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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for VAX2_RHOXF2

Z-value: 1.28

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Transcription factors associated with VAX2_RHOXF2

Gene Symbol Gene ID Gene Info
VAX2
ENSG00000116035.2 ventral anterior homeobox 2
RHOXF2
ENSG00000131721.4 Rhox homeobox family member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
VAX2hg19_v2_chr2_+_71127699_711277440.412.1e-10Click!

Activity profile of VAX2_RHOXF2 motif

Sorted Z-values of VAX2_RHOXF2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_57045228 15.68 ENST00000371250.3
PPAP2B
phosphatidic acid phosphatase type 2B
chr12_-_6233828 11.91 ENST00000572068.1
ENST00000261405.5
VWF
von Willebrand factor
chr2_+_90248739 11.02 ENST00000468879.1
IGKV1D-43
immunoglobulin kappa variable 1D-43
chr2_-_89340242 9.97 ENST00000480492.1
IGKV1-12
immunoglobulin kappa variable 1-12
chr5_+_66300446 9.82 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr11_-_117747607 9.63 ENST00000540359.1
ENST00000539526.1
FXYD6
FXYD domain containing ion transport regulator 6
chr11_-_117747434 9.58 ENST00000529335.2
ENST00000530956.1
ENST00000260282.4
FXYD6
FXYD domain containing ion transport regulator 6
chr11_-_117748138 8.61 ENST00000527717.1
FXYD6
FXYD domain containing ion transport regulator 6
chr11_-_111794446 7.35 ENST00000527950.1
CRYAB
crystallin, alpha B
chr17_-_41466555 6.96 ENST00000586231.1
LINC00910
long intergenic non-protein coding RNA 910
chr4_-_186696425 6.71 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
SORBS2
sorbin and SH3 domain containing 2
chr12_+_26348246 5.32 ENST00000422622.2
SSPN
sarcospan
chr3_-_112127981 4.71 ENST00000486726.2
RP11-231E6.1
RP11-231E6.1
chr2_-_89292422 4.42 ENST00000495489.1
IGKV1-8
immunoglobulin kappa variable 1-8
chr1_-_211307404 4.37 ENST00000367007.4
KCNH1
potassium voltage-gated channel, subfamily H (eag-related), member 1
chr6_+_26402517 4.06 ENST00000414912.2
BTN3A1
butyrophilin, subfamily 3, member A1
chr16_-_55866997 3.51 ENST00000360526.3
ENST00000361503.4
CES1
carboxylesterase 1
chr11_+_71900572 3.38 ENST00000312293.4
FOLR1
folate receptor 1 (adult)
chr19_+_50016610 3.27 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr14_-_53258314 3.21 ENST00000216410.3
ENST00000557604.1
GNPNAT1
glucosamine-phosphate N-acetyltransferase 1
chr6_+_26402465 3.13 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
BTN3A1
butyrophilin, subfamily 3, member A1
chr11_+_71900703 3.10 ENST00000393681.2
FOLR1
folate receptor 1 (adult)
chrX_+_43515467 2.99 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr9_+_131062367 2.95 ENST00000601297.1
AL359091.2
CDNA: FLJ21673 fis, clone COL09042; HCG2036511; Uncharacterized protein
chr20_+_56136136 2.72 ENST00000319441.4
ENST00000543666.1
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr1_+_35258592 2.62 ENST00000342280.4
ENST00000450137.1
GJA4
gap junction protein, alpha 4, 37kDa
chr9_-_95166841 2.43 ENST00000262551.4
OGN
osteoglycin
chr17_+_40610862 2.42 ENST00000393829.2
ENST00000546249.1
ENST00000537728.1
ENST00000264649.6
ENST00000585525.1
ENST00000343619.4
ENST00000544137.1
ENST00000589727.1
ENST00000587824.1
ATP6V0A1
ATPase, H+ transporting, lysosomal V0 subunit a1
chr2_+_113763031 2.36 ENST00000259211.6
IL36A
interleukin 36, alpha
chr12_-_118796910 2.31 ENST00000541186.1
ENST00000539872.1
TAOK3
TAO kinase 3
chr3_+_115342349 2.05 ENST00000393780.3
GAP43
growth associated protein 43
chr4_+_88571429 1.97 ENST00000339673.6
ENST00000282479.7
DMP1
dentin matrix acidic phosphoprotein 1
chr1_+_62439037 1.94 ENST00000545929.1
INADL
InaD-like (Drosophila)
chr4_+_88754113 1.89 ENST00000560249.1
ENST00000540395.1
ENST00000511670.1
ENST00000361056.3
MEPE
matrix extracellular phosphoglycoprotein
chr10_-_17171817 1.87 ENST00000377833.4
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr7_+_50348268 1.83 ENST00000438033.1
ENST00000439701.1
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr16_+_72088376 1.80 ENST00000570083.1
ENST00000355906.5
ENST00000398131.2
ENST00000569639.1
ENST00000564499.1
ENST00000357763.4
ENST00000562526.1
ENST00000565574.1
ENST00000568417.2
ENST00000356967.5
HP
HPR
haptoglobin
haptoglobin-related protein
chr1_-_92952433 1.80 ENST00000294702.5
GFI1
growth factor independent 1 transcription repressor
chr12_+_26348429 1.80 ENST00000242729.2
SSPN
sarcospan
chr4_+_80584903 1.68 ENST00000506460.1
RP11-452C8.1
RP11-452C8.1
chr1_-_24151903 1.66 ENST00000436439.2
ENST00000374490.3
HMGCL
3-hydroxymethyl-3-methylglutaryl-CoA lyase
chr12_+_81110684 1.65 ENST00000228644.3
MYF5
myogenic factor 5
chr2_+_169926047 1.62 ENST00000428522.1
ENST00000450153.1
ENST00000421653.1
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr6_+_26440700 1.57 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
BTN3A3
butyrophilin, subfamily 3, member A3
chr2_-_89597542 1.55 ENST00000465170.1
IGKV1-37
immunoglobulin kappa variable 1-37 (non-functional)
chr5_-_20575959 1.51 ENST00000507958.1
CDH18
cadherin 18, type 2
chrX_+_135730373 1.47 ENST00000370628.2
CD40LG
CD40 ligand
chr5_+_129083772 1.45 ENST00000564719.1
KIAA1024L
KIAA1024-like
chr9_-_5339873 1.40 ENST00000223862.1
ENST00000223858.4
RLN1
relaxin 1
chr12_-_10022735 1.38 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr11_-_62521614 1.38 ENST00000527994.1
ENST00000394807.3
ZBTB3
zinc finger and BTB domain containing 3
chrX_+_153533275 1.36 ENST00000426989.1
ENST00000426203.1
ENST00000369912.2
TKTL1
transketolase-like 1
chr12_-_9760482 1.36 ENST00000229402.3
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chr1_+_46972668 1.32 ENST00000371956.4
ENST00000360032.3
DMBX1
diencephalon/mesencephalon homeobox 1
chr14_+_103851712 1.31 ENST00000440884.3
ENST00000416682.2
ENST00000429436.2
ENST00000303622.9
MARK3
MAP/microtubule affinity-regulating kinase 3
chr15_+_58702742 1.29 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr17_-_40337470 1.24 ENST00000293330.1
HCRT
hypocretin (orexin) neuropeptide precursor
chr7_-_100860851 1.17 ENST00000223127.3
PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr3_+_152552685 1.13 ENST00000305097.3
P2RY1
purinergic receptor P2Y, G-protein coupled, 1
chr9_-_5304432 1.05 ENST00000416837.1
ENST00000308420.3
RLN2
relaxin 2
chr17_-_18430160 0.97 ENST00000392176.3
FAM106A
family with sequence similarity 106, member A
chr16_-_28608424 0.95 ENST00000335715.4
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr21_-_37914898 0.93 ENST00000399136.1
CLDN14
claudin 14
chr12_-_22063787 0.89 ENST00000544039.1
ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chrX_+_135730297 0.82 ENST00000370629.2
CD40LG
CD40 ligand
chr10_+_18549645 0.78 ENST00000396576.2
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr14_+_32798547 0.75 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr11_+_33061543 0.74 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
TCP11L1
t-complex 11, testis-specific-like 1
chr1_+_153747746 0.72 ENST00000368661.3
SLC27A3
solute carrier family 27 (fatty acid transporter), member 3
chr9_-_95166884 0.71 ENST00000375561.5
OGN
osteoglycin
chr4_+_169418255 0.70 ENST00000505667.1
ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr6_-_133035185 0.69 ENST00000367928.4
VNN1
vanin 1
chr18_-_67624160 0.66 ENST00000581982.1
ENST00000280200.4
CD226
CD226 molecule
chr2_+_103089756 0.65 ENST00000295269.4
SLC9A4
solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4
chr2_-_214016314 0.64 ENST00000434687.1
ENST00000374319.4
IKZF2
IKAROS family zinc finger 2 (Helios)
chr14_+_32798462 0.61 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr14_-_20923195 0.61 ENST00000206542.4
OSGEP
O-sialoglycoprotein endopeptidase
chr19_+_12175504 0.59 ENST00000439326.3
ZNF844
zinc finger protein 844
chr7_-_44580861 0.57 ENST00000546276.1
ENST00000289547.4
ENST00000381160.3
ENST00000423141.1
NPC1L1
NPC1-like 1
chr4_-_74486347 0.56 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr5_+_140557371 0.51 ENST00000239444.2
PCDHB8
protocadherin beta 8
chr17_-_10372875 0.47 ENST00000255381.2
MYH4
myosin, heavy chain 4, skeletal muscle
chr14_+_72399833 0.46 ENST00000553530.1
ENST00000556437.1
RGS6
regulator of G-protein signaling 6
chr9_-_21239978 0.41 ENST00000380222.2
IFNA14
interferon, alpha 14
chr16_-_28608364 0.38 ENST00000533150.1
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr13_-_36050819 0.37 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr5_+_174151536 0.35 ENST00000239243.6
ENST00000507785.1
MSX2
msh homeobox 2
chr15_-_89755034 0.33 ENST00000563254.1
RLBP1
retinaldehyde binding protein 1
chr1_+_225600404 0.31 ENST00000366845.2
AC092811.1
AC092811.1
chr20_-_50722183 0.31 ENST00000371523.4
ZFP64
ZFP64 zinc finger protein
chr6_+_167536230 0.29 ENST00000341935.5
ENST00000349984.4
CCR6
chemokine (C-C motif) receptor 6
chr7_+_73245193 0.27 ENST00000340958.2
CLDN4
claudin 4
chr1_-_152386732 0.26 ENST00000271835.3
CRNN
cornulin
chr16_-_30122717 0.24 ENST00000566613.1
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chrX_-_18690210 0.21 ENST00000379984.3
RS1
retinoschisin 1
chr19_-_46088068 0.16 ENST00000263275.4
ENST00000323060.3
OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr4_-_74486217 0.15 ENST00000335049.5
ENST00000307439.5
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr5_-_149829244 0.13 ENST00000312037.5
RPS14
ribosomal protein S14
chr7_+_148936732 0.09 ENST00000335870.2
ZNF212
zinc finger protein 212
chr2_-_85555385 0.07 ENST00000377386.3
TGOLN2
trans-golgi network protein 2
chr4_+_70796784 0.06 ENST00000246891.4
ENST00000444405.3
CSN1S1
casein alpha s1
chr11_-_102709441 0.05 ENST00000434103.1
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr14_+_74034310 0.03 ENST00000538782.1
ACOT2
acyl-CoA thioesterase 2

Network of associatons between targets according to the STRING database.

First level regulatory network of VAX2_RHOXF2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.5 GO:0061713 neural crest cell migration involved in heart formation(GO:0003147) cell migration involved in heart formation(GO:0060974) anterior neural tube closure(GO:0061713)
0.7 2.7 GO:0006114 glycerol biosynthetic process(GO:0006114) response to methionine(GO:1904640)
0.6 3.2 GO:0006041 glucosamine metabolic process(GO:0006041)
0.6 4.4 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.6 1.8 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.6 1.8 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.5 11.9 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.5 3.3 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.4 7.4 GO:0007021 tubulin complex assembly(GO:0007021)
0.4 1.2 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.4 27.8 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.4 3.5 GO:0051791 medium-chain fatty acid metabolic process(GO:0051791)
0.3 1.4 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.3 6.5 GO:0072643 interferon-gamma secretion(GO:0072643)
0.3 2.3 GO:0070166 enamel mineralization(GO:0070166)
0.2 1.1 GO:0060406 positive regulation of penile erection(GO:0060406)
0.2 0.7 GO:0060369 natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.2 6.7 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.2 1.2 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.2 2.0 GO:0016198 axon choice point recognition(GO:0016198)
0.2 0.6 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.2 2.4 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.2 1.4 GO:0006772 thiamine metabolic process(GO:0006772)
0.2 1.3 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.2 3.0 GO:0042420 dopamine catabolic process(GO:0042420)
0.2 1.9 GO:0015889 cobalamin transport(GO:0015889)
0.2 1.7 GO:0006552 leucine catabolic process(GO:0006552)
0.2 3.1 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.2 0.8 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.2 1.7 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.1 1.6 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1 1.3 GO:0008343 adult feeding behavior(GO:0008343)
0.1 23.1 GO:0002377 immunoglobulin production(GO:0002377)
0.1 1.3 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372) phosphatidylcholine catabolic process(GO:0034638)
0.1 0.7 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.1 1.9 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.1 2.6 GO:0048265 response to pain(GO:0048265)
0.1 1.3 GO:0006068 ethanol catabolic process(GO:0006068)
0.1 0.6 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.3 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 1.2 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.6 GO:0098856 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.0 2.4 GO:0032755 positive regulation of interleukin-6 production(GO:0032755)
0.0 0.6 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 10.2 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.9 GO:0010107 potassium ion import(GO:0010107)
0.0 0.2 GO:0009642 response to light intensity(GO:0009642)
0.0 1.6 GO:0002456 T cell mediated immunity(GO:0002456)
0.0 7.6 GO:0006936 muscle contraction(GO:0006936)
0.0 1.8 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 2.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.0 GO:0030819 positive regulation of cAMP biosynthetic process(GO:0030819)
0.0 3.9 GO:0002250 adaptive immune response(GO:0002250)
0.0 0.1 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 11.9 GO:0033093 Weibel-Palade body(GO:0033093)
0.5 7.4 GO:0097512 cardiac myofibril(GO:0097512)
0.5 1.8 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.4 6.5 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.3 1.9 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.3 0.9 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.3 2.0 GO:0032584 growth cone membrane(GO:0032584)
0.3 2.4 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.2 7.1 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.2 1.4 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1 2.6 GO:0005922 connexon complex(GO:0005922)
0.1 1.8 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 0.6 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.1 4.4 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 0.8 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 1.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.2 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 6.8 GO:0030018 Z disc(GO:0030018)
0.0 0.6 GO:0031526 brush border membrane(GO:0031526)
0.0 0.5 GO:0032982 myosin filament(GO:0032982)
0.0 1.3 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 3.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.3 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 3.2 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 5.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 3.0 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.7 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 20.6 GO:0005615 extracellular space(GO:0005615)
0.0 1.6 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 1.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 18.6 GO:0005887 integral component of plasma membrane(GO:0005887)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.5 GO:0061714 folic acid receptor activity(GO:0061714)
0.9 2.7 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.8 3.3 GO:0019770 IgG receptor activity(GO:0019770)
0.8 2.3 GO:0005174 CD40 receptor binding(GO:0005174)
0.7 4.4 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.7 3.5 GO:0004771 sterol esterase activity(GO:0004771) methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.6 1.7 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.5 27.8 GO:0017080 sodium channel regulator activity(GO:0017080)
0.5 1.4 GO:0004802 transketolase activity(GO:0004802)
0.4 11.9 GO:0019865 immunoglobulin binding(GO:0019865)
0.4 1.2 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823) procollagen galactosyltransferase activity(GO:0050211)
0.4 1.9 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.4 3.0 GO:0008131 primary amine oxidase activity(GO:0008131)
0.3 1.8 GO:0030492 hemoglobin binding(GO:0030492)
0.3 1.1 GO:0031685 adenosine receptor binding(GO:0031685)
0.2 6.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 7.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.2 2.0 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.2 1.3 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.2 1.9 GO:0031419 cobalamin binding(GO:0031419)
0.2 1.6 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.1 0.7 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.1 2.4 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 25.4 GO:0003823 antigen binding(GO:0003823)
0.1 0.8 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.1 2.4 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 1.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 0.3 GO:0005502 11-cis retinal binding(GO:0005502)
0.1 0.9 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.1 1.3 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 0.6 GO:0015386 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.1 0.7 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 1.2 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 3.2 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.0 1.7 GO:0070888 E-box binding(GO:0070888)
0.0 0.3 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.3 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.6 GO:0031489 myosin V binding(GO:0031489)
0.0 1.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.2 GO:0070492 phosphatidylinositol-5-phosphate binding(GO:0010314) oligosaccharide binding(GO:0070492)
0.0 1.9 GO:0005179 hormone activity(GO:0005179)
0.0 11.7 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 3.1 GO:0008083 growth factor activity(GO:0008083)
0.0 0.5 GO:0000146 microfilament motor activity(GO:0000146)
0.0 3.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.5 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 15.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 2.3 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 2.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.8 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.6 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.8 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 11.9 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.5 15.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.2 2.7 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.2 3.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.2 3.0 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.2 3.1 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 2.6 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 4.4 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 3.1 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 3.2 REACTOME LIPOPROTEIN METABOLISM Genes involved in Lipoprotein metabolism
0.1 1.1 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 1.3 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.5 REACTOME CELL CELL JUNCTION ORGANIZATION Genes involved in Cell-cell junction organization
0.0 1.7 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 3.0 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.3 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.9 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.8 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 1.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.3 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling