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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for VSX1
Z-value: 1.16
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Transcription factors associated with VSX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| VSX1 | hg19_v2_chr20_-_25062767_25062779 | -0.37 | 1.5e-08 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of VSX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.9 | 65.4 | GO:0046985 | positive regulation of hemoglobin biosynthetic process(GO:0046985) |
| 1.1 | 55.2 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 1.1 | 49.4 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 11.9 | 47.7 | GO:0019747 | regulation of isoprenoid metabolic process(GO:0019747) |
| 15.1 | 45.3 | GO:0006435 | threonyl-tRNA aminoacylation(GO:0006435) |
| 0.5 | 44.0 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 5.3 | 42.0 | GO:0010994 | regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) positive regulation of exit from mitosis(GO:0031536) |
| 1.0 | 41.8 | GO:0006294 | nucleotide-excision repair, preincision complex assembly(GO:0006294) |
| 3.8 | 38.2 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 3.9 | 35.3 | GO:0061732 | mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.4 | 114.9 | GO:0034709 | methylosome(GO:0034709) |
| 1.0 | 55.2 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.5 | 52.3 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.5 | 49.0 | GO:0043657 | host(GO:0018995) host cell(GO:0043657) |
| 1.4 | 42.6 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 1.0 | 38.9 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 1.0 | 38.2 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 1.8 | 34.7 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 4.1 | 32.7 | GO:0042382 | paraspeckles(GO:0042382) |
| 3.0 | 29.8 | GO:0070938 | contractile ring(GO:0070938) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.9 | 65.4 | GO:0044020 | histone methyltransferase activity (H4-R3 specific)(GO:0044020) |
| 7.9 | 55.2 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 1.2 | 55.2 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.2 | 50.8 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.9 | 49.2 | GO:0015485 | cholesterol binding(GO:0015485) |
| 15.1 | 45.3 | GO:0004829 | threonine-tRNA ligase activity(GO:0004829) |
| 2.1 | 43.9 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.9 | 42.0 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.4 | 41.2 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 0.2 | 38.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 60.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.8 | 47.7 | PID ATR PATHWAY | ATR signaling pathway |
| 0.6 | 45.7 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 1.0 | 25.3 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.4 | 22.9 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.4 | 22.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.3 | 14.1 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.3 | 13.5 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.3 | 13.3 | PID MYC PATHWAY | C-MYC pathway |
| 0.2 | 12.5 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 80.2 | REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 | Genes involved in SCF(Skp2)-mediated degradation of p27/p21 |
| 1.6 | 55.8 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.7 | 53.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 1.5 | 42.6 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 2.4 | 38.2 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.6 | 35.6 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.9 | 35.5 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 2.1 | 33.7 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.4 | 31.6 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.3 | 28.8 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |