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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for ZIC3_ZIC4

Z-value: 0.01

Motif logo

Transcription factors associated with ZIC3_ZIC4

Gene Symbol Gene ID Gene Info
ENSG00000156925.7 Zic family member 3
ENSG00000174963.13 Zic family member 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZIC3hg19_v2_chrX_+_136648297_136648319-0.054.5e-01Click!

Activity profile of ZIC3_ZIC4 motif

Sorted Z-values of ZIC3_ZIC4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_2182388 7.05 ENST00000421783.1
ENST00000397262.1
ENST00000250971.3
ENST00000381330.4
ENST00000397270.1
insulin
INS-IGF2 readthrough
chr7_-_994302 6.50 ENST00000265846.5
ArfGAP with dual PH domains 1
chr5_+_75699149 5.85 ENST00000379730.3
IQ motif containing GTPase activating protein 2
chr5_+_75699040 5.57 ENST00000274364.6
IQ motif containing GTPase activating protein 2
chr16_-_88717482 5.20 ENST00000261623.3
cytochrome b-245, alpha polypeptide
chr7_+_149571045 4.67 ENST00000479613.1
ENST00000606024.1
ENST00000464662.1
ENST00000425642.2
ATPase, H+ transporting V0 subunit e2
chr11_-_67272794 3.89 ENST00000436757.2
ENST00000356404.3
phosphatidylinositol transfer protein, membrane-associated 1
chr6_+_44238203 3.77 ENST00000451188.2
transmembrane protein 151B
chr4_+_166128735 3.58 ENST00000226725.6
kelch-like family member 2
chr17_-_1083078 3.52 ENST00000574266.1
ENST00000302538.5
active BCR-related
chrX_-_102319092 3.36 ENST00000372728.3
brain expressed, X-linked 1
chr15_+_31619013 3.22 ENST00000307145.3
Kruppel-like factor 13
chr11_+_121322832 3.14 ENST00000260197.7
sortilin-related receptor, L(DLR class) A repeats containing
chr4_-_106395135 2.99 ENST00000310267.7
pyrophosphatase (inorganic) 2
chr4_-_40631859 2.87 ENST00000295971.7
ENST00000319592.4
RNA binding motif protein 47
chr4_-_17513851 2.80 ENST00000281243.5
quinoid dihydropteridine reductase
chr1_+_155293702 2.76 ENST00000368347.4
RUN and SH3 domain containing 1
chr6_-_29600832 2.74 ENST00000377016.4
ENST00000376977.3
ENST00000377034.4
gamma-aminobutyric acid (GABA) B receptor, 1
chr17_-_4871085 2.65 ENST00000575142.1
ENST00000206020.3
sperm associated antigen 7
chr1_-_32801825 2.61 ENST00000329421.7
MARCKS-like 1
chr15_+_75074385 2.46 ENST00000220003.9
c-src tyrosine kinase
chrX_+_51927919 2.41 ENST00000416960.1
melanoma antigen family D, 4
chr6_+_150070831 2.40 ENST00000367380.5
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr17_-_4890919 2.33 ENST00000572543.1
ENST00000381311.5
ENST00000348066.3
ENST00000358183.4
calmodulin binding transcription activator 2
chr16_+_2039946 2.33 ENST00000248121.2
ENST00000568896.1
synaptogyrin 3
chr16_+_56623433 2.32 ENST00000570176.1
metallothionein 3
chr11_-_78128811 2.28 ENST00000530915.1
ENST00000361507.4
GRB2-associated binding protein 2
chr17_-_4890649 2.26 ENST00000361571.5
calmodulin binding transcription activator 2
chr8_-_67976509 2.26 ENST00000518747.1
COP9 signalosome subunit 5
chr4_+_154387480 2.21 ENST00000409663.3
ENST00000440693.1
ENST00000409959.3
KIAA0922
chr16_+_58497567 2.17 ENST00000258187.5
NDRG family member 4
chr16_+_30205754 2.07 ENST00000354723.6
ENST00000355544.5
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr22_-_22221900 2.06 ENST00000215832.6
ENST00000398822.3
mitogen-activated protein kinase 1
chr3_+_11034403 2.04 ENST00000287766.4
ENST00000425938.1
solute carrier family 6 (neurotransmitter transporter), member 1
chr1_-_25256368 2.00 ENST00000308873.6
runt-related transcription factor 3
chr20_-_62129163 2.00 ENST00000298049.7
eukaryotic translation elongation factor 1 alpha 2
chr16_+_67596310 1.98 ENST00000264010.4
ENST00000401394.1
CCCTC-binding factor (zinc finger protein)
chrX_+_123095155 1.97 ENST00000371160.1
ENST00000435103.1
stromal antigen 2
chr10_-_88854518 1.94 ENST00000277865.4
glutamate dehydrogenase 1
chr2_+_37571717 1.94 ENST00000338415.3
ENST00000404976.1
glutaminyl-peptide cyclotransferase
chr1_+_33352036 1.94 ENST00000373467.3
hippocalcin
chr12_-_57824739 1.93 ENST00000347140.3
ENST00000402412.1
R3H domain containing 2
chr5_+_169064245 1.93 ENST00000256935.8
dedicator of cytokinesis 2
chr2_+_37571845 1.92 ENST00000537448.1
glutaminyl-peptide cyclotransferase
chr3_+_54156664 1.91 ENST00000474759.1
ENST00000288197.5
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr14_+_31343747 1.90 ENST00000216361.4
ENST00000396618.3
ENST00000475087.1
cochlin
chr2_+_8822113 1.89 ENST00000396290.1
ENST00000331129.3
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr12_+_132312931 1.86 ENST00000360564.1
ENST00000545671.1
ENST00000545790.1
matrix metallopeptidase 17 (membrane-inserted)
chr6_+_150070857 1.85 ENST00000544496.1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr1_-_114355083 1.84 ENST00000261441.5
round spermatid basic protein 1
chr9_-_88356789 1.82 ENST00000357081.3
ENST00000376081.4
ENST00000337006.4
ENST00000376109.3
ATP/GTP binding protein 1
chr3_+_54156570 1.78 ENST00000415676.2
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr5_-_179499086 1.77 ENST00000261947.4
ring finger protein 130
chr15_+_75074410 1.77 ENST00000439220.2
c-src tyrosine kinase
chr11_-_64510409 1.77 ENST00000394429.1
ENST00000394428.1
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr14_-_93651186 1.74 ENST00000556883.1
ENST00000298894.4
modulator of apoptosis 1
chr19_+_17858509 1.74 ENST00000594202.1
ENST00000252771.7
ENST00000389133.4
FCH domain only 1
chr5_+_137688285 1.73 ENST00000314358.5
lysine (K)-specific demethylase 3B
chr5_-_179499108 1.73 ENST00000521389.1
ring finger protein 130
chr15_-_69113218 1.71 ENST00000560303.1
ENST00000465139.2
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr9_+_115913222 1.68 ENST00000259392.3
solute carrier family 31 (copper transporter), member 2
chr16_+_30205225 1.68 ENST00000345535.4
ENST00000251303.6
SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)
chr16_+_29465822 1.67 ENST00000330181.5
ENST00000351581.4
SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
chr22_-_47134077 1.67 ENST00000541677.1
ENST00000216264.8
ceramide kinase
chr11_-_73694346 1.64 ENST00000310473.3
uncoupling protein 2 (mitochondrial, proton carrier)
chr11_-_57004658 1.64 ENST00000606794.1
apelin receptor
chr11_-_407103 1.63 ENST00000526395.1
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr15_+_80696666 1.58 ENST00000303329.4
aryl-hydrocarbon receptor nuclear translocator 2
chr5_-_179498703 1.56 ENST00000522208.2
ring finger protein 130
chr17_-_76124812 1.54 ENST00000592063.1
ENST00000589271.1
ENST00000322933.4
ENST00000589553.1
transmembrane channel-like 6
chr20_+_35201993 1.53 ENST00000373872.4
TGFB-induced factor homeobox 2
chr3_+_50712672 1.49 ENST00000266037.9
dedicator of cytokinesis 3
chr3_-_129035120 1.49 ENST00000333762.4
H1 histone family, member X
chr1_-_21503337 1.47 ENST00000400422.1
ENST00000602326.1
ENST00000411888.1
ENST00000438975.1
eukaryotic translation initiation factor 4 gamma, 3
chr9_-_140351928 1.47 ENST00000339554.3
NMDA receptor synaptonuclear signaling and neuronal migration factor
chr2_-_96811170 1.45 ENST00000288943.4
dual specificity phosphatase 2
chr2_+_79740118 1.44 ENST00000496558.1
ENST00000451966.1
catenin (cadherin-associated protein), alpha 2
chr2_-_98280383 1.41 ENST00000289228.5
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chr20_+_3869423 1.38 ENST00000497424.1
pantothenate kinase 2
chrX_+_123094672 1.37 ENST00000354548.5
ENST00000458700.1
stromal antigen 2
chr1_-_153521597 1.37 ENST00000368712.1
S100 calcium binding protein A3
chr19_+_54926601 1.37 ENST00000301194.4
tweety family member 1
chr2_+_128180842 1.36 ENST00000402125.2
protein C (inactivator of coagulation factors Va and VIIIa)
chr14_-_21994525 1.35 ENST00000538754.1
spalt-like transcription factor 2
chrX_+_106871713 1.35 ENST00000372435.4
ENST00000372428.4
ENST00000372419.3
ENST00000543248.1
phosphoribosyl pyrophosphate synthetase 1
chr20_+_35201857 1.34 ENST00000373874.2
TGFB-induced factor homeobox 2
chr3_+_38206975 1.33 ENST00000446845.1
ENST00000311806.3
oxidative stress responsive 1
chr3_-_33686743 1.33 ENST00000333778.6
ENST00000539981.1
cytoplasmic linker associated protein 2
chr10_+_51572339 1.32 ENST00000344348.6
nuclear receptor coactivator 4
chr7_-_100808394 1.32 ENST00000445482.2
VGF nerve growth factor inducible
chr19_-_12992244 1.29 ENST00000538460.1
deoxyribonuclease II, lysosomal
chr3_+_184097836 1.29 ENST00000204604.1
ENST00000310236.3
chordin
chr3_-_33759699 1.27 ENST00000399362.4
ENST00000359576.5
ENST00000307312.7
cytoplasmic linker associated protein 2
chr7_-_100808843 1.26 ENST00000249330.2
VGF nerve growth factor inducible
chrX_+_123095546 1.26 ENST00000371157.3
ENST00000371145.3
ENST00000371144.3
stromal antigen 2
chr3_-_33759541 1.25 ENST00000468888.2
cytoplasmic linker associated protein 2
chr1_+_28995231 1.25 ENST00000373816.1
glucocorticoid modulatory element binding protein 1
chr7_+_65540780 1.24 ENST00000304874.9
argininosuccinate lyase
chr14_+_100848311 1.22 ENST00000542471.2
WD repeat domain 25
chr9_+_131580734 1.20 ENST00000372642.4
endonuclease G
chrX_-_153881842 1.20 ENST00000369585.3
ENST00000247306.4
cancer/testis antigen 2
chr19_+_45409011 1.19 ENST00000252486.4
ENST00000446996.1
ENST00000434152.1
apolipoprotein E
chr14_+_71108460 1.18 ENST00000256367.2
tetratricopeptide repeat domain 9
chr19_+_10531150 1.17 ENST00000352831.6
phosphodiesterase 4A, cAMP-specific
chr19_+_54926621 1.17 ENST00000376530.3
ENST00000445095.1
ENST00000391739.3
ENST00000376531.3
tweety family member 1
chr1_+_146714291 1.14 ENST00000431239.1
ENST00000369259.3
ENST00000369258.4
ENST00000361293.5
chromodomain helicase DNA binding protein 1-like
chr10_-_43903217 1.14 ENST00000357065.4
heterogeneous nuclear ribonucleoprotein F
chr9_+_100174232 1.14 ENST00000355295.4
tudor domain containing 7
chr3_-_50540854 1.14 ENST00000423994.2
ENST00000424201.2
ENST00000479441.1
ENST00000429770.1
calcium channel, voltage-dependent, alpha 2/delta subunit 2
chr17_-_43045439 1.13 ENST00000253407.3
complement component 1, q subcomponent-like 1
chrX_+_41192595 1.12 ENST00000399959.2
DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
chr7_-_752577 1.09 ENST00000544935.1
ENST00000430040.1
ENST00000456696.2
ENST00000406797.1
protein kinase, cAMP-dependent, regulatory, type I, beta
chr14_+_57046500 1.09 ENST00000261556.6
transmembrane protein 260
chr16_-_11681023 1.09 ENST00000570904.1
ENST00000574701.1
lipopolysaccharide-induced TNF factor
chr11_-_62477041 1.08 ENST00000433053.1
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr8_-_80993010 1.08 ENST00000537855.1
ENST00000520527.1
ENST00000517427.1
ENST00000448733.2
ENST00000379097.3
tumor protein D52
chr16_+_89989687 1.07 ENST00000315491.7
ENST00000555576.1
ENST00000554336.1
ENST00000553967.1
Tubulin beta-3 chain
chr3_+_38179969 1.07 ENST00000396334.3
ENST00000417037.2
ENST00000424893.1
ENST00000495303.1
ENST00000443433.2
ENST00000421516.1
myeloid differentiation primary response 88
chr11_+_64692143 1.06 ENST00000164133.2
ENST00000532850.1
protein phosphatase 2, regulatory subunit B', beta
chr3_-_133614597 1.06 ENST00000285208.4
ENST00000460865.3
RAB6B, member RAS oncogene family
chr16_-_30205627 1.04 ENST00000305321.4
bolA family member 2B
chr2_-_99552620 1.04 ENST00000428096.1
ENST00000397899.2
ENST00000420294.1
KIAA1211-like
chr16_-_1993260 1.04 ENST00000361871.3
methionine sulfoxide reductase B1
chr11_+_2466218 1.03 ENST00000155840.5
potassium voltage-gated channel, KQT-like subfamily, member 1
chr3_-_64009658 1.02 ENST00000394431.2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
chr3_+_184097905 1.02 ENST00000450923.1
chordin
chr1_+_28995258 1.01 ENST00000361872.4
ENST00000294409.2
glucocorticoid modulatory element binding protein 1
chr20_+_3870024 1.00 ENST00000610179.1
pantothenate kinase 2
chr4_+_74718906 0.99 ENST00000226524.3
platelet factor 4 variant 1
chr4_-_106395197 0.99 ENST00000508518.1
ENST00000354147.3
ENST00000432483.2
ENST00000510015.1
ENST00000504028.1
ENST00000348706.5
ENST00000357415.4
ENST00000380004.2
ENST00000341695.5
pyrophosphatase (inorganic) 2
chr16_+_56691911 0.99 ENST00000568475.1
metallothionein 1F
chr10_+_45455207 0.97 ENST00000334940.6
ENST00000374417.2
ENST00000340258.5
ENST00000427758.1
Ras association (RalGDS/AF-6) domain family member 4
chr16_-_11680791 0.97 ENST00000571976.1
ENST00000413364.2
lipopolysaccharide-induced TNF factor
chr1_+_156024552 0.97 ENST00000368304.5
ENST00000368302.3
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
chr16_-_29466285 0.97 ENST00000330978.3
bolA family member 2
chr17_-_39191107 0.96 ENST00000344363.5
keratin associated protein 1-3
chr15_-_91565770 0.96 ENST00000535906.1
ENST00000333371.3
vacuolar protein sorting 33 homolog B (yeast)
chr6_+_15246501 0.96 ENST00000341776.2
jumonji, AT rich interactive domain 2
chr7_+_128577972 0.95 ENST00000357234.5
ENST00000477535.1
ENST00000479582.1
ENST00000464557.1
ENST00000402030.2
interferon regulatory factor 5
chr9_-_140082983 0.95 ENST00000323927.2
anaphase promoting complex subunit 2
chr15_-_66790146 0.95 ENST00000316634.5
small nuclear RNA activating complex, polypeptide 5, 19kDa
chr2_+_65216462 0.94 ENST00000234256.3
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr1_-_6240183 0.94 ENST00000262450.3
ENST00000378021.1
chromodomain helicase DNA binding protein 5
chr2_+_134877740 0.94 ENST00000409645.1
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
chr14_+_91580357 0.94 ENST00000298858.4
ENST00000521081.1
ENST00000520328.1
ENST00000256324.10
ENST00000524232.1
ENST00000522170.1
ENST00000519950.1
ENST00000523879.1
ENST00000521077.2
ENST00000518665.2
chromosome 14 open reading frame 159
chr11_+_47291193 0.93 ENST00000428807.1
ENST00000402799.1
ENST00000406482.1
ENST00000349238.3
ENST00000311027.5
ENST00000407859.3
ENST00000395344.3
ENST00000444117.1
MAP-kinase activating death domain
chr7_+_65540853 0.93 ENST00000380839.4
ENST00000395332.3
ENST00000362000.5
ENST00000395331.3
argininosuccinate lyase
chr17_+_38219063 0.93 ENST00000584985.1
ENST00000264637.4
ENST00000450525.2
thyroid hormone receptor, alpha
chr1_-_212873267 0.92 ENST00000243440.1
basic leucine zipper transcription factor, ATF-like 3
chr8_-_41522719 0.92 ENST00000335651.6
ankyrin 1, erythrocytic
chr14_+_91580732 0.92 ENST00000519019.1
ENST00000523816.1
ENST00000517518.1
chromosome 14 open reading frame 159
chr14_+_91580708 0.91 ENST00000518868.1
chromosome 14 open reading frame 159
chr4_+_115519577 0.91 ENST00000310836.6
UDP glycosyltransferase 8
chr14_+_91580777 0.91 ENST00000525393.2
ENST00000428926.2
ENST00000517362.1
chromosome 14 open reading frame 159
chr12_-_51785182 0.91 ENST00000356317.3
ENST00000603188.1
ENST00000604847.1
ENST00000604506.1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)
chr14_-_23822080 0.90 ENST00000397267.1
ENST00000354772.3
solute carrier family 22, member 17
chr1_+_109792641 0.90 ENST00000271332.3
cadherin, EGF LAG seven-pass G-type receptor 2
chr20_-_2644832 0.90 ENST00000380851.5
ENST00000380843.4
isocitrate dehydrogenase 3 (NAD+) beta
chr1_-_55680762 0.89 ENST00000407756.1
ENST00000294383.6
ubiquitin specific peptidase 24
chr1_-_151119087 0.89 ENST00000341697.3
ENST00000368914.3
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
chr1_+_156024525 0.87 ENST00000368305.4
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
chr19_+_13135731 0.87 ENST00000587260.1
nuclear factor I/X (CCAAT-binding transcription factor)
chr10_+_28821674 0.87 ENST00000526722.1
ENST00000375646.1
WW domain containing adaptor with coiled-coil
chrX_-_49056635 0.86 ENST00000472598.1
ENST00000538567.1
ENST00000479808.1
ENST00000263233.4
synaptophysin
chr6_-_29595779 0.86 ENST00000355973.3
ENST00000377012.4
gamma-aminobutyric acid (GABA) B receptor, 1
chr1_-_45308616 0.86 ENST00000447098.2
ENST00000372192.3
patched 2
chr17_-_38721711 0.85 ENST00000578085.1
ENST00000246657.2
chemokine (C-C motif) receptor 7
chr21_+_45725050 0.85 ENST00000403390.1
phosphofructokinase, liver
chr8_-_41522779 0.85 ENST00000522231.1
ENST00000314214.8
ENST00000348036.4
ENST00000457297.1
ENST00000522543.1
ankyrin 1, erythrocytic
chr10_+_13142075 0.84 ENST00000378757.2
ENST00000430081.1
ENST00000378752.3
ENST00000378748.3
optineurin
chr15_-_91565743 0.84 ENST00000535843.1
vacuolar protein sorting 33 homolog B (yeast)
chr1_+_2407754 0.83 ENST00000419816.2
ENST00000378486.3
ENST00000378488.3
ENST00000288766.5
phospholipase C, eta 2
chr14_+_57046530 0.83 ENST00000536419.1
ENST00000538838.1
transmembrane protein 260
chr13_-_95131923 0.83 ENST00000377028.5
ENST00000446125.1
dopachrome tautomerase
chr19_+_55105085 0.83 ENST00000251372.3
ENST00000453777.1
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
chr16_-_74808710 0.82 ENST00000219368.3
ENST00000544337.1
fatty acid 2-hydroxylase
chr12_-_323689 0.82 ENST00000428720.1
solute carrier family 6 (neurotransmitter transporter), member 12
chr19_+_13135790 0.81 ENST00000358552.3
nuclear factor I/X (CCAAT-binding transcription factor)
chr1_-_153521714 0.81 ENST00000368713.3
S100 calcium binding protein A3
chr19_+_49617581 0.81 ENST00000391864.3
lin-7 homolog B (C. elegans)
chr17_-_50236039 0.79 ENST00000451037.2
carbonic anhydrase X
chr11_+_64781575 0.79 ENST00000246747.4
ENST00000529384.1
ADP-ribosylation factor-like 2
chr9_+_134269439 0.79 ENST00000405995.1
proline-rich coiled-coil 2B
chr2_-_51259229 0.78 ENST00000405472.3
neurexin 1
chr16_-_11680759 0.78 ENST00000571459.1
ENST00000570798.1
ENST00000572255.1
ENST00000574763.1
ENST00000574703.1
ENST00000571277.1
ENST00000381810.3
lipopolysaccharide-induced TNF factor
chr3_-_64009102 0.78 ENST00000478185.1
ENST00000482510.1
ENST00000497323.1
ENST00000492933.1
ENST00000295901.4
proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
chr9_+_100745615 0.77 ENST00000339399.4
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr4_-_71705027 0.76 ENST00000545193.1
G-rich RNA sequence binding factor 1
chr7_-_752074 0.76 ENST00000360274.4
protein kinase, cAMP-dependent, regulatory, type I, beta
chr13_-_41345277 0.76 ENST00000323563.6
mitochondrial ribosomal protein S31
chr17_-_40428359 0.76 ENST00000293328.3
signal transducer and activator of transcription 5B
chr16_+_1128781 0.75 ENST00000293897.4
ENST00000562758.1
somatostatin receptor 5
chr9_+_100174344 0.75 ENST00000422139.2
tudor domain containing 7
chr18_+_11752040 0.75 ENST00000423027.3
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr5_+_110074685 0.74 ENST00000355943.3
ENST00000447245.2
solute carrier family 25, member 46
chr7_-_140178726 0.74 ENST00000480552.1
makorin ring finger protein 1
chr13_+_35516390 0.74 ENST00000540320.1
ENST00000400445.3
ENST00000310336.4
neurobeachin
chr11_-_66139617 0.73 ENST00000544554.1
ENST00000546034.1
solute carrier family 29 (equilibrative nucleoside transporter), member 2
chr11_-_116968987 0.72 ENST00000434315.2
ENST00000292055.4
ENST00000375288.1
ENST00000542607.1
ENST00000445177.1
ENST00000375300.1
ENST00000446921.2
SIK family kinase 3
chr20_+_60813535 0.71 ENST00000358053.2
ENST00000313733.3
ENST00000439951.2
oxysterol binding protein-like 2

Network of associatons between targets according to the STRING database.

First level regulatory network of ZIC3_ZIC4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.1 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861)
1.3 4.0 GO:0071344 diphosphate metabolic process(GO:0071344)
1.3 3.9 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
1.2 3.5 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
1.0 3.1 GO:1902997 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
1.0 5.2 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.9 2.8 GO:0021919 BMP signaling pathway involved in spinal cord dorsal/ventral patterning(GO:0021919)
0.9 2.8 GO:0051066 dihydrobiopterin metabolic process(GO:0051066)
0.8 4.2 GO:0042997 negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.8 2.3 GO:0097212 cadmium ion homeostasis(GO:0055073) lysosomal membrane organization(GO:0097212) negative regulation of hydrogen peroxide catabolic process(GO:2000296) regulation of oxygen metabolic process(GO:2000374)
0.7 2.2 GO:0042450 arginine biosynthetic process via ornithine(GO:0042450)
0.7 2.1 GO:0019858 cytosine metabolic process(GO:0019858)
0.7 2.0 GO:0070602 regulation of centromeric sister chromatid cohesion(GO:0070602)
0.6 1.8 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.6 1.2 GO:1902512 positive regulation of apoptotic DNA fragmentation(GO:1902512)
0.6 5.3 GO:0030091 protein repair(GO:0030091)
0.5 0.5 GO:0036466 synaptic vesicle recycling via endosome(GO:0036466)
0.5 11.4 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.5 2.0 GO:0014054 positive regulation of gamma-aminobutyric acid secretion(GO:0014054)
0.5 1.9 GO:1902075 cellular response to salt(GO:1902075)
0.5 3.9 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.5 2.9 GO:0016554 cytidine to uridine editing(GO:0016554)
0.5 1.9 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.5 1.4 GO:0044537 regulation of circulating fibrinogen levels(GO:0044537)
0.4 1.3 GO:2000687 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.4 4.6 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.4 1.2 GO:0006669 sphinganine-1-phosphate biosynthetic process(GO:0006669)
0.4 1.2 GO:1902995 regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995)
0.4 4.0 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.4 1.2 GO:0031938 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) regulation of chromatin silencing at telomere(GO:0031938) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.3 1.3 GO:0046101 hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101)
0.3 0.9 GO:0008050 female courtship behavior(GO:0008050) positive regulation of female receptivity(GO:0045925)
0.3 0.3 GO:0006543 glutamine catabolic process(GO:0006543)
0.3 2.1 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.3 0.3 GO:0002514 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.3 0.9 GO:2000523 dendritic cell dendrite assembly(GO:0097026) regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) regulation of dendritic cell dendrite assembly(GO:2000547)
0.3 1.1 GO:0060024 rhythmic synaptic transmission(GO:0060024)
0.3 1.1 GO:0061743 motor learning(GO:0061743)
0.3 1.7 GO:1904431 positive regulation of t-circle formation(GO:1904431)
0.3 1.9 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.3 1.1 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.2 0.7 GO:0090149 mitochondrial membrane fission(GO:0090149)
0.2 1.5 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.2 1.0 GO:0044571 [2Fe-2S] cluster assembly(GO:0044571)
0.2 1.9 GO:0044351 macropinocytosis(GO:0044351)
0.2 2.4 GO:0015939 pantothenate metabolic process(GO:0015939)
0.2 2.4 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.2 0.9 GO:0015808 L-alanine transport(GO:0015808)
0.2 1.6 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.2 2.3 GO:1904415 regulation of xenophagy(GO:1904415) positive regulation of xenophagy(GO:1904417)
0.2 1.8 GO:0017185 peptidyl-lysine hydroxylation(GO:0017185)
0.2 0.7 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
0.2 1.1 GO:0042256 mature ribosome assembly(GO:0042256)
0.2 1.5 GO:0021999 neural plate anterior/posterior regionalization(GO:0021999)
0.2 2.2 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.2 0.9 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.2 1.7 GO:0072718 response to cisplatin(GO:0072718)
0.2 0.4 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.2 1.1 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.2 1.9 GO:0042756 drinking behavior(GO:0042756)
0.2 0.6 GO:1905224 clathrin-coated pit assembly(GO:1905224)
0.2 0.9 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.2 0.9 GO:0015891 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.2 0.5 GO:0006478 peptidyl-tyrosine sulfation(GO:0006478)
0.2 4.7 GO:0007035 vacuolar acidification(GO:0007035)
0.2 1.6 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.2 2.9 GO:0038092 nodal signaling pathway(GO:0038092)
0.2 2.8 GO:0045199 maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.2 0.5 GO:0090611 mitotic cytokinesis checkpoint(GO:0044878) ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.2 0.8 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.1 4.6 GO:0003299 muscle hypertrophy in response to stress(GO:0003299) cardiac muscle adaptation(GO:0014887) cardiac muscle hypertrophy in response to stress(GO:0014898)
0.1 0.6 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
0.1 2.0 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.1 0.6 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)
0.1 2.3 GO:0000338 protein deneddylation(GO:0000338)
0.1 1.3 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713)
0.1 2.6 GO:0002021 response to dietary excess(GO:0002021)
0.1 0.5 GO:0008063 Toll signaling pathway(GO:0008063)
0.1 0.5 GO:0009212 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
0.1 0.7 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.1 0.4 GO:0000967 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
0.1 0.9 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.1 0.4 GO:0021722 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.1 0.9 GO:0006102 isocitrate metabolic process(GO:0006102)
0.1 2.3 GO:0043306 positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
0.1 0.5 GO:0002572 pro-T cell differentiation(GO:0002572)
0.1 0.8 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.1 2.0 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.1 0.9 GO:0006528 asparagine metabolic process(GO:0006528)
0.1 1.9 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 0.5 GO:0030822 positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123)
0.1 1.4 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.1 0.9 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.1 1.5 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.1 1.0 GO:0060453 regulation of gastric acid secretion(GO:0060453)
0.1 0.8 GO:0048733 sebaceous gland development(GO:0048733)
0.1 1.7 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.1 0.9 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.1 0.3 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.1 0.3 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
0.1 0.4 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.1 3.7 GO:0006536 glutamate metabolic process(GO:0006536)
0.1 0.8 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1 0.5 GO:0033489 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.1 0.4 GO:0021784 postganglionic parasympathetic fiber development(GO:0021784)
0.1 1.2 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.1 3.5 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.1 0.3 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
0.1 0.6 GO:0021853 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 1.8 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)
0.1 0.7 GO:0097033 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1 0.3 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.1 2.3 GO:0071294 cellular response to zinc ion(GO:0071294)
0.1 2.8 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.1 0.3 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.1 0.8 GO:0032494 response to peptidoglycan(GO:0032494)
0.1 0.5 GO:0006789 bilirubin conjugation(GO:0006789)
0.1 0.2 GO:1901355 response to rapamycin(GO:1901355)
0.1 1.8 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.1 1.1 GO:0030183 B cell differentiation(GO:0030183)
0.1 1.7 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 2.0 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 0.5 GO:0060174 limb bud formation(GO:0060174)
0.1 0.5 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.1 0.9 GO:0046051 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.1 0.3 GO:0001927 exocyst assembly(GO:0001927)
0.1 1.7 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 0.5 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.1 0.2 GO:0021913 glandular epithelial cell maturation(GO:0002071) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913) type B pancreatic cell maturation(GO:0072560)
0.1 0.5 GO:0070995 NADPH oxidation(GO:0070995)
0.1 0.4 GO:0052405 negative regulation by host of symbiont molecular function(GO:0052405)
0.1 0.9 GO:0006002 fructose 6-phosphate metabolic process(GO:0006002)
0.1 3.9 GO:0007602 phototransduction(GO:0007602)
0.1 0.9 GO:1901642 nucleoside transmembrane transport(GO:1901642)
0.1 0.6 GO:0007144 female meiosis I(GO:0007144)
0.1 0.8 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.1 0.5 GO:0035385 Roundabout signaling pathway(GO:0035385)
0.1 0.5 GO:0072520 seminiferous tubule development(GO:0072520)
0.0 1.1 GO:0006293 nucleotide-excision repair, preincision complex stabilization(GO:0006293) nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0 2.5 GO:0043486 histone exchange(GO:0043486)
0.0 0.9 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 1.8 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0 0.2 GO:0009957 epidermal cell fate specification(GO:0009957)
0.0 1.1 GO:0034389 lipid particle organization(GO:0034389)
0.0 1.0 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.0 0.2 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.0 0.2 GO:0070305 response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321)
0.0 0.3 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 1.7 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.0 1.2 GO:0031643 positive regulation of myelination(GO:0031643)
0.0 0.9 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 0.3 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.0 1.6 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 0.6 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 0.5 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.2 GO:0006382 adenosine to inosine editing(GO:0006382)
0.0 0.4 GO:1990403 embryonic brain development(GO:1990403)
0.0 0.1 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.3 GO:0051444 negative regulation of ubiquitin-protein transferase activity(GO:0051444)
0.0 0.1 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.0 0.0 GO:0031291 Ran protein signal transduction(GO:0031291)
0.0 0.3 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.0 0.4 GO:0007320 insemination(GO:0007320)
0.0 2.2 GO:0021762 substantia nigra development(GO:0021762)
0.0 0.1 GO:0048073 regulation of eye pigmentation(GO:0048073)
0.0 1.1 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 1.3 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 1.2 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.2 GO:0035461 vitamin transmembrane transport(GO:0035461)
0.0 3.0 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.4 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.0 0.1 GO:0000965 mitochondrial RNA 3'-end processing(GO:0000965)
0.0 0.4 GO:0006705 mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212)
0.0 0.1 GO:0072364 regulation of cellular ketone metabolic process by regulation of transcription from RNA polymerase II promoter(GO:0072364)
0.0 0.1 GO:0061046 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492) regulation of branching involved in lung morphogenesis(GO:0061046) positive regulation of branching involved in lung morphogenesis(GO:0061047)
0.0 0.5 GO:0007614 short-term memory(GO:0007614)
0.0 0.2 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 1.3 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 0.1 GO:0060120 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.0 0.7 GO:0016578 histone deubiquitination(GO:0016578)
0.0 1.5 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 1.8 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.2 GO:0046465 dolichyl diphosphate biosynthetic process(GO:0006489) dolichyl diphosphate metabolic process(GO:0046465)
0.0 0.6 GO:0035116 embryonic hindlimb morphogenesis(GO:0035116)
0.0 1.4 GO:0035722 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.0 0.1 GO:0021539 subthalamus development(GO:0021539)
0.0 0.1 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.0 0.1 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.4 GO:0001964 startle response(GO:0001964)
0.0 1.1 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.3 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.3 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.0 0.7 GO:0010165 response to X-ray(GO:0010165)
0.0 0.1 GO:0030860 regulation of polarized epithelial cell differentiation(GO:0030860)
0.0 0.5 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.0 0.6 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.1 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.0 0.0 GO:0036480 neuron intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0036480) regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903376)
0.0 0.1 GO:0071105 response to interleukin-11(GO:0071105)
0.0 0.0 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 2.6 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 0.1 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.0 3.2 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 0.4 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.0 0.6 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.2 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.2 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.0 0.1 GO:0060605 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.2 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.0 0.3 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 1.4 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0 0.2 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.4 GO:0000075 cell cycle checkpoint(GO:0000075)
0.0 0.0 GO:2000824 negative regulation of androgen receptor activity(GO:2000824)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.5 2.8 GO:0098560 cytoplasmic side of late endosome membrane(GO:0098560)
0.4 1.2 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.4 1.2 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.4 3.9 GO:0045180 basal cortex(GO:0045180)
0.4 1.8 GO:0071986 Ragulator complex(GO:0071986)
0.3 1.3 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.3 4.7 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.3 2.0 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
0.3 5.2 GO:0043020 NADPH oxidase complex(GO:0043020)
0.3 3.1 GO:0005641 nuclear envelope lumen(GO:0005641)
0.3 2.5 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.2 2.3 GO:0097449 astrocyte projection(GO:0097449)
0.2 2.3 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.2 0.9 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.2 1.9 GO:0044327 dendritic spine head(GO:0044327)
0.2 8.3 GO:0031941 filamentous actin(GO:0031941)
0.2 0.5 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.1 1.5 GO:0033391 chromatoid body(GO:0033391)
0.1 0.7 GO:0070826 paraferritin complex(GO:0070826)
0.1 3.4 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 0.4 GO:0030689 Noc complex(GO:0030689)
0.1 7.1 GO:0031904 endosome lumen(GO:0031904)
0.1 0.5 GO:1990031 pinceau fiber(GO:1990031)
0.1 0.9 GO:0036157 outer dynein arm(GO:0036157)
0.1 1.3 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.1 0.5 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.1 0.4 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 1.4 GO:0005869 dynactin complex(GO:0005869)
0.1 1.9 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 1.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.3 GO:0035189 Rb-E2F complex(GO:0035189)
0.1 1.3 GO:0044754 autolysosome(GO:0044754)
0.1 1.1 GO:0043083 synaptic cleft(GO:0043083)
0.1 1.0 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 1.8 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 0.8 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 0.5 GO:0031252 cell leading edge(GO:0031252)
0.1 2.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 2.4 GO:0005838 proteasome regulatory particle(GO:0005838)
0.1 1.5 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 2.1 GO:0031143 pseudopodium(GO:0031143)
0.1 6.7 GO:0035580 specific granule lumen(GO:0035580)
0.1 0.9 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 3.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.5 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.6 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 4.1 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.7 GO:0000124 SAGA complex(GO:0000124)
0.0 0.9 GO:0097440 apical dendrite(GO:0097440)
0.0 2.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.5 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.2 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.0 3.6 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 0.2 GO:0070876 SOSS complex(GO:0070876)
0.0 4.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.5 GO:0000815 ESCRT III complex(GO:0000815)
0.0 1.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.9 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 2.5 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 1.3 GO:0045095 keratin filament(GO:0045095)
0.0 1.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 1.2 GO:0005813 centrosome(GO:0005813)
0.0 0.2 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.2 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 1.5 GO:0000786 nucleosome(GO:0000786)
0.0 1.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 12.1 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 4.4 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 0.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.3 GO:0098589 membrane region(GO:0098589)
0.0 0.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 1.0 GO:0008021 synaptic vesicle(GO:0008021)
0.0 0.3 GO:0000145 exocyst(GO:0000145)
0.0 4.0 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 1.7 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.3 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 1.0 GO:0005882 intermediate filament(GO:0005882)
0.0 2.9 GO:0005770 late endosome(GO:0005770)
0.0 2.5 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)
0.0 0.1 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0 1.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.2 GO:0008328 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 1.2 GO:0035579 specific granule membrane(GO:0035579)
0.0 1.2 GO:0043204 perikaryon(GO:0043204)
0.0 0.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 2.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.3 GO:0042629 mast cell granule(GO:0042629)
0.0 0.3 GO:0032391 photoreceptor connecting cilium(GO:0032391)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 11.4 GO:0071933 Arp2/3 complex binding(GO:0071933)
1.4 4.2 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
1.3 3.9 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
1.2 3.6 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
1.0 4.0 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.9 6.5 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.7 3.7 GO:0047820 D-glutamate cyclase activity(GO:0047820)
0.6 2.4 GO:0004594 pantothenate kinase activity(GO:0004594)
0.6 1.7 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.6 2.8 GO:0070404 NADH binding(GO:0070404)
0.5 1.9 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.5 1.5 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.5 2.9 GO:0015185 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.4 3.9 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.4 2.5 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.4 1.3 GO:0032089 NACHT domain binding(GO:0032089)
0.4 2.9 GO:0001727 lipid kinase activity(GO:0001727)
0.4 1.2 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.3 2.1 GO:0047685 amine sulfotransferase activity(GO:0047685)
0.3 2.3 GO:0046870 cadmium ion binding(GO:0046870)
0.3 7.1 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.3 2.2 GO:0016842 amidine-lyase activity(GO:0016842)
0.3 5.2 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.3 1.0 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.2 2.4 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.2 0.9 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.2 0.9 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.2 1.6 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.2 0.7 GO:0004967 glucagon receptor activity(GO:0004967)
0.2 2.3 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.2 1.3 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.2 0.7 GO:0016781 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
0.2 0.9 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.2 3.1 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.2 0.5 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.2 0.9 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.2 4.7 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.2 3.9 GO:0002162 dystroglycan binding(GO:0002162)
0.2 0.8 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 1.9 GO:0042608 T cell receptor binding(GO:0042608)
0.1 5.0 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 0.4 GO:0033149 FFAT motif binding(GO:0033149)
0.1 0.8 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.1 0.5 GO:0019826 oxygen sensor activity(GO:0019826)
0.1 0.7 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.1 0.4 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.1 2.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 0.4 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.1 0.9 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 1.6 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 0.5 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 1.1 GO:0033592 RNA strand annealing activity(GO:0033592)
0.1 2.0 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 1.8 GO:0019992 diacylglycerol binding(GO:0019992)
0.1 2.1 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 0.3 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.1 0.7 GO:0034711 inhibin binding(GO:0034711)
0.1 1.0 GO:0097016 L27 domain binding(GO:0097016)
0.1 0.7 GO:0089720 caspase binding(GO:0089720)
0.1 0.3 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 1.1 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 1.5 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1 0.2 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.1 2.5 GO:0005123 death receptor binding(GO:0005123)
0.1 1.7 GO:0000339 RNA cap binding(GO:0000339)
0.1 1.8 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 0.4 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 1.2 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.1 1.0 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 2.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 1.9 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 3.2 GO:0042169 SH2 domain binding(GO:0042169)
0.1 1.0 GO:0032452 histone demethylase activity(GO:0032452)
0.1 0.9 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 0.5 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.1 1.0 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 1.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.9 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 2.4 GO:0050699 WW domain binding(GO:0050699)
0.1 0.5 GO:0048495 Roundabout binding(GO:0048495)
0.1 3.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 0.6 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 0.2 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.1 0.9 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 0.2 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.1 0.9 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 0.3 GO:0050145 nucleoside phosphate kinase activity(GO:0050145)
0.1 1.6 GO:0030552 cAMP binding(GO:0030552)
0.0 0.8 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.5 GO:0031996 thioesterase binding(GO:0031996)
0.0 1.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.2 GO:0097108 hedgehog family protein binding(GO:0097108)
0.0 1.6 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.6 GO:0070411 I-SMAD binding(GO:0070411)
0.0 1.2 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.9 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.8 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 1.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.2 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0 0.2 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 4.8 GO:0005262 calcium channel activity(GO:0005262)
0.0 4.5 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 1.4 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 1.1 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 1.0 GO:0031489 myosin V binding(GO:0031489)
0.0 3.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.5 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.2 GO:0003945 N-acetyllactosamine synthase activity(GO:0003945)
0.0 0.9 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 2.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.1 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.8 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 1.0 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 0.4 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 1.8 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.2 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.1 GO:0005113 patched binding(GO:0005113)
0.0 0.6 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.5 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.6 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.0 2.3 GO:0019955 cytokine binding(GO:0019955)
0.0 1.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 1.7 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.6 GO:0030332 cyclin binding(GO:0030332)
0.0 7.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 1.2 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 0.5 GO:0003682 chromatin binding(GO:0003682)
0.0 0.7 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.1 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.4 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.1 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.0 0.2 GO:0098505 single-stranded telomeric DNA binding(GO:0043047) G-rich strand telomeric DNA binding(GO:0098505)
0.0 1.0 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.6 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.4 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.1 GO:0004935 adrenergic receptor activity(GO:0004935)
0.0 0.2 GO:0005158 insulin receptor binding(GO:0005158)
0.0 1.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.1 GO:0005112 Notch binding(GO:0005112)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.8 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 6.5 PID ARF6 PATHWAY Arf6 signaling events
0.1 1.2 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 2.1 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 5.7 PID PLK1 PATHWAY PLK1 signaling events
0.1 1.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 6.6 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.1 5.5 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 1.7 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 3.0 PID IL3 PATHWAY IL3-mediated signaling events
0.1 5.5 PID RAC1 PATHWAY RAC1 signaling pathway
0.1 2.8 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 2.9 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 1.9 PID AURORA A PATHWAY Aurora A signaling
0.0 0.6 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 1.2 PID MYC PATHWAY C-MYC pathway
0.0 0.7 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.5 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 1.9 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 2.5 PID BMP PATHWAY BMP receptor signaling
0.0 3.3 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.5 PID CD40 PATHWAY CD40/CD40L signaling
0.0 5.0 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.1 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.7 PID IL27 PATHWAY IL27-mediated signaling events
0.0 1.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.7 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 1.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 1.3 PID TNF PATHWAY TNF receptor signaling pathway
0.0 0.3 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 1.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.8 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.1 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 0.5 PID INSULIN PATHWAY Insulin Pathway
0.0 0.7 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.5 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.6 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.4 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.7 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.7 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.1 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.2 3.6 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 4.0 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.2 2.4 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.2 4.2 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.2 1.1 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.1 2.1 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.1 2.4 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 2.0 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.1 5.2 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 2.6 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 3.5 REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION Genes involved in Glucagon signaling in metabolic regulation
0.1 3.0 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 2.1 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.1 1.7 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.1 2.4 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 3.0 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 1.9 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.2 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 1.8 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.9 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 1.9 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.1 4.6 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.1 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.8 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.0 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0 1.1 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.3 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.9 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 2.4 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0 1.7 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.6 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 1.6 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.4 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.9 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.8 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 0.5 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.6 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.7 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.4 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 1.6 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.3 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.5 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 1.4 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.7 REACTOME TRNA AMINOACYLATION Genes involved in tRNA Aminoacylation
0.0 0.2 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.5 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 1.2 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.9 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.4 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.3 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 1.3 REACTOME TRANS GOLGI NETWORK VESICLE BUDDING Genes involved in trans-Golgi Network Vesicle Budding
0.0 0.9 REACTOME SIGNALING BY NOTCH1 Genes involved in Signaling by NOTCH1
0.0 0.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 3.3 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 3.1 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.5 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.4 REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE Genes involved in MyD88:Mal cascade initiated on plasma membrane
0.0 1.7 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0 1.4 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 1.5 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.6 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.4 REACTOME SPHINGOLIPID METABOLISM Genes involved in Sphingolipid metabolism
0.0 0.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.2 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.8 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.3 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules