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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ZBTB49
Z-value: 0.75
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Transcription factors associated with ZBTB49
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_2950642 Show fit | 19.45 |
ENST00000314222.4
|
pleckstrin homology-like domain, family A, member 2 |
|
| chrX_-_151903184 Show fit | 13.49 |
ENST00000357916.4
ENST00000393869.3 |
melanoma antigen family A, 12 |
|
| chr20_+_1115821 Show fit | 13.25 |
ENST00000435720.1
|
proteasome (prosome, macropain) inhibitor subunit 1 (PI31) |
|
| chr10_+_94352956 Show fit | 13.11 |
ENST00000260731.3
|
kinesin family member 11 |
|
| chr12_+_53835383 Show fit | 11.44 |
ENST00000429243.2
|
proline rich 13 |
|
| chrX_-_151903101 Show fit | 10.76 |
ENST00000393900.3
|
melanoma antigen family A, 12 |
|
| chr12_+_53835539 Show fit | 10.52 |
ENST00000547368.1
ENST00000379786.4 ENST00000551945.1 |
proline rich 13 |
|
| chr21_-_26979786 Show fit | 9.26 |
ENST00000419219.1
ENST00000352957.4 ENST00000307301.7 |
mitochondrial ribosomal protein L39 |
|
| chr14_+_35591928 Show fit | 9.09 |
ENST00000605870.1
ENST00000557404.3 |
KIAA0391 |
|
| chr19_+_18669809 Show fit | 8.70 |
ENST00000602094.1
|
KxDL motif containing 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZBTB49
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 23.2 | GO:0090646 | mitochondrial tRNA processing(GO:0090646) |
| 1.1 | 19.4 | GO:0060712 | spongiotrophoblast layer development(GO:0060712) |
| 0.7 | 16.6 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 0.4 | 15.1 | GO:0061014 | positive regulation of mRNA catabolic process(GO:0061014) |
| 0.2 | 13.2 | GO:1901799 | negative regulation of proteasomal protein catabolic process(GO:1901799) |
| 0.7 | 13.1 | GO:0046602 | regulation of mitotic centrosome separation(GO:0046602) |
| 2.1 | 12.6 | GO:0022614 | membrane to membrane docking(GO:0022614) |
| 0.2 | 12.0 | GO:0070126 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
| 1.3 | 10.6 | GO:2000825 | positive regulation of androgen receptor activity(GO:2000825) |
| 0.1 | 8.7 | GO:0032418 | lysosome localization(GO:0032418) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.6 | 23.2 | GO:0030678 | mitochondrial ribonuclease P complex(GO:0030678) |
| 0.3 | 19.2 | GO:0005876 | spindle microtubule(GO:0005876) |
| 4.2 | 16.6 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 1.5 | 15.1 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.4 | 13.2 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.6 | 12.2 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 12.1 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.4 | 10.0 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.2 | 9.3 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.5 | 8.7 | GO:0031083 | BLOC-1 complex(GO:0031083) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 21.6 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 4.2 | 16.6 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.8 | 15.1 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.6 | 13.2 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.4 | 13.1 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.2 | 10.0 | GO:0031369 | translation initiation factor binding(GO:0031369) |
| 2.1 | 8.2 | GO:0015142 | citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142) |
| 0.1 | 8.0 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.2 | 7.4 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.1 | 7.4 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.6 | PID E2F PATHWAY | E2F transcription factor network |
| 0.2 | 12.6 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.2 | 7.4 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.1 | 6.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 6.6 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.1 | 6.4 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.2 | 5.6 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 4.3 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 3.2 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 3.1 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 20.0 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.5 | 16.6 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.4 | 15.1 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 1.0 | 13.5 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.2 | 13.2 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.5 | 13.1 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.2 | 12.4 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.3 | 8.2 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.0 | 5.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 5.7 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |