ISMARA results: ZBTB4

Project

GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

Navigation

Downloads

Results for ZBTB4

Z-value: 0.18

Motif logo

Transcription factors associated with ZBTB4

Gene Symbol	Gene ID	Gene Info
ZBTB4 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000174282.7	zinc finger and BTB domain containing 4

Activity profile of ZBTB4 motif

Sorted Z-values of ZBTB4 motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_169075554 Show fit	20.88	ENST00000367815.4	ATP1B1 Ensembl NCBI GeneCards UniProt NextProt Show fit	ATPase, Na+/K+ transporting, beta 1 polypeptide
chr14_-_69445968 Show fit	19.21	ENST00000438964.2	ACTN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	actinin, alpha 1
chr14_-_69445793 Show fit	18.77	ENST00000538545.2 ENST00000394419.4	ACTN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	actinin, alpha 1
chr14_-_69446034 Show fit	16.09	ENST00000193403.6	ACTN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	actinin, alpha 1
chr8_-_27468842 Show fit	11.91	ENST00000523500.1	CLU Ensembl NCBI GeneCards UniProt NextProt Show fit	clusterin
chr3_-_57583185 Show fit	11.53	ENST00000463880.1	ARF4 Ensembl NCBI GeneCards UniProt NextProt Show fit	ADP-ribosylation factor 4
chr15_-_77363513 Show fit	11.36	ENST00000267970.4	TSPAN3 Ensembl NCBI GeneCards UniProt NextProt Show fit	tetraspanin 3
chr19_+_36631867 Show fit	10.91	ENST00000588780.1	CAPNS1 Ensembl NCBI GeneCards UniProt NextProt Show fit	calpain, small subunit 1
chr19_+_47104553 Show fit	10.39	ENST00000598871.1 ENST00000594523.1	CALM3 Ensembl NCBI GeneCards UniProt NextProt Show fit	calmodulin 3 (phosphorylase kinase, delta)
chr11_+_86511569 Show fit	9.86	ENST00000441050.1	PRSS23 Ensembl NCBI GeneCards UniProt NextProt Show fit	protease, serine, 23

Showing 1 to 10 of 162 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB4

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
3.4	54.1	GO:0051639	actin filament network formation(GO:0051639)
2.7	29.4	GO:0031584	activation of phospholipase D activity(GO:0031584) apical protein localization(GO:0045176)
4.7	28.0	GO:0061517	macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
3.8	22.5	GO:0070315	G1 to G0 transition involved in cell differentiation(GO:0070315)
5.2	20.9	GO:1903288	protein transport into plasma membrane raft(GO:0044861) positive regulation of potassium ion import(GO:1903288)
0.0	14.0	GO:0016567	protein ubiquitination(GO:0016567)
0.1	13.2	GO:0006892	post-Golgi vesicle-mediated transport(GO:0006892)
3.9	11.7	GO:1902396	protein localization to bicellular tight junction(GO:1902396)
1.0	11.5	GO:0006983	ER overload response(GO:0006983)
0.1	10.9	GO:0070268	cornification(GO:0070268)

Showing 1 to 10 of 96 entries

Gene overrepresentation in cellular_component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
3.6	54.1	GO:0005916	fascia adherens(GO:0005916)
0.2	29.4	GO:0043197	dendritic spine(GO:0043197)
1.8	28.0	GO:0097418	neurofibrillary tangle(GO:0097418)
1.0	20.9	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.3	20.8	GO:0030315	T-tubule(GO:0030315)
0.1	19.2	GO:0000922	spindle pole(GO:0000922)
0.2	17.6	GO:0016459	myosin complex(GO:0016459)
0.0	14.6	GO:0005759	mitochondrial matrix(GO:0005759)
0.1	13.4	GO:0055037	recycling endosome(GO:0055037)
0.5	11.7	GO:0031143	pseudopodium(GO:0031143)

Showing 1 to 10 of 70 entries

Gene overrepresentation in molecular_function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
2.2	54.1	GO:0017166	vinculin binding(GO:0017166)
1.8	43.4	GO:0031402	sodium ion binding(GO:0031402)
1.1	29.4	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
1.4	28.0	GO:0051787	misfolded protein binding(GO:0051787)
0.8	17.6	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.1	16.6	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
0.0	12.1	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.3	11.7	GO:0042974	retinoic acid receptor binding(GO:0042974)
0.3	10.9	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2	10.8	GO:0051879	Hsp90 protein binding(GO:0051879)

Showing 1 to 10 of 77 entries

Gene overrepresentation in C2:CP category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.8	49.7	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.2	32.7	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.2	31.4	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.1	15.3	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
0.3	11.3	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.2	10.5	PID LKB1 PATHWAY	LKB1 signaling events
0.3	9.4	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.1	6.8	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	6.2	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	5.9	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I

Showing 1 to 10 of 21 entries

Gene overrepresentation in C2:CP:REACTOME category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
2.1	65.7	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.8	35.3	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.2	28.0	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
1.0	19.3	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1	16.6	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.4	11.7	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.1	8.6	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.3	7.2	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.4	6.8	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.3	6.6	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)

Showing 1 to 10 of 39 entries

Results for ZBTB4

Z-value: 0.18

Motif logo

Transcription factors associated with ZBTB4

Activity profile of ZBTB4 motif

Sorted Z-values of ZBTB4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB4

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: