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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ZBTB12
Z-value: 0.89
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Transcription factors associated with ZBTB12
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_158979792 Show fit | 20.08 |
ENST00000359709.3
ENST00000430894.2 |
interferon, gamma-inducible protein 16 |
|
| chr1_+_158979686 Show fit | 19.25 |
ENST00000368132.3
ENST00000295809.7 |
interferon, gamma-inducible protein 16 |
|
| chr1_+_158979680 Show fit | 19.19 |
ENST00000368131.4
ENST00000340979.6 |
interferon, gamma-inducible protein 16 |
|
| chr1_+_32757668 Show fit | 18.59 |
ENST00000373548.3
|
histone deacetylase 1 |
|
| chr16_-_67969888 Show fit | 17.65 |
ENST00000574576.2
|
proteasome (prosome, macropain) subunit, beta type, 10 |
|
| chr13_-_46716969 Show fit | 16.67 |
ENST00000435666.2
|
lymphocyte cytosolic protein 1 (L-plastin) |
|
| chr1_+_26644441 Show fit | 16.22 |
ENST00000374213.2
|
CD52 molecule |
|
| chr11_+_65769550 Show fit | 15.88 |
ENST00000312175.2
ENST00000445560.2 ENST00000530204.1 |
barrier to autointegration factor 1 |
|
| chr11_+_65769946 Show fit | 15.79 |
ENST00000533166.1
|
barrier to autointegration factor 1 |
|
| chr15_+_40453204 Show fit | 15.65 |
ENST00000287598.6
ENST00000412359.3 |
BUB1 mitotic checkpoint serine/threonine kinase B |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZBTB12
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 62.8 | GO:0032731 | positive regulation of interleukin-1 beta production(GO:0032731) |
| 5.5 | 33.0 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 2.6 | 31.7 | GO:0015074 | DNA integration(GO:0015074) |
| 7.3 | 29.2 | GO:0019747 | regulation of isoprenoid metabolic process(GO:0019747) |
| 0.3 | 26.1 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 5.0 | 25.1 | GO:0061198 | fungiform papilla formation(GO:0061198) |
| 0.2 | 23.9 | GO:0007062 | sister chromatid cohesion(GO:0007062) |
| 0.1 | 19.2 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 1.9 | 18.8 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 1.0 | 16.7 | GO:0051639 | actin filament network formation(GO:0051639) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 51.1 | GO:0016607 | nuclear speck(GO:0016607) |
| 2.8 | 33.0 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.1 | 31.7 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.3 | 29.2 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.1 | 27.2 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 1.0 | 25.1 | GO:0016580 | Sin3 complex(GO:0016580) |
| 6.0 | 23.9 | GO:1990423 | RZZ complex(GO:1990423) |
| 0.3 | 23.8 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 3.2 | 19.5 | GO:0072558 | NLRP1 inflammasome complex(GO:0072558) |
| 0.6 | 18.8 | GO:0035371 | microtubule plus-end(GO:0035371) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 48.8 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.3 | 45.7 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 1.3 | 33.0 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.1 | 31.1 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.5 | 29.2 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.9 | 26.1 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 25.7 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 25.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.8 | 25.1 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 1.9 | 18.8 | GO:0019237 | centromeric DNA binding(GO:0019237) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 18.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 1.2 | 18.6 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.6 | 15.8 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.2 | 15.8 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.3 | 15.6 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 9.7 | PID P73PATHWAY | p73 transcription factor network |
| 0.2 | 8.1 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.3 | 7.6 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.1 | 6.6 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.2 | 4.7 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 33.0 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 3.5 | 31.7 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.4 | 26.1 | REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C | Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C |
| 0.1 | 24.6 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.2 | 20.2 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.8 | 18.8 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.6 | 18.6 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.5 | 15.6 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.8 | 15.2 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.2 | 9.7 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |