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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for VAX1_GSX2
Z-value: 0.21
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Transcription factors associated with VAX1_GSX2
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_+_111718036 Show fit | 8.54 |
ENST00000455401.2
|
transgelin 3 |
|
| chr3_+_111717600 Show fit | 8.47 |
ENST00000273368.4
|
transgelin 3 |
|
| chr3_+_111717511 Show fit | 8.26 |
ENST00000478951.1
ENST00000393917.2 |
transgelin 3 |
|
| chr3_+_111718173 Show fit | 7.95 |
ENST00000494932.1
|
transgelin 3 |
|
| chr7_+_100770328 Show fit | 6.96 |
ENST00000223095.4
ENST00000445463.2 |
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
|
| chr9_+_125132803 Show fit | 6.28 |
ENST00000540753.1
|
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) |
|
| chr11_-_129062093 Show fit | 4.37 |
ENST00000310343.9
|
Rho GTPase activating protein 32 |
|
| chr10_-_5046042 Show fit | 3.30 |
ENST00000421196.3
ENST00000455190.1 |
aldo-keto reductase family 1, member C2 |
|
| chr15_+_84115868 Show fit | 2.85 |
ENST00000427482.2
|
SH3-domain GRB2-like 3 |
|
| chr18_+_46065393 Show fit | 2.82 |
ENST00000256413.3
|
CBP80/20-dependent translation initiation factor |
Network of associatons between targets according to the STRING database.
First level regulatory network of VAX1_GSX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 34.8 | GO:0007417 | central nervous system development(GO:0007417) |
| 0.5 | 8.3 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 2.3 | 7.0 | GO:2000097 | chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.0 | 6.5 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 0.9 | 6.1 | GO:0071395 | response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395) |
| 0.1 | 4.8 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.1 | 4.6 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
| 0.5 | 4.2 | GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665) |
| 0.4 | 3.9 | GO:0051552 | flavone metabolic process(GO:0051552) |
| 1.2 | 3.7 | GO:0061357 | positive regulation of Wnt protein secretion(GO:0061357) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 33.3 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.1 | 14.3 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 7.4 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.1 | 3.7 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 3.0 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) |
| 0.0 | 3.0 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 2.7 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 2.5 | GO:0016591 | DNA-directed RNA polymerase II, holoenzyme(GO:0016591) |
| 0.0 | 2.2 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.1 | 2.1 | GO:0042627 | chylomicron(GO:0042627) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 35.2 | GO:0051015 | actin filament binding(GO:0051015) |
| 2.1 | 8.3 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
| 0.1 | 8.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 1.0 | 6.1 | GO:0047086 | phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086) trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115) |
| 0.0 | 5.3 | GO:0035091 | phosphatidylinositol binding(GO:0035091) |
| 0.1 | 5.0 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.6 | 4.8 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.1 | 4.7 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.2 | 4.6 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.1 | 4.5 | GO:0001972 | retinoic acid binding(GO:0001972) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.9 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 7.8 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 6.0 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 5.3 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 4.5 | ST ADRENERGIC | Adrenergic Pathway |
| 0.1 | 2.2 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 1.9 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.8 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.0 | 1.6 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 1.5 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.3 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.1 | 7.0 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 5.3 | REACTOME SIGNALING BY PDGF | Genes involved in Signaling by PDGF |
| 0.3 | 4.8 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.2 | 4.2 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 3.0 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.1 | 2.9 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.0 | 2.8 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.0 | 2.7 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 2.5 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |