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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ZIC1
Z-value: 0.99
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Transcription factors associated with ZIC1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZIC1 | hg19_v2_chr3_+_147127142_147127171 | 0.11 | 9.3e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZIC1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 25.9 | GO:1904837 | beta-catenin-TCF complex assembly(GO:1904837) |
| 0.9 | 22.7 | GO:0001502 | cartilage condensation(GO:0001502) |
| 0.3 | 19.5 | GO:0010039 | response to iron ion(GO:0010039) |
| 1.5 | 16.5 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
| 5.3 | 16.0 | GO:1902995 | regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995) |
| 1.8 | 15.9 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 1.0 | 14.3 | GO:0042738 | exogenous drug catabolic process(GO:0042738) |
| 0.0 | 14.2 | GO:0001558 | regulation of cell growth(GO:0001558) |
| 0.9 | 14.1 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
| 0.9 | 13.0 | GO:0006751 | glutathione catabolic process(GO:0006751) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 40.0 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 38.6 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.2 | 23.4 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 22.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 3.9 | 19.5 | GO:0005602 | complement component C1 complex(GO:0005602) |
| 0.0 | 17.9 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.2 | 16.3 | GO:0005811 | lipid particle(GO:0005811) |
| 5.3 | 16.0 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 0.1 | 15.1 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.4 | 13.3 | GO:0030132 | clathrin coat of coated pit(GO:0030132) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 32.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 31.1 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.6 | 24.3 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.0 | 21.3 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.2 | 18.6 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 1.0 | 18.4 | GO:0008391 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
| 2.1 | 16.5 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 5.3 | 16.0 | GO:0070326 | very-low-density lipoprotein particle receptor binding(GO:0070326) |
| 3.5 | 14.1 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 1.2 | 10.8 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 37.2 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.2 | 30.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 18.6 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.2 | 15.7 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 9.5 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.2 | 8.3 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.2 | 7.4 | PID S1P S1P3 PATHWAY | S1P3 pathway |
| 0.1 | 7.0 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 6.5 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.5 | 5.7 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 25.9 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 1.8 | 19.5 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 1.6 | 16.5 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.7 | 16.0 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.6 | 15.9 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.3 | 15.9 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.8 | 14.3 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.4 | 13.3 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.1 | 11.4 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.1 | 8.8 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |