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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for UUUUUGC

Z-value: 0.08

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miRNA associated with seed UUUUUGC

NamemiRBASE accession
hsa-miR-129-5p
MIMAT0000242

Activity profile of UUUUUGC motif

Sorted Z-values of UUUUUGC motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_20812690 1.00 ENST00000375078.3
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr14_-_51562745 0.17 ENST00000298355.3
TRIM9
tripartite motif containing 9
chr4_-_153457197 0.16 ENST00000281708.4
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr22_+_40390930 0.12 ENST00000333407.6
FAM83F
family with sequence similarity 83, member F
chr17_-_27278304 0.11 ENST00000577226.1
PHF12
PHD finger protein 12
chr5_-_78809950 0.11 ENST00000334082.6
HOMER1
homer homolog 1 (Drosophila)
chr13_+_58206655 0.10 ENST00000377918.3
PCDH17
protocadherin 17
chr9_-_14314066 0.10 ENST00000397575.3
NFIB
nuclear factor I/B
chr8_+_42752053 0.10 ENST00000307602.4
HOOK3
hook microtubule-tethering protein 3
chr3_+_181429704 0.06 ENST00000431565.2
ENST00000325404.1
SOX2
SRY (sex determining region Y)-box 2
chr2_-_152955537 0.06 ENST00000201943.5
ENST00000539935.1
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr8_-_93115445 0.05 ENST00000523629.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr21_-_39288743 0.05 ENST00000609713.1
KCNJ6
potassium inwardly-rectifying channel, subfamily J, member 6
chr4_-_170924888 0.05 ENST00000502832.1
ENST00000393704.3
MFAP3L
microfibrillar-associated protein 3-like
chr5_+_125935960 0.05 ENST00000297540.4
PHAX
phosphorylated adaptor for RNA export
chr2_+_168725458 0.05 ENST00000392690.3
B3GALT1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr13_-_107187462 0.04 ENST00000245323.4
EFNB2
ephrin-B2
chr5_-_132948216 0.04 ENST00000265342.7
FSTL4
follistatin-like 4
chr8_+_12803176 0.03 ENST00000524591.2
KIAA1456
KIAA1456
chr10_+_111967345 0.03 ENST00000332674.5
ENST00000453116.1
MXI1
MAX interactor 1, dimerization protein
chrX_+_119384607 0.03 ENST00000326624.2
ENST00000557385.1
ZBTB33
zinc finger and BTB domain containing 33
chr6_-_90121938 0.03 ENST00000369415.4
RRAGD
Ras-related GTP binding D
chr3_+_142720366 0.02 ENST00000493782.1
ENST00000397933.2
ENST00000473835.2
ENST00000493598.2
U2SURP
U2 snRNP-associated SURP domain containing
chr12_+_51985001 0.01 ENST00000354534.6
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr7_-_92463210 0.01 ENST00000265734.4
CDK6
cyclin-dependent kinase 6
chr12_+_2162447 0.01 ENST00000335762.5
ENST00000399655.1
CACNA1C
calcium channel, voltage-dependent, L type, alpha 1C subunit

Network of associatons between targets according to the STRING database.

First level regulatory network of UUUUUGC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.0 0.1 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.0 0.2 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.0 0.1 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.1 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)
0.0 0.1 GO:0021730 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 0.0 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.0 0.0 GO:0006408 snRNA export from nucleus(GO:0006408)
0.0 0.1 GO:0001714 endodermal cell fate specification(GO:0001714)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0070695 FHF complex(GO:0070695)
0.0 0.2 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.0 0.2 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.0 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)