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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ZEB1
Z-value: 0.56
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Transcription factors associated with ZEB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZEB1 | hg19_v2_chr10_+_31610064_31610159 | -0.27 | 6.4e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZEB1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 220.2 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 32.2 | 160.9 | GO:1904274 | tricellular tight junction assembly(GO:1904274) |
| 0.3 | 149.2 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 33.5 | 134.0 | GO:0060671 | epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672) |
| 3.8 | 109.9 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 16.0 | 80.0 | GO:0002159 | desmosome assembly(GO:0002159) |
| 0.9 | 76.7 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 9.2 | 73.7 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 4.6 | 64.6 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 6.4 | 63.5 | GO:0070863 | positive regulation of protein exit from endoplasmic reticulum(GO:0070863) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 503.5 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 309.3 | GO:0016021 | integral component of membrane(GO:0016021) |
| 26.8 | 160.9 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 4.8 | 148.7 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 7.3 | 109.4 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.9 | 98.2 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.7 | 83.9 | GO:0070160 | occluding junction(GO:0070160) |
| 1.1 | 83.2 | GO:0034707 | chloride channel complex(GO:0034707) |
| 2.9 | 82.7 | GO:0030057 | desmosome(GO:0030057) |
| 0.4 | 70.2 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 297.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 2.1 | 226.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 13.7 | 123.4 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.4 | 110.3 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 1.0 | 99.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 85.1 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 1.4 | 70.4 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.9 | 67.1 | GO:0005254 | chloride channel activity(GO:0005254) |
| 2.4 | 63.0 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.4 | 55.3 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 167.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.6 | 101.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 1.1 | 92.9 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 1.1 | 73.4 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 3.2 | 69.9 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 1.9 | 69.9 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 1.1 | 60.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.8 | 39.7 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.5 | 37.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 1.1 | 34.8 | PID NECTIN PATHWAY | Nectin adhesion pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 155.9 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 4.5 | 85.7 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.5 | 81.4 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 2.8 | 80.8 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 1.9 | 73.0 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 3.3 | 65.7 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 1.2 | 64.4 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 0.9 | 48.8 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.5 | 47.4 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.6 | 42.4 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |