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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for UUGGCAA
Z-value: 0.22
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miRNA associated with seed UUGGCAA
| Name | miRBASE accession |
|---|---|
|
hsa-miR-182-5p
|
MIMAT0000259 |
Network of associatons between targets according to the STRING database.
First level regulatory network of UUGGCAA
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 9.4 | GO:0034356 | NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356) |
| 1.3 | 5.0 | GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity(GO:0042271) |
| 0.1 | 4.6 | GO:0032007 | negative regulation of TOR signaling(GO:0032007) |
| 0.3 | 4.5 | GO:0070831 | basement membrane assembly(GO:0070831) |
| 0.3 | 4.2 | GO:1900038 | negative regulation of cellular response to hypoxia(GO:1900038) |
| 0.1 | 4.2 | GO:0048286 | lung alveolus development(GO:0048286) |
| 0.4 | 4.1 | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387) |
| 0.3 | 4.1 | GO:0045116 | protein neddylation(GO:0045116) |
| 0.0 | 4.0 | GO:0006406 | mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427) |
| 0.1 | 3.9 | GO:0001953 | negative regulation of cell-matrix adhesion(GO:0001953) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 26.3 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 13.7 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.1 | 6.9 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.1 | 6.0 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.4 | 5.7 | GO:0030663 | COPI-coated vesicle membrane(GO:0030663) |
| 0.4 | 4.6 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.2 | 4.5 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.0 | 4.4 | GO:0043296 | apical junction complex(GO:0043296) |
| 0.0 | 4.2 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.2 | 4.0 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.0 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 7.3 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 6.4 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.1 | 6.4 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.1 | 5.6 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 5.6 | GO:0003924 | GTPase activity(GO:0003924) |
| 1.6 | 4.8 | GO:0004514 | nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514) |
| 1.2 | 4.6 | GO:0008112 | nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760) |
| 0.2 | 4.3 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.1 | 4.3 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.7 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 9.4 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 5.5 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.1 | 5.4 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.2 | 4.5 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 4.4 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 3.9 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 3.6 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 3.3 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.1 | 3.1 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 7.0 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.2 | 4.9 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.2 | 4.8 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 4.6 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.1 | 4.3 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.1 | 4.3 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 3.9 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 3.8 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.2 | 3.5 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |