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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ZIC2_GLI1
Z-value: 1.36
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Transcription factors associated with ZIC2_GLI1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GLI1 | hg19_v2_chr12_+_57857475_57857475 | 0.78 | 1.6e-46 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZIC2_GLI1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.9 | 231.8 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 4.3 | 60.8 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 3.4 | 40.6 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
| 1.2 | 38.5 | GO:0034080 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 3.8 | 37.5 | GO:0009249 | protein lipoylation(GO:0009249) |
| 0.3 | 36.7 | GO:0007286 | spermatid development(GO:0007286) |
| 6.0 | 36.1 | GO:2000348 | regulation of CD40 signaling pathway(GO:2000348) |
| 4.4 | 35.1 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 1.7 | 33.5 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 4.7 | 32.8 | GO:0002175 | protein localization to paranode region of axon(GO:0002175) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.5 | 231.8 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.4 | 41.5 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.1 | 35.9 | GO:0001726 | ruffle(GO:0001726) |
| 0.4 | 35.1 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 1.0 | 33.5 | GO:1902711 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
| 2.7 | 32.8 | GO:0033010 | paranodal junction(GO:0033010) |
| 1.0 | 32.0 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 1.2 | 26.7 | GO:0044295 | axonal growth cone(GO:0044295) |
| 7.7 | 23.1 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 3.1 | 21.8 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.6 | 236.1 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.3 | 43.5 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.4 | 37.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 1.0 | 36.1 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 2.2 | 35.1 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 1.3 | 24.1 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 7.7 | 23.1 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 1.7 | 21.5 | GO:0008503 | benzodiazepine receptor activity(GO:0008503) |
| 0.0 | 20.9 | GO:0008047 | enzyme activator activity(GO:0008047) |
| 1.9 | 20.8 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 57.8 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.2 | 39.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.8 | 29.4 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.8 | 26.1 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.3 | 18.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.6 | 16.3 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.2 | 14.9 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.3 | 13.9 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.2 | 12.5 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.4 | 10.0 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 40.7 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 2.8 | 36.1 | REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 1.1 | 33.5 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.3 | 32.8 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 1.4 | 25.6 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 1.6 | 21.8 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.5 | 21.5 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.8 | 20.8 | REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR | Genes involved in Prostacyclin signalling through prostacyclin receptor |
| 0.6 | 17.2 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.5 | 17.1 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |