ISMARA results: UGCAGUC

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for UGCAGUC

Z-value: 0.04

Motif logo

miRNA associated with seed UGCAGUC

Name	miRBASE accession
hsa-miR-455-3p.2 miRBase

Activity profile of UGCAGUC motif

Sorted Z-values of UGCAGUC motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_149632783 Show fit	2.75	ENST00000435030.1	KIF5C Ensembl NCBI GeneCards UniProt NextProt Show fit	kinesin family member 5C
chr6_-_46293378 Show fit	2.71	ENST00000330430.6	RCAN2 Ensembl NCBI GeneCards UniProt NextProt Show fit	regulator of calcineurin 2
chr14_+_100150622 Show fit	2.52	ENST00000261835.3	CYP46A1 Ensembl NCBI GeneCards UniProt NextProt Show fit	cytochrome P450, family 46, subfamily A, polypeptide 1
chr2_-_2334888 Show fit	2.18	ENST00000428368.2 ENST00000399161.2	MYT1L Ensembl NCBI GeneCards UniProt NextProt Show fit	myelin transcription factor 1-like
chr11_-_134281812 Show fit	2.15	ENST00000392580.1 ENST00000312527.4	B3GAT1 Ensembl NCBI GeneCards UniProt NextProt Show fit	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
chr12_-_16761007 Show fit	2.14	ENST00000354662.1 ENST00000441439.2	LMO3 Ensembl NCBI GeneCards UniProt NextProt Show fit	LIM domain only 3 (rhombotin-like 2)
chr14_+_93389425 Show fit	1.73	ENST00000216492.5 ENST00000334654.4	CHGA Ensembl NCBI GeneCards UniProt NextProt Show fit	chromogranin A (parathyroid secretory protein 1)
chr2_-_169104651 Show fit	1.54	ENST00000355999.4	STK39 Ensembl NCBI GeneCards UniProt NextProt Show fit	serine threonine kinase 39
chr17_-_78450398 Show fit	1.50	ENST00000306773.4	NPTX1 Ensembl NCBI GeneCards UniProt NextProt Show fit	neuronal pentraxin I
chr1_-_70671216 Show fit	1.48	ENST00000370952.3	LRRC40 Ensembl NCBI GeneCards UniProt NextProt Show fit	leucine rich repeat containing 40

Showing 1 to 10 of 99 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of UGCAGUC

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.0	GO:0008045	motor neuron axon guidance(GO:0008045)
0.1	2.7	GO:0070884	regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.3	2.5	GO:0016127	cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.7	2.1	GO:0023016	signal transduction by trans-phosphorylation(GO:0023016)
0.4	2.1	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0	2.0	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.1	1.9	GO:0048665	neuron fate specification(GO:0048665)
0.6	1.7	GO:2000705	dense core granule biogenesis(GO:0061110) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705)
0.4	1.5	GO:0072660	positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.2	1.5	GO:0060385	axonogenesis involved in innervation(GO:0060385)

Showing 1 to 10 of 50 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.8	GO:0035253	ciliary rootlet(GO:0035253)
0.1	2.2	GO:0042583	chromaffin granule(GO:0042583)
0.1	2.1	GO:0005868	cytoplasmic dynein complex(GO:0005868)
0.0	2.0	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.1	1.5	GO:0043194	axon initial segment(GO:0043194)
0.1	1.3	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	1.1	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	1.1	GO:0005720	nuclear heterochromatin(GO:0005720)
0.0	0.9	GO:0045171	intercellular bridge(GO:0045171)
0.2	0.8	GO:0044308	axonal spine(GO:0044308)

Showing 1 to 10 of 32 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.5	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.5	2.7	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1	2.5	GO:0008395	steroid hydroxylase activity(GO:0008395)
0.7	2.1	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.1	1.7	GO:0000339	RNA cap binding(GO:0000339)
0.0	1.5	GO:0030507	spectrin binding(GO:0030507)
0.0	1.4	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.2	1.3	GO:0045504	dynein heavy chain binding(GO:0045504)
0.0	1.2	GO:0031489	myosin V binding(GO:0031489)
0.1	1.1	GO:0050811	GABA receptor binding(GO:0050811)

Showing 1 to 10 of 42 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.0	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	1.5	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	1.4	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.1	1.1	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	1.1	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	1.1	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	1.0	PID AURORA A PATHWAY	Aurora A signaling
0.0	1.0	PID EPHB FWD PATHWAY	EPHB forward signaling
0.0	1.0	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.0	0.6	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway

Showing 1 to 10 of 13 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	2.5	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1	2.3	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1	2.0	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0	1.8	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.0	1.5	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	1.5	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1	1.1	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	1.1	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.0	0.8	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	0.8	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins

Showing 1 to 10 of 16 entries

Results for UGCAGUC

Z-value: 0.04

Motif logo

miRNA associated with seed UGCAGUC

Activity profile of UGCAGUC motif

Sorted Z-values of UGCAGUC motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of UGCAGUC

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: