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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for XBP1
Z-value: 0.66
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Transcription factors associated with XBP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| XBP1 | hg19_v2_chr22_-_29196546_29196585 | 0.40 | 7.0e-10 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of XBP1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 16.1 | 177.1 | GO:0031584 | activation of phospholipase D activity(GO:0031584) apical protein localization(GO:0045176) |
| 8.0 | 88.5 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 3.6 | 72.5 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.2 | 72.5 | GO:0043687 | post-translational protein modification(GO:0043687) |
| 0.8 | 69.8 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 11.1 | 66.7 | GO:0030581 | intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708) |
| 0.8 | 66.3 | GO:0036498 | IRE1-mediated unfolded protein response(GO:0036498) |
| 12.3 | 61.5 | GO:0006620 | posttranslational protein targeting to membrane(GO:0006620) |
| 4.4 | 57.4 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 0.3 | 56.7 | GO:0008213 | protein methylation(GO:0006479) protein alkylation(GO:0008213) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 187.4 | GO:0032587 | ruffle membrane(GO:0032587) |
| 8.3 | 83.5 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.8 | 82.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.3 | 71.1 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 6.2 | 68.3 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 16.7 | 66.7 | GO:0036502 | Derlin-1-VIMP complex(GO:0036502) |
| 1.8 | 66.4 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 8.1 | 56.7 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
| 1.0 | 53.4 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 10.3 | 51.7 | GO:0044352 | pinosome(GO:0044352) macropinosome(GO:0044354) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.3 | 190.7 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.1 | 112.2 | GO:0003723 | RNA binding(GO:0003723) |
| 0.1 | 104.6 | GO:0005509 | calcium ion binding(GO:0005509) |
| 19.1 | 76.2 | GO:0005046 | KDEL sequence binding(GO:0005046) |
| 0.4 | 76.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 3.7 | 66.7 | GO:1990381 | ubiquitin-specific protease binding(GO:1990381) |
| 19.1 | 57.4 | GO:0003974 | UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978) |
| 0.6 | 56.7 | GO:0008276 | protein methyltransferase activity(GO:0008276) |
| 0.1 | 56.1 | GO:0045296 | cadherin binding(GO:0045296) |
| 8.6 | 51.7 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 168.7 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.3 | 50.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.6 | 40.5 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.8 | 39.4 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.8 | 38.0 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.3 | 31.5 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 1.5 | 27.5 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.5 | 24.1 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.6 | 23.4 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.4 | 22.6 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 205.5 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 1.8 | 129.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.7 | 100.0 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 2.4 | 80.4 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 5.6 | 55.6 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.8 | 50.3 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 2.3 | 39.4 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.9 | 38.0 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 1.6 | 36.8 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.1 | 30.5 | REACTOME METABOLISM OF CARBOHYDRATES | Genes involved in Metabolism of carbohydrates |