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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ZBTB3
Z-value: 0.22
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Transcription factors associated with ZBTB3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZBTB3 | hg19_v2_chr11_-_62521614_62521660 | -0.08 | 2.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZBTB3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.6 | 66.8 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 2.7 | 13.6 | GO:0030070 | insulin processing(GO:0030070) |
| 0.8 | 13.5 | GO:0060907 | positive regulation of macrophage cytokine production(GO:0060907) |
| 1.5 | 13.1 | GO:2001015 | negative regulation of skeletal muscle cell differentiation(GO:2001015) |
| 1.0 | 9.4 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.3 | 7.9 | GO:0060134 | prepulse inhibition(GO:0060134) |
| 0.1 | 7.6 | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862) |
| 1.8 | 7.2 | GO:0071492 | cellular response to UV-A(GO:0071492) |
| 2.2 | 6.5 | GO:1904530 | negative regulation of actin filament binding(GO:1904530) negative regulation of actin binding(GO:1904617) |
| 0.2 | 4.7 | GO:0008535 | respiratory chain complex IV assembly(GO:0008535) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 66.8 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.1 | 17.1 | GO:0030658 | transport vesicle membrane(GO:0030658) |
| 0.0 | 15.4 | GO:0030659 | cytoplasmic vesicle membrane(GO:0030659) |
| 0.1 | 12.6 | GO:0001726 | ruffle(GO:0001726) |
| 0.0 | 9.4 | GO:0043235 | receptor complex(GO:0043235) |
| 0.2 | 5.3 | GO:0032809 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.0 | 5.2 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.2 | 4.7 | GO:0031304 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
| 0.0 | 3.8 | GO:0030496 | midbody(GO:0030496) |
| 0.1 | 3.7 | GO:0005637 | nuclear inner membrane(GO:0005637) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 66.8 | GO:0003785 | actin monomer binding(GO:0003785) |
| 1.0 | 14.5 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.1 | 13.5 | GO:0030295 | protein kinase activator activity(GO:0030295) |
| 0.7 | 13.1 | GO:0048156 | tau protein binding(GO:0048156) |
| 1.9 | 9.4 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.1 | 7.6 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 1.2 | 7.2 | GO:0050291 | sphingosine N-acyltransferase activity(GO:0050291) |
| 0.3 | 6.5 | GO:0031005 | filamin binding(GO:0031005) |
| 0.0 | 5.5 | GO:0008565 | protein transporter activity(GO:0008565) |
| 1.5 | 4.6 | GO:0016495 | C-X3-C chemokine receptor activity(GO:0016495) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 66.8 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 21.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 13.6 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 2.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.9 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 66.8 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.5 | 13.6 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.4 | 13.1 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.3 | 7.6 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.2 | 6.5 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 4.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 3.4 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.1 | 3.1 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |
| 0.2 | 3.0 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.0 | 2.8 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |