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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for UGACAUC

Z-value: 0.30

Motif logo

logo of

miRNA associated with seed UGACAUC

NamemiRBASE accession
hsa-miR-489-3p
MIMAT0002805

Activity profile of UGACAUC motif

Sorted Z-values of UGACAUC motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_46668994 1.47 ENST00000371980.3
LURAP1
leucine rich adaptor protein 1
chr8_+_56014949 1.23 ENST00000327381.6
XKR4
XK, Kell blood group complex subunit-related family, member 4
chr18_+_21693306 1.21 ENST00000540918.2
TTC39C
tetratricopeptide repeat domain 39C
chr2_-_100939195 0.98 ENST00000393437.3
LONRF2
LON peptidase N-terminal domain and ring finger 2
chr2_+_203499901 0.86 ENST00000303116.6
ENST00000392238.2
FAM117B
family with sequence similarity 117, member B
chr2_+_30369807 0.85 ENST00000379520.3
ENST00000379519.3
ENST00000261353.4
YPEL5
yippee-like 5 (Drosophila)
chr12_+_32112340 0.82 ENST00000540924.1
ENST00000312561.4
KIAA1551
KIAA1551
chr6_+_116601265 0.56 ENST00000452085.3
DSE
dermatan sulfate epimerase
chr10_+_70480963 0.54 ENST00000265872.6
ENST00000535016.1
ENST00000538031.1
ENST00000543719.1
ENST00000539539.1
ENST00000543225.1
ENST00000536012.1
ENST00000494903.2
CCAR1
cell division cycle and apoptosis regulator 1
chr18_-_65184217 0.49 ENST00000310045.7
DSEL
dermatan sulfate epimerase-like
chr7_-_138666053 0.40 ENST00000440172.1
ENST00000422774.1
KIAA1549
KIAA1549
chr2_+_61404624 0.37 ENST00000394457.3
AHSA2
AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)
chr6_-_24911195 0.35 ENST00000259698.4
FAM65B
family with sequence similarity 65, member B
chr9_-_94186131 0.34 ENST00000297689.3
NFIL3
nuclear factor, interleukin 3 regulated
chr6_-_99873145 0.31 ENST00000369239.5
ENST00000438806.1
PNISR
PNN-interacting serine/arginine-rich protein
chr21_-_16437255 0.30 ENST00000400199.1
ENST00000400202.1
NRIP1
nuclear receptor interacting protein 1
chr16_+_50187556 0.27 ENST00000561678.1
ENST00000357464.3
PAPD5
PAP associated domain containing 5
chr2_-_27938593 0.27 ENST00000379677.2
AC074091.13
Uncharacterized protein
chr5_-_131132614 0.27 ENST00000307968.7
ENST00000307954.8
FNIP1
folliculin interacting protein 1
chrX_+_110339439 0.26 ENST00000372010.1
ENST00000519681.1
ENST00000372007.5
PAK3
p21 protein (Cdc42/Rac)-activated kinase 3
chrX_+_64887512 0.26 ENST00000360270.5
MSN
moesin
chr5_+_109025067 0.25 ENST00000261483.4
MAN2A1
mannosidase, alpha, class 2A, member 1
chr13_-_77900814 0.24 ENST00000544440.2
MYCBP2
MYC binding protein 2, E3 ubiquitin protein ligase
chr17_-_36981556 0.24 ENST00000536127.1
ENST00000225428.5
CWC25
CWC25 spliceosome-associated protein homolog (S. cerevisiae)
chr9_+_82186872 0.23 ENST00000376544.3
ENST00000376520.4
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr18_+_22006580 0.22 ENST00000284202.4
IMPACT
impact RWD domain protein
chr12_-_123011536 0.21 ENST00000331738.7
ENST00000354654.2
RSRC2
arginine/serine-rich coiled-coil 2
chr5_-_107006596 0.21 ENST00000333274.6
EFNA5
ephrin-A5
chr2_-_161350305 0.20 ENST00000348849.3
RBMS1
RNA binding motif, single stranded interacting protein 1
chr4_-_153457197 0.19 ENST00000281708.4
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr1_+_91966384 0.18 ENST00000430031.2
ENST00000234626.6
CDC7
cell division cycle 7
chr10_+_112679301 0.18 ENST00000265277.5
ENST00000369452.4
SHOC2
soc-2 suppressor of clear homolog (C. elegans)
chr1_+_32573636 0.17 ENST00000373625.3
KPNA6
karyopherin alpha 6 (importin alpha 7)
chr10_+_11206925 0.16 ENST00000354440.2
ENST00000315874.4
ENST00000427450.1
CELF2
CUGBP, Elav-like family member 2
chr14_+_70078303 0.16 ENST00000342745.4
KIAA0247
KIAA0247
chr16_-_21663950 0.16 ENST00000268389.4
IGSF6
immunoglobulin superfamily, member 6
chr11_-_31839488 0.15 ENST00000419022.1
ENST00000379132.3
ENST00000379129.2
PAX6
paired box 6
chr11_-_132813566 0.15 ENST00000331898.7
OPCML
opioid binding protein/cell adhesion molecule-like
chr14_-_37642016 0.14 ENST00000331299.5
SLC25A21
solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
chr2_-_25475120 0.14 ENST00000380746.4
ENST00000402667.1
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr7_+_31092076 0.14 ENST00000304166.4
ADCYAP1R1
adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
chr12_+_60083118 0.13 ENST00000261187.4
ENST00000543448.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr6_-_39197226 0.13 ENST00000359534.3
KCNK5
potassium channel, subfamily K, member 5
chr1_+_28995231 0.13 ENST00000373816.1
GMEB1
glucocorticoid modulatory element binding protein 1
chr16_-_62070305 0.12 ENST00000584337.1
CDH8
cadherin 8, type 2
chr9_-_6015607 0.12 ENST00000259569.5
RANBP6
RAN binding protein 6
chr5_+_135364584 0.11 ENST00000442011.2
ENST00000305126.8
TGFBI
transforming growth factor, beta-induced, 68kDa
chr19_-_7293942 0.11 ENST00000341500.5
ENST00000302850.5
INSR
insulin receptor
chr5_-_140998616 0.11 ENST00000389054.3
ENST00000398562.2
ENST00000389057.5
ENST00000398566.3
ENST00000398557.4
ENST00000253811.6
DIAPH1
diaphanous-related formin 1
chr14_+_57046500 0.11 ENST00000261556.6
TMEM260
transmembrane protein 260
chr1_+_50574585 0.11 ENST00000371824.1
ENST00000371823.4
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr1_-_114355083 0.11 ENST00000261441.5
RSBN1
round spermatid basic protein 1
chr9_+_77703414 0.10 ENST00000346234.6
OSTF1
osteoclast stimulating factor 1
chr18_+_32558208 0.10 ENST00000436190.2
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chrX_-_77041685 0.10 ENST00000373344.5
ENST00000395603.3
ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr16_-_2264779 0.10 ENST00000333503.7
PGP
phosphoglycolate phosphatase
chr17_+_54911444 0.10 ENST00000284061.3
ENST00000572810.1
DGKE
diacylglycerol kinase, epsilon 64kDa
chr1_-_22109682 0.09 ENST00000400301.1
ENST00000532737.1
USP48
ubiquitin specific peptidase 48
chr15_-_61521495 0.09 ENST00000335670.6
RORA
RAR-related orphan receptor A
chr1_+_65730385 0.09 ENST00000263441.7
ENST00000395325.3
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr8_+_30891298 0.08 ENST00000298139.5
WRN
Werner syndrome, RecQ helicase-like
chr5_-_98262240 0.08 ENST00000284049.3
CHD1
chromodomain helicase DNA binding protein 1
chr6_-_100912785 0.08 ENST00000369208.3
SIM1
single-minded family bHLH transcription factor 1
chr6_+_35995488 0.08 ENST00000229795.3
MAPK14
mitogen-activated protein kinase 14
chr18_+_49866496 0.08 ENST00000442544.2
DCC
deleted in colorectal carcinoma
chr14_-_45431091 0.08 ENST00000579157.1
ENST00000396128.4
ENST00000556500.1
KLHL28
kelch-like family member 28
chr11_-_106889250 0.08 ENST00000526355.2
GUCY1A2
guanylate cyclase 1, soluble, alpha 2
chr2_+_28974668 0.08 ENST00000296122.6
ENST00000395366.2
PPP1CB
protein phosphatase 1, catalytic subunit, beta isozyme
chr15_+_62853562 0.07 ENST00000561311.1
TLN2
talin 2
chr9_-_135819987 0.07 ENST00000298552.3
ENST00000403810.1
TSC1
tuberous sclerosis 1
chr1_-_213189108 0.07 ENST00000535388.1
ANGEL2
angel homolog 2 (Drosophila)
chr14_+_79745746 0.07 ENST00000281127.7
NRXN3
neurexin 3
chr11_+_118307179 0.07 ENST00000534358.1
ENST00000531904.2
ENST00000389506.5
ENST00000354520.4
KMT2A
lysine (K)-specific methyltransferase 2A
chr6_-_114292449 0.06 ENST00000519065.1
HDAC2
histone deacetylase 2
chr21_-_15755446 0.06 ENST00000544452.1
ENST00000285667.3
HSPA13
heat shock protein 70kDa family, member 13
chr3_-_113465065 0.06 ENST00000497255.1
ENST00000478020.1
ENST00000240922.3
ENST00000493900.1
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr1_-_108507631 0.06 ENST00000527011.1
ENST00000370056.4
VAV3
vav 3 guanine nucleotide exchange factor
chr12_+_54943134 0.06 ENST00000243052.3
PDE1B
phosphodiesterase 1B, calmodulin-dependent
chrX_+_122993827 0.06 ENST00000371199.3
XIAP
X-linked inhibitor of apoptosis
chr8_-_72987810 0.06 ENST00000262209.4
TRPA1
transient receptor potential cation channel, subfamily A, member 1
chr15_+_68570062 0.05 ENST00000306917.4
FEM1B
fem-1 homolog b (C. elegans)
chr3_+_145782358 0.05 ENST00000422482.1
AC107021.1
HCG1786590; PRO2533; Uncharacterized protein
chr1_-_84464780 0.05 ENST00000260505.8
TTLL7
tubulin tyrosine ligase-like family, member 7
chr1_+_201252580 0.05 ENST00000367324.3
ENST00000263946.3
PKP1
plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)
chr6_-_139695757 0.05 ENST00000367651.2
CITED2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr3_-_182698381 0.05 ENST00000292782.4
DCUN1D1
DCN1, defective in cullin neddylation 1, domain containing 1
chr6_+_21593972 0.05 ENST00000244745.1
ENST00000543472.1
SOX4
SRY (sex determining region Y)-box 4
chr2_+_166095898 0.04 ENST00000424833.1
ENST00000375437.2
ENST00000357398.3
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr11_+_105480793 0.04 ENST00000282499.5
ENST00000393127.2
ENST00000527669.1
GRIA4
glutamate receptor, ionotropic, AMPA 4
chr20_+_49348081 0.04 ENST00000371610.2
PARD6B
par-6 family cell polarity regulator beta
chr3_-_72496035 0.04 ENST00000477973.2
RYBP
RING1 and YY1 binding protein
chr3_+_45636219 0.04 ENST00000273317.4
LIMD1
LIM domains containing 1
chr9_+_91003271 0.03 ENST00000375859.3
ENST00000541629.1
SPIN1
spindlin 1
chr9_+_120466650 0.03 ENST00000355622.6
TLR4
toll-like receptor 4
chr10_+_98741041 0.03 ENST00000286067.2
C10orf12
chromosome 10 open reading frame 12
chr15_+_59279851 0.03 ENST00000348370.4
ENST00000434298.1
ENST00000559160.1
RNF111
ring finger protein 111
chr8_+_28351707 0.03 ENST00000537916.1
ENST00000523546.1
ENST00000240093.3
FZD3
frizzled family receptor 3
chr7_+_107110488 0.03 ENST00000304402.4
GPR22
G protein-coupled receptor 22
chr2_-_178937478 0.03 ENST00000286063.6
PDE11A
phosphodiesterase 11A
chr19_-_46476791 0.03 ENST00000263257.5
NOVA2
neuro-oncological ventral antigen 2
chr20_+_47538357 0.02 ENST00000371917.4
ARFGEF2
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr12_-_54673871 0.02 ENST00000209875.4
CBX5
chromobox homolog 5
chr16_+_53088885 0.02 ENST00000566029.1
ENST00000447540.1
CHD9
chromodomain helicase DNA binding protein 9
chr7_+_43152191 0.02 ENST00000395891.2
HECW1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr2_+_166326157 0.02 ENST00000421875.1
ENST00000314499.7
ENST00000409664.1
CSRNP3
cysteine-serine-rich nuclear protein 3
chr6_+_163148161 0.02 ENST00000337019.3
ENST00000366889.2
PACRG
PARK2 co-regulated
chr16_+_24266874 0.02 ENST00000005284.3
CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr18_+_22040593 0.02 ENST00000256906.4
HRH4
histamine receptor H4
chr20_-_9819479 0.02 ENST00000378423.1
ENST00000353224.5
PAK7
p21 protein (Cdc42/Rac)-activated kinase 7
chr5_+_138629417 0.02 ENST00000510056.1
ENST00000511249.1
ENST00000503811.1
ENST00000511378.1
MATR3
matrin 3
chr17_+_59529743 0.02 ENST00000589003.1
ENST00000393853.4
TBX4
T-box 4
chr3_+_29322803 0.02 ENST00000396583.3
ENST00000383767.2
RBMS3
RNA binding motif, single stranded interacting protein 3
chr1_+_206808918 0.01 ENST00000367108.3
DYRK3
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
chr1_-_161147275 0.01 ENST00000319769.5
ENST00000367998.1
B4GALT3
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
chr2_-_27886676 0.01 ENST00000337768.5
SUPT7L
suppressor of Ty 7 (S. cerevisiae)-like
chr2_+_198318147 0.01 ENST00000263960.2
COQ10B
coenzyme Q10 homolog B (S. cerevisiae)
chr18_+_9913977 0.01 ENST00000400000.2
ENST00000340541.4
VAPA
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
chr2_-_38978492 0.01 ENST00000409276.1
ENST00000446327.2
ENST00000313117.6
SRSF7
serine/arginine-rich splicing factor 7
chr8_-_77912431 0.01 ENST00000357039.4
ENST00000522527.1
PEX2
peroxisomal biogenesis factor 2
chr10_+_111967345 0.01 ENST00000332674.5
ENST00000453116.1
MXI1
MAX interactor 1, dimerization protein
chr12_-_29534074 0.00 ENST00000546839.1
ENST00000360150.4
ENST00000552155.1
ENST00000550353.1
ENST00000548441.1
ENST00000552132.1
ERGIC2
ERGIC and golgi 2
chr4_-_111544254 0.00 ENST00000306732.3
PITX2
paired-like homeodomain 2
chr7_-_41742697 0.00 ENST00000242208.4
INHBA
inhibin, beta A
chr1_-_70671216 0.00 ENST00000370952.3
LRRC40
leucine rich repeat containing 40
chr4_-_53525406 0.00 ENST00000451218.2
ENST00000441222.3
USP46
ubiquitin specific peptidase 46

Network of associatons between targets according to the STRING database.

First level regulatory network of UGACAUC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0002904 positive regulation of B cell apoptotic process(GO:0002904)
0.1 0.2 GO:0032058 positive regulation of translational initiation in response to stress(GO:0032058)
0.0 0.3 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 1.1 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.3 GO:0043634 polyadenylation-dependent ncRNA catabolic process(GO:0043634)
0.0 0.2 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.0 0.3 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.3 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 0.2 GO:0003322 pancreatic A cell development(GO:0003322)
0.0 0.1 GO:1990535 transformation of host cell by virus(GO:0019087) neuron projection maintenance(GO:1990535)
0.0 0.0 GO:0045976 negative regulation of mitotic cell cycle, embryonic(GO:0045976)
0.0 0.1 GO:0006114 glycerol biosynthetic process(GO:0006114)
0.0 0.1 GO:0015742 alpha-ketoglutarate transport(GO:0015742)
0.0 0.1 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.0 0.3 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.0 0.2 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.1 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.0 0.1 GO:1902530 regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530)
0.0 0.1 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.0 0.1 GO:1901674 histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.0 0.1 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.1 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.0 0.1 GO:0051029 rRNA transport(GO:0051029)
0.0 0.1 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.1 GO:0061198 fungiform papilla formation(GO:0061198)
0.0 0.0 GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.0 0.1 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.0 GO:0035910 N-terminal peptidyl-lysine acetylation(GO:0018076) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.0 0.1 GO:0050968 thermoception(GO:0050955) detection of chemical stimulus involved in sensory perception of pain(GO:0050968)
0.0 0.3 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.0 0.1 GO:0016191 synaptic vesicle uncoating(GO:0016191)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.2 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.1 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 0.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.3 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 1.5 GO:0042641 actomyosin(GO:0042641)
0.0 0.1 GO:0032389 MutLalpha complex(GO:0032389)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.1 0.2 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.1 0.3 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.3 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.1 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.1 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.1 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.0 1.0 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.1 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.2 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0045322 unmethylated CpG binding(GO:0045322)
0.0 0.3 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.1 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.1 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.0 0.1 GO:0043559 insulin binding(GO:0043559)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.1 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.1 GO:0017018 myosin phosphatase activity(GO:0017018)
0.0 0.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.4 GO:0001671 ATPase activator activity(GO:0001671)