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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for UCCAGUU
Z-value: 0.90
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miRNA associated with seed UCCAGUU
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_159893507 Show fit | 25.89 |
ENST00000368096.1
|
transgelin 2 |
|
| chr8_+_98656336 Show fit | 25.42 |
ENST00000336273.3
|
metadherin |
|
| chr12_-_92539614 Show fit | 23.07 |
ENST00000256015.3
|
B-cell translocation gene 1, anti-proliferative |
|
| chr1_+_86046433 Show fit | 22.94 |
ENST00000451137.2
|
cysteine-rich, angiogenic inducer, 61 |
|
| chr18_+_3247413 Show fit | 21.41 |
ENST00000579226.1
ENST00000217652.3 |
myosin, light chain 12A, regulatory, non-sarcomeric |
|
| chr11_-_102323489 Show fit | 20.70 |
ENST00000361236.3
|
transmembrane protein 123 |
|
| chr3_+_180630090 Show fit | 18.30 |
ENST00000357559.4
ENST00000305586.7 |
fragile X mental retardation, autosomal homolog 1 |
|
| chr19_-_2456922 Show fit | 17.28 |
ENST00000582871.1
ENST00000325327.3 |
lamin B2 |
|
| chr2_+_114647504 Show fit | 17.15 |
ENST00000263238.2
|
ARP3 actin-related protein 3 homolog (yeast) |
|
| chr1_-_94374946 Show fit | 16.11 |
ENST00000370238.3
|
glutamate-cysteine ligase, modifier subunit |
Network of associatons between targets according to the STRING database.
First level regulatory network of UCCAGUU
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 40.6 | GO:0002576 | platelet degranulation(GO:0002576) |
| 0.6 | 39.1 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 0.3 | 27.2 | GO:0070527 | platelet aggregation(GO:0070527) |
| 3.8 | 23.1 | GO:0060136 | embryonic process involved in female pregnancy(GO:0060136) |
| 1.8 | 23.1 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 2.9 | 22.9 | GO:0003278 | apoptotic process involved in heart morphogenesis(GO:0003278) |
| 2.4 | 22.0 | GO:0032534 | regulation of microvillus assembly(GO:0032534) |
| 2.2 | 21.6 | GO:2000643 | positive regulation of early endosome to late endosome transport(GO:2000643) |
| 0.1 | 21.6 | GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 1.3 | 20.7 | GO:0045793 | positive regulation of cell size(GO:0045793) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 34.5 | GO:0005811 | lipid particle(GO:0005811) |
| 0.3 | 25.5 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 3.6 | 25.4 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 1.3 | 24.9 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.3 | 24.6 | GO:0016459 | myosin complex(GO:0016459) |
| 0.2 | 21.1 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 2.3 | 20.4 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.2 | 19.4 | GO:0015934 | large ribosomal subunit(GO:0015934) |
| 0.4 | 18.3 | GO:0043034 | costamere(GO:0043034) |
| 0.2 | 18.1 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 57.9 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 42.0 | GO:0003712 | transcription cofactor activity(GO:0003712) |
| 0.1 | 41.7 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.9 | 32.6 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.3 | 26.5 | GO:0019003 | GDP binding(GO:0019003) |
| 0.2 | 25.5 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.7 | 25.4 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.2 | 24.4 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 1.7 | 22.2 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 1.7 | 18.8 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 40.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 32.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 30.3 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.4 | 28.6 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.5 | 26.2 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.4 | 22.7 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.7 | 20.2 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.9 | 16.9 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.2 | 16.6 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 16.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 31.1 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.6 | 24.7 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.1 | 17.5 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.4 | 16.1 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.3 | 15.0 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.2 | 14.5 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 1.0 | 14.1 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.3 | 13.0 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.2 | 12.8 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.4 | 12.2 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |