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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for VENTX
Z-value: 0.12
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Transcription factors associated with VENTX
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| VENTX | hg19_v2_chr10_+_135050908_135050908 | 0.13 | 5.4e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of VENTX
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 22.2 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 0.2 | 19.6 | GO:0006903 | vesicle targeting(GO:0006903) |
| 1.1 | 7.5 | GO:1901315 | negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915) |
| 0.0 | 5.5 | GO:0007018 | microtubule-based movement(GO:0007018) |
| 0.2 | 5.2 | GO:0000042 | protein targeting to Golgi(GO:0000042) |
| 0.0 | 4.4 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 0.7 | 3.6 | GO:2000382 | positive regulation of mesoderm development(GO:2000382) |
| 1.0 | 2.9 | GO:0038188 | cholecystokinin signaling pathway(GO:0038188) |
| 0.0 | 2.6 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.2 | 2.3 | GO:0048742 | regulation of skeletal muscle fiber development(GO:0048742) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.8 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.3 | 19.6 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.4 | 5.5 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.0 | 4.5 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 4.2 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.1 | 2.0 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.2 | 1.9 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.1 | 1.9 | GO:0030897 | HOPS complex(GO:0030897) |
| 0.0 | 1.7 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 1.6 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 24.4 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.5 | 7.5 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.1 | 5.5 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.3 | 4.3 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 3.6 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 1.0 | 2.9 | GO:0004951 | cholecystokinin receptor activity(GO:0004951) |
| 0.0 | 2.6 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.2 | 2.4 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.0 | 2.2 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.1 | 1.9 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.8 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 2.0 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.6 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 1.6 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.4 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 1.3 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.1 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.9 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.8 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 0.8 | PID ILK PATHWAY | Integrin-linked kinase signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.8 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 3.8 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.1 | 1.7 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 | Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) |
| 0.0 | 1.4 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 0.9 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.0 | 0.8 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 0.0 | 0.8 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 0.6 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.0 | 0.5 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 0.4 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |