5 | 6.5 | GO:0040016 | embryonic cleavage(GO:0040016) |
| 0.1 | 6.5 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 0.4 | 6.1 | GO:0036500 | ATF6-mediated unfolded protein response(GO:0036500) |
| 0.1 | 6.1 | GO:0031640 | killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.8 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.0 | 13.2 | GO:0000785 | chromatin(GO:0000785) |
| 0.1 | 12.8 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 11.7 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.1 | 10.9 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.1 | 9.9 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 9.5 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.5 | 8.8 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 1.2 | 8.4 | GO:0031415 | NatA complex(GO:0031415) |
| 0.6 | 7.1 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 12.3 | GO:0044378 | non-sequence-specific DNA binding, bending(GO:0044378) |
| 4.1 | 12.2 | GO:0098626 | methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626) |
| 0.5 | 10.4 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.3 | 9.1 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 8.7 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.6 | 8.4 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.0 | 7.8 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 7.7 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.5 | 6.8 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.2 | 6.8 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 12.0 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 10.9 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.1 | 9.5 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.2 | 7.6 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 7.0 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 6.6 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 6.0 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 4.9 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 4.5 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 4.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 14.9 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.5 | 14.1 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.2 | 12.7 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.6 | 12.4 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.4 | 12.2 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.2 | 9.0 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.4 | 8.9 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.3 | 7.9 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.4 | 6.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.2 | 6.0 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |