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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for UGAAAUG
Z-value: 0.92
Network of associatons between targets according to the STRING database.
First level regulatory network of UGAAAUG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.2 | GO:0071431 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 1.1 | 4.2 | GO:0019860 | dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) transformation of host cell by virus(GO:0019087) uracil metabolic process(GO:0019860) |
| 0.4 | 4.0 | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387) |
| 0.1 | 3.6 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 1.1 | 3.3 | GO:0045210 | FasL biosynthetic process(GO:0045210) |
| 0.4 | 2.7 | GO:2000483 | negative regulation of interleukin-8 secretion(GO:2000483) |
| 0.3 | 2.7 | GO:0070601 | centromeric sister chromatid cohesion(GO:0070601) |
| 0.9 | 2.6 | GO:0070563 | negative regulation of vitamin D receptor signaling pathway(GO:0070563) |
| 0.8 | 2.5 | GO:0018103 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.2 | 2.5 | GO:0010839 | negative regulation of keratinocyte proliferation(GO:0010839) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 6.2 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.0 | 4.7 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.3 | 4.6 | GO:0005652 | nuclear lamina(GO:0005652) |
| 0.1 | 4.1 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.3 | 3.5 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.0 | 3.0 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 2.8 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.1 | 2.7 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.4 | 2.5 | GO:0031415 | NatA complex(GO:0031415) |
| 0.0 | 2.3 | GO:0035578 | azurophil granule lumen(GO:0035578) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.2 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 0.1 | 4.0 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.2 | 3.3 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.0 | 3.2 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.1 | 2.9 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.1 | 2.9 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 0.6 | 2.8 | GO:0098639 | collagen binding involved in cell-matrix adhesion(GO:0098639) |
| 0.1 | 2.7 | GO:0004859 | phospholipase inhibitor activity(GO:0004859) |
| 0.0 | 2.7 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.2 | 2.5 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.5 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.1 | 3.8 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 3.2 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 2.7 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 2.6 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 2.5 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 2.3 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 2.2 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 2.1 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 2.1 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.9 | REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT | Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript |
| 0.2 | 5.6 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.1 | 3.9 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.1 | 2.6 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 2.5 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.1 | 2.2 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.0 | 2.1 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.1 | 2.0 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.1 | 1.9 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.1 | 1.9 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |