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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ZBTB14
Z-value: 1.43
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Transcription factors associated with ZBTB14
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZBTB14 | hg19_v2_chr18_-_5296138_5296194 | 0.23 | 7.9e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZBTB14
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 145.4 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 1.5 | 89.4 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
| 11.4 | 68.7 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 22.4 | 67.1 | GO:0050760 | negative regulation of thymidylate synthase biosynthetic process(GO:0050760) |
| 22.1 | 66.2 | GO:0071139 | resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140) |
| 12.8 | 64.2 | GO:0090258 | negative regulation of mitochondrial fission(GO:0090258) |
| 1.8 | 59.5 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 4.3 | 55.7 | GO:0019336 | phenol-containing compound catabolic process(GO:0019336) |
| 4.0 | 55.7 | GO:0051823 | regulation of synapse structural plasticity(GO:0051823) |
| 17.6 | 52.8 | GO:2000374 | cadmium ion homeostasis(GO:0055073) negative regulation of hydrogen peroxide catabolic process(GO:2000296) regulation of oxygen metabolic process(GO:2000374) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 146.5 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.5 | 140.3 | GO:0060076 | excitatory synapse(GO:0060076) |
| 27.9 | 139.7 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
| 0.2 | 88.0 | GO:0000139 | Golgi membrane(GO:0000139) |
| 8.9 | 79.9 | GO:1990761 | growth cone lamellipodium(GO:1990761) |
| 0.7 | 72.1 | GO:0005814 | centriole(GO:0005814) |
| 0.3 | 65.8 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 12.8 | 64.2 | GO:0045298 | tubulin complex(GO:0045298) |
| 4.0 | 59.8 | GO:0005883 | neurofilament(GO:0005883) |
| 1.1 | 58.7 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.6 | 139.7 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 3.3 | 85.1 | GO:0031489 | myosin V binding(GO:0031489) |
| 8.3 | 66.2 | GO:0008821 | crossover junction endodeoxyribonuclease activity(GO:0008821) |
| 0.4 | 65.9 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 16.1 | 64.2 | GO:0099609 | microtubule lateral binding(GO:0099609) |
| 4.6 | 59.8 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 3.1 | 58.3 | GO:0048156 | tau protein binding(GO:0048156) |
| 4.1 | 53.7 | GO:0046870 | cadmium ion binding(GO:0046870) |
| 1.0 | 45.2 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 1.1 | 44.1 | GO:0046875 | ephrin receptor binding(GO:0046875) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 101.4 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 1.7 | 85.5 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.2 | 58.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.6 | 57.1 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.9 | 56.2 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 2.8 | 49.8 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 47.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.7 | 44.0 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 1.7 | 41.9 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.8 | 39.8 | PID RHOA PATHWAY | RhoA signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.5 | 180.0 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 2.3 | 77.7 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.3 | 56.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.2 | 55.8 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 1.7 | 55.7 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 1.3 | 48.5 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.2 | 33.8 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 2.7 | 32.9 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 1.2 | 30.4 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 1.9 | 29.7 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |