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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for UUGGCAC
Z-value: 1.72
Motif logo
miRNA associated with seed UUGGCAC
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_20812690 Show fit | 41.70 |
ENST00000375078.3
|
calcium/calmodulin-dependent protein kinase II inhibitor 1 |
|
| chrX_-_13956737 Show fit | 40.53 |
ENST00000454189.2
|
glycoprotein M6B |
|
| chr4_-_176923483 Show fit | 37.50 |
ENST00000280187.7
ENST00000512509.1 |
glycoprotein M6A |
|
| chr8_+_80523321 Show fit | 31.65 |
ENST00000518111.1
|
stathmin-like 2 |
|
| chr16_+_8768422 Show fit | 30.71 |
ENST00000268251.8
ENST00000564714.1 |
4-aminobutyrate aminotransferase |
|
| chr2_+_203499901 Show fit | 24.28 |
ENST00000303116.6
ENST00000392238.2 |
family with sequence similarity 117, member B |
|
| chr3_+_115342159 Show fit | 24.13 |
ENST00000305124.6
|
growth associated protein 43 |
|
| chr1_+_151043070 Show fit | 24.04 |
ENST00000368918.3
ENST00000368917.1 |
GA binding protein transcription factor, beta subunit 2 |
|
| chr14_-_74551172 Show fit | 21.33 |
ENST00000553458.1
|
aldehyde dehydrogenase 6 family, member A1 |
|
| chr2_+_113033164 Show fit | 20.73 |
ENST00000409871.1
ENST00000343936.4 |
zinc finger CCCH-type containing 6 |
Network of associatons between targets according to the STRING database.
First level regulatory network of UUGGCAC
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 40.5 | GO:0051610 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.8 | 34.1 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.9 | 33.6 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 7.9 | 31.7 | GO:0031117 | positive regulation of microtubule depolymerization(GO:0031117) |
| 7.7 | 30.7 | GO:1904450 | negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450) |
| 2.4 | 24.1 | GO:0016198 | axon choice point recognition(GO:0016198) |
| 1.7 | 21.5 | GO:0048227 | plasma membrane to endosome transport(GO:0048227) |
| 0.1 | 21.5 | GO:0051260 | protein homooligomerization(GO:0051260) |
| 5.3 | 21.3 | GO:0006210 | pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859) |
| 0.2 | 20.2 | GO:1990823 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 69.2 | GO:0030426 | growth cone(GO:0030426) |
| 2.5 | 50.1 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.3 | 41.2 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.2 | 37.4 | GO:0099572 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.8 | 37.2 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.4 | 37.2 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 7.7 | 30.7 | GO:0032144 | 4-aminobutyrate transaminase complex(GO:0032144) |
| 0.5 | 28.2 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.3 | 28.2 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 1.5 | 25.3 | GO:0033270 | paranode region of axon(GO:0033270) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 44.5 | GO:0005262 | calcium channel activity(GO:0005262) |
| 6.9 | 41.7 | GO:0010858 | calcium-dependent protein kinase regulator activity(GO:0010858) |
| 0.1 | 35.8 | GO:0005509 | calcium ion binding(GO:0005509) |
| 7.7 | 30.7 | GO:0032145 | 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298) |
| 1.2 | 28.4 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 1.3 | 27.8 | GO:1905030 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.8 | 26.3 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 2.4 | 24.1 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
| 0.3 | 23.6 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.9 | 21.3 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 32.7 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.6 | 25.9 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.4 | 24.3 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.2 | 24.2 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 19.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 18.7 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 15.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 14.3 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.4 | 13.6 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.6 | 13.3 | PID EPHB FWD PATHWAY | EPHB forward signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 30.7 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.7 | 28.4 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.5 | 21.2 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.8 | 20.9 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.8 | 19.9 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.6 | 19.8 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.6 | 18.2 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.4 | 17.7 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.3 | 17.7 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 17.1 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |