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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for VAX2_RHOXF2
Z-value: 1.28
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Transcription factors associated with VAX2_RHOXF2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| VAX2 | hg19_v2_chr2_+_71127699_71127744 | 0.41 | 2.1e-10 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_57045228 Show fit | 15.68 |
ENST00000371250.3
|
phosphatidic acid phosphatase type 2B |
|
| chr12_-_6233828 Show fit | 11.91 |
ENST00000572068.1
ENST00000261405.5 |
von Willebrand factor |
|
| chr2_+_90248739 Show fit | 11.02 |
ENST00000468879.1
|
immunoglobulin kappa variable 1D-43 |
|
| chr2_-_89340242 Show fit | 9.97 |
ENST00000480492.1
|
immunoglobulin kappa variable 1-12 |
|
| chr5_+_66300446 Show fit | 9.82 |
ENST00000261569.7
|
microtubule associated serine/threonine kinase family member 4 |
|
| chr11_-_117747607 Show fit | 9.63 |
ENST00000540359.1
ENST00000539526.1 |
FXYD domain containing ion transport regulator 6 |
|
| chr11_-_117747434 Show fit | 9.58 |
ENST00000529335.2
ENST00000530956.1 ENST00000260282.4 |
FXYD domain containing ion transport regulator 6 |
|
| chr11_-_117748138 Show fit | 8.61 |
ENST00000527717.1
|
FXYD domain containing ion transport regulator 6 |
|
| chr11_-_111794446 Show fit | 7.35 |
ENST00000527950.1
|
crystallin, alpha B |
|
| chr17_-_41466555 Show fit | 6.96 |
ENST00000586231.1
|
long intergenic non-protein coding RNA 910 |
Network of associatons between targets according to the STRING database.
First level regulatory network of VAX2_RHOXF2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 27.8 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 0.1 | 23.1 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.5 | 11.9 | GO:0007597 | blood coagulation, intrinsic pathway(GO:0007597) |
| 0.0 | 10.2 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 0.0 | 7.6 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.4 | 7.4 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.2 | 6.7 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 2.2 | 6.5 | GO:0061713 | neural crest cell migration involved in heart formation(GO:0003147) cell migration involved in heart formation(GO:0060974) anterior neural tube closure(GO:0061713) |
| 0.3 | 6.5 | GO:0072643 | interferon-gamma secretion(GO:0072643) |
| 0.6 | 4.4 | GO:0000160 | phosphorelay signal transduction system(GO:0000160) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 20.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 18.6 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 1.0 | 11.9 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.5 | 7.4 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.2 | 7.1 | GO:0090665 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 6.8 | GO:0030018 | Z disc(GO:0030018) |
| 0.4 | 6.5 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.0 | 5.4 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 4.4 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 3.2 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 27.8 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 25.4 | GO:0003823 | antigen binding(GO:0003823) |
| 0.4 | 11.9 | GO:0019865 | immunoglobulin binding(GO:0019865) |
| 0.0 | 11.7 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.2 | 7.4 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.2 | 6.7 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 1.6 | 6.5 | GO:0061714 | folic acid receptor activity(GO:0061714) |
| 0.7 | 4.4 | GO:0000155 | phosphorelay sensor kinase activity(GO:0000155) |
| 0.7 | 3.5 | GO:0004771 | sterol esterase activity(GO:0004771) methylumbelliferyl-acetate deacetylase activity(GO:0047374) |
| 0.0 | 3.5 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 3.5 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.1 | 3.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 2.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 2.3 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 1.8 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 1.8 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 0.6 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 15.7 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.7 | 11.9 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.1 | 4.4 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.2 | 3.2 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.1 | 3.2 | REACTOME LIPOPROTEIN METABOLISM | Genes involved in Lipoprotein metabolism |
| 0.2 | 3.1 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.1 | 3.1 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 3.0 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 3.0 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.2 | 2.7 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |