Project
GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for UGGCACU
Z-value: 0.08
Network of associatons between targets according to the STRING database.
First level regulatory network of UGGCACU
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 10.5 | GO:0090170 | regulation of Golgi inheritance(GO:0090170) |
| 0.3 | 7.6 | GO:0061099 | negative regulation of protein tyrosine kinase activity(GO:0061099) |
| 1.1 | 6.9 | GO:0022614 | membrane to membrane docking(GO:0022614) |
| 2.2 | 6.6 | GO:0097327 | response to antineoplastic agent(GO:0097327) |
| 0.0 | 6.6 | GO:0006469 | negative regulation of protein kinase activity(GO:0006469) |
| 0.4 | 5.7 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 0.1 | 5.4 | GO:0006656 | phosphatidylcholine biosynthetic process(GO:0006656) |
| 1.3 | 5.3 | GO:0033387 | putrescine biosynthetic process from ornithine(GO:0033387) |
| 0.1 | 5.1 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.1 | 5.0 | GO:0070534 | protein K63-linked ubiquitination(GO:0070534) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.3 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 10.8 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.4 | 7.2 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.5 | 6.6 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.3 | 5.8 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.1 | 5.3 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 5.0 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 4.8 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 1.2 | 4.7 | GO:0032144 | 4-aminobutyrate transaminase complex(GO:0032144) |
| 0.2 | 4.7 | GO:0001931 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 12.7 | GO:0010858 | calcium-dependent protein kinase regulator activity(GO:0010858) |
| 0.1 | 10.6 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 10.5 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.3 | 9.7 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.5 | 6.6 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.3 | 6.4 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.1 | 6.2 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 6.1 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 5.7 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.1 | 5.4 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 11.4 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 11.1 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.2 | 11.0 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 7.5 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.1 | 6.6 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.2 | 4.9 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 4.5 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 4.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 4.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 3.8 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 11.4 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.1 | 8.2 | REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 | Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1 |
| 0.6 | 6.6 | REACTOME ARMS MEDIATED ACTIVATION | Genes involved in ARMS-mediated activation |
| 0.1 | 5.0 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.1 | 4.7 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.2 | 4.5 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.2 | 4.5 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.1 | 4.4 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 4.2 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.2 | 3.3 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |