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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ZFHX3
Z-value: 0.16
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Transcription factors associated with ZFHX3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZFHX3 | hg19_v2_chr16_-_73082274_73082274, hg19_v2_chr16_-_73093597_73093597 | 0.04 | 5.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZFHX3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.9 | GO:0007498 | mesoderm development(GO:0007498) |
| 1.1 | 6.9 | GO:0006789 | bilirubin conjugation(GO:0006789) |
| 0.3 | 5.6 | GO:0034374 | low-density lipoprotein particle remodeling(GO:0034374) |
| 1.1 | 5.4 | GO:0061107 | seminal vesicle development(GO:0061107) |
| 0.5 | 5.4 | GO:0051918 | negative regulation of fibrinolysis(GO:0051918) |
| 0.5 | 5.0 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.6 | 4.4 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 1.4 | 4.1 | GO:2000048 | interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
| 0.5 | 3.2 | GO:0015760 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 1.0 | 2.9 | GO:0010760 | negative regulation of macrophage chemotaxis(GO:0010760) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.1 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 1.8 | 5.4 | GO:0097182 | protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183) |
| 0.3 | 5.4 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.4 | 5.0 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.2 | 4.7 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 1.1 | 4.4 | GO:0071062 | rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.7 | 4.1 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.1 | 3.9 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 3.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 3.2 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.9 | GO:0001972 | retinoic acid binding(GO:0001972) glucuronosyltransferase activity(GO:0015020) |
| 0.3 | 5.6 | GO:0034185 | apolipoprotein binding(GO:0034185) |
| 0.0 | 5.6 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 1.1 | 5.4 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.6 | 5.4 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.0 | 4.7 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.3 | 4.4 | GO:0001871 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.5 | 4.1 | GO:1990405 | protein antigen binding(GO:1990405) |
| 0.0 | 3.7 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.8 | 3.2 | GO:0004346 | glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.5 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 5.4 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 3.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 2.5 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.0 | 2.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.7 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.0 | 1.3 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 0.6 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.9 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.2 | 4.7 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.3 | 4.2 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.2 | 4.1 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 4.0 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 3.2 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.1 | 2.6 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.1 | 2.4 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 2.4 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 2.0 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |