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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for ZKSCAN1

Z-value: 0.88

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Transcription factors associated with ZKSCAN1

Gene Symbol Gene ID Gene Info
ZKSCAN1
ENSG00000106261.12 zinc finger with KRAB and SCAN domains 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZKSCAN1hg19_v2_chr7_+_99613212_99613236-0.135.6e-02Click!

Activity profile of ZKSCAN1 motif

Sorted Z-values of ZKSCAN1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_135394840 53.79 ENST00000503087.1
TGFBI
transforming growth factor, beta-induced, 68kDa
chr22_+_21921994 36.03 ENST00000545681.1
UBE2L3
ubiquitin-conjugating enzyme E2L 3
chr17_-_73150599 35.79 ENST00000392566.2
ENST00000581874.1
HN1
hematological and neurological expressed 1
chr17_-_73150629 29.32 ENST00000356033.4
ENST00000405458.3
ENST00000409753.3
HN1
hematological and neurological expressed 1
chrX_+_47441712 24.65 ENST00000218388.4
ENST00000377018.2
ENST00000456754.2
ENST00000377017.1
ENST00000441738.1
TIMP1
TIMP metallopeptidase inhibitor 1
chr19_+_39138320 22.22 ENST00000424234.2
ENST00000390009.3
ENST00000589528.1
ACTN4
actinin, alpha 4
chr5_-_134735568 21.78 ENST00000510038.1
ENST00000304332.4
H2AFY
H2A histone family, member Y
chr22_-_37640277 20.38 ENST00000401529.3
ENST00000249071.6
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr20_-_48770244 20.00 ENST00000371650.5
ENST00000371652.4
ENST00000557021.1
TMEM189
transmembrane protein 189
chr19_+_13051206 19.55 ENST00000586760.1
CALR
calreticulin
chr11_-_58343319 18.87 ENST00000395074.2
LPXN
leupaxin
chr1_+_62901968 18.41 ENST00000452143.1
ENST00000442679.1
ENST00000371146.1
USP1
ubiquitin specific peptidase 1
chr1_-_53704157 17.19 ENST00000371466.4
ENST00000371470.3
MAGOH
mago-nashi homolog, proliferation-associated (Drosophila)
chr15_-_69113218 16.41 ENST00000560303.1
ENST00000465139.2
ANP32A
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr19_+_39138271 15.19 ENST00000252699.2
ACTN4
actinin, alpha 4
chr15_-_34635314 14.60 ENST00000557912.1
ENST00000328848.4
NOP10
NOP10 ribonucleoprotein
chr22_-_37640456 14.22 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr11_+_64808675 13.71 ENST00000529996.1
SAC3D1
SAC3 domain containing 1
chr3_+_184081213 13.20 ENST00000429568.1
POLR2H
polymerase (RNA) II (DNA directed) polypeptide H
chr3_+_184081175 13.06 ENST00000452961.1
ENST00000296223.3
POLR2H
polymerase (RNA) II (DNA directed) polypeptide H
chr17_+_75372165 12.16 ENST00000427674.2
SEPT9
septin 9
chr9_-_139357413 11.87 ENST00000277537.6
SEC16A
SEC16 homolog A (S. cerevisiae)
chr11_+_70049269 11.53 ENST00000301838.4
FADD
Fas (TNFRSF6)-associated via death domain
chr3_+_184081137 10.96 ENST00000443489.1
POLR2H
polymerase (RNA) II (DNA directed) polypeptide H
chr7_+_73588575 10.95 ENST00000265753.8
EIF4H
eukaryotic translation initiation factor 4H
chr11_+_32112431 10.40 ENST00000054950.3
RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr11_-_72070206 10.28 ENST00000544382.1
CLPB
ClpB caseinolytic peptidase B homolog (E. coli)
chr5_-_134734901 9.83 ENST00000312469.4
ENST00000423969.2
H2AFY
H2A histone family, member Y
chr19_-_19051993 9.55 ENST00000594794.1
ENST00000355887.6
ENST00000392351.3
ENST00000596482.1
HOMER3
homer homolog 3 (Drosophila)
chr1_+_65613340 9.20 ENST00000546702.1
AK4
adenylate kinase 4
chr10_-_88281494 8.87 ENST00000298767.5
WAPAL
wings apart-like homolog (Drosophila)
chr8_-_131028869 8.62 ENST00000518283.1
ENST00000519110.1
FAM49B
family with sequence similarity 49, member B
chr7_+_73588665 8.58 ENST00000353999.6
EIF4H
eukaryotic translation initiation factor 4H
chr2_-_158345462 8.24 ENST00000439355.1
ENST00000540637.1
CYTIP
cytohesin 1 interacting protein
chr19_-_55660561 8.23 ENST00000587758.1
ENST00000356783.5
ENST00000291901.8
ENST00000588426.1
ENST00000588147.1
ENST00000536926.1
ENST00000588981.1
TNNT1
troponin T type 1 (skeletal, slow)
chr5_-_131562935 7.81 ENST00000379104.2
ENST00000379100.2
ENST00000428369.1
P4HA2
prolyl 4-hydroxylase, alpha polypeptide II
chr5_-_172756506 7.50 ENST00000265087.4
STC2
stanniocalcin 2
chr6_+_32944119 6.58 ENST00000606059.1
BRD2
bromodomain containing 2
chr3_+_63898275 6.56 ENST00000538065.1
ATXN7
ataxin 7
chr17_+_27071002 6.38 ENST00000262395.5
ENST00000422344.1
ENST00000444415.3
ENST00000262396.6
TRAF4
TNF receptor-associated factor 4
chr12_+_122326662 6.33 ENST00000261817.2
ENST00000538613.1
ENST00000542602.1
PSMD9
proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
chr12_+_4385230 6.23 ENST00000536537.1
CCND2
cyclin D2
chr9_-_112260531 6.13 ENST00000374541.2
ENST00000262539.3
PTPN3
protein tyrosine phosphatase, non-receptor type 3
chr20_+_43343517 6.07 ENST00000372865.4
WISP2
WNT1 inducible signaling pathway protein 2
chr12_-_49319265 5.96 ENST00000552878.1
ENST00000453172.2
FKBP11
FK506 binding protein 11, 19 kDa
chr1_-_36615051 5.77 ENST00000373163.1
TRAPPC3
trafficking protein particle complex 3
chr1_-_155224751 5.36 ENST00000350210.2
ENST00000368368.3
FAM189B
family with sequence similarity 189, member B
chrX_+_109245863 5.32 ENST00000372072.3
TMEM164
transmembrane protein 164
chr1_+_236958554 5.24 ENST00000366577.5
ENST00000418145.2
MTR
5-methyltetrahydrofolate-homocysteine methyltransferase
chr20_+_43343476 5.18 ENST00000372868.2
WISP2
WNT1 inducible signaling pathway protein 2
chr12_+_122326630 5.14 ENST00000541212.1
ENST00000340175.5
PSMD9
proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
chr1_-_36615065 4.97 ENST00000373166.3
ENST00000373159.1
ENST00000373162.1
TRAPPC3
trafficking protein particle complex 3
chr5_-_127873659 4.70 ENST00000262464.4
FBN2
fibrillin 2
chr6_-_30640811 4.63 ENST00000376442.3
DHX16
DEAH (Asp-Glu-Ala-His) box polypeptide 16
chr19_-_3062881 4.63 ENST00000586742.1
AES
amino-terminal enhancer of split
chr10_+_112679301 4.55 ENST00000265277.5
ENST00000369452.4
SHOC2
soc-2 suppressor of clear homolog (C. elegans)
chr15_-_78369994 4.35 ENST00000300584.3
ENST00000409931.3
TBC1D2B
TBC1 domain family, member 2B
chr15_-_37390482 4.29 ENST00000559085.1
ENST00000397624.3
MEIS2
Meis homeobox 2
chr2_+_101179152 4.27 ENST00000264254.6
PDCL3
phosducin-like 3
chr19_-_3063099 4.09 ENST00000221561.8
AES
amino-terminal enhancer of split
chr10_-_112678904 4.00 ENST00000423273.1
ENST00000436562.1
ENST00000447005.1
ENST00000454061.1
BBIP1
BBSome interacting protein 1
chr3_+_12329397 3.88 ENST00000397015.2
PPARG
peroxisome proliferator-activated receptor gamma
chr10_-_112678692 3.82 ENST00000605742.1
BBIP1
BBSome interacting protein 1
chr19_-_3062465 3.61 ENST00000327141.4
AES
amino-terminal enhancer of split
chr12_-_25055177 3.34 ENST00000538118.1
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr3_+_12329358 3.31 ENST00000309576.6
PPARG
peroxisome proliferator-activated receptor gamma
chrX_-_40036520 3.25 ENST00000406200.2
ENST00000378455.4
ENST00000342274.4
BCOR
BCL6 corepressor
chr22_+_20861858 2.98 ENST00000414658.1
ENST00000432052.1
ENST00000425759.2
ENST00000292733.7
ENST00000542773.1
ENST00000263205.7
ENST00000406969.1
ENST00000382974.2
MED15
mediator complex subunit 15
chr19_+_51630287 2.97 ENST00000599948.1
SIGLEC9
sialic acid binding Ig-like lectin 9
chr15_+_75494214 2.85 ENST00000394987.4
C15orf39
chromosome 15 open reading frame 39
chr1_+_65613217 2.80 ENST00000545314.1
AK4
adenylate kinase 4
chr4_+_41540160 2.78 ENST00000503057.1
ENST00000511496.1
LIMCH1
LIM and calponin homology domains 1
chr1_+_16370271 2.56 ENST00000375679.4
CLCNKB
chloride channel, voltage-sensitive Kb
chr3_+_179322481 2.49 ENST00000259037.3
NDUFB5
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
chr1_+_16348497 2.47 ENST00000439316.2
CLCNKA
chloride channel, voltage-sensitive Ka
chr1_-_149908217 2.46 ENST00000369140.3
MTMR11
myotubularin related protein 11
chr16_+_67562702 2.43 ENST00000379312.3
ENST00000042381.4
ENST00000540839.3
FAM65A
family with sequence similarity 65, member A
chr3_+_51663407 2.28 ENST00000432863.1
ENST00000296477.3
RAD54L2
RAD54-like 2 (S. cerevisiae)
chr1_-_151804314 2.26 ENST00000318247.6
RORC
RAR-related orphan receptor C
chr15_+_40731920 2.11 ENST00000561234.1
BAHD1
bromo adjacent homology domain containing 1
chr11_+_33563821 2.01 ENST00000321505.4
ENST00000265654.5
ENST00000389726.3
KIAA1549L
KIAA1549-like
chr16_+_8736232 1.89 ENST00000562973.1
METTL22
methyltransferase like 22
chr11_+_46366918 1.75 ENST00000528615.1
ENST00000395574.3
DGKZ
diacylglycerol kinase, zeta
chr16_-_11370330 1.67 ENST00000241808.4
ENST00000435245.2
PRM2
protamine 2
chr1_+_16348366 1.61 ENST00000375692.1
ENST00000420078.1
CLCNKA
chloride channel, voltage-sensitive Ka
chr1_-_151804222 1.49 ENST00000392697.3
RORC
RAR-related orphan receptor C
chr10_+_118350468 1.41 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
PNLIPRP1
pancreatic lipase-related protein 1
chr10_+_118350522 1.34 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
PNLIPRP1
pancreatic lipase-related protein 1
chr10_+_23384435 1.34 ENST00000376510.3
MSRB2
methionine sulfoxide reductase B2
chr19_+_13135731 1.32 ENST00000587260.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr6_+_35265586 1.19 ENST00000542066.1
ENST00000316637.5
DEF6
differentially expressed in FDCP 6 homolog (mouse)
chr20_-_62199427 1.07 ENST00000427522.2
HELZ2
helicase with zinc finger 2, transcriptional coactivator
chr19_+_13135790 0.96 ENST00000358552.3
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr20_+_44098385 0.76 ENST00000217425.5
ENST00000339946.3
WFDC2
WAP four-disulfide core domain 2
chr17_-_26684473 0.69 ENST00000540200.1
POLDIP2
polymerase (DNA-directed), delta interacting protein 2
chr10_+_89420706 0.62 ENST00000427144.2
PAPSS2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr15_+_75498739 0.40 ENST00000565074.1
C15orf39
chromosome 15 open reading frame 39
chr16_+_56899114 0.33 ENST00000566786.1
ENST00000438926.2
ENST00000563236.1
ENST00000262502.5
SLC12A3
solute carrier family 12 (sodium/chloride transporter), member 3
chr5_+_155753745 0.11 ENST00000435422.3
ENST00000337851.4
ENST00000447401.1
SGCD
sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
chr2_+_1488435 0.03 ENST00000446278.1
ENST00000469607.1
TPO
thyroid peroxidase
chr10_-_76859247 0.01 ENST00000472493.2
ENST00000605915.1
ENST00000478873.2
DUSP13
dual specificity phosphatase 13

Network of associatons between targets according to the STRING database.

First level regulatory network of ZKSCAN1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
12.5 37.4 GO:1902396 protein localization to bicellular tight junction(GO:1902396)
10.5 31.6 GO:1901837 positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184) negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837) negative regulation of protein localization to chromosome, telomeric region(GO:1904815)
5.5 44.2 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
4.9 19.5 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
3.1 34.6 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
2.9 14.6 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
2.9 11.5 GO:0072683 T cell extravasation(GO:0072683)
2.4 18.9 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
2.3 11.5 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
2.0 12.0 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
1.8 7.2 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
1.5 18.4 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
1.4 8.6 GO:2000568 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
1.1 12.3 GO:2000210 positive regulation of anoikis(GO:2000210)
1.1 3.2 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
1.1 4.3 GO:0008616 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.9 8.2 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.8 37.2 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.8 36.0 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.6 6.1 GO:0098902 regulation of membrane depolarization during action potential(GO:0098902)
0.6 6.6 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.6 4.7 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.6 3.3 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.6 12.2 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.5 6.4 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.5 4.7 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.5 7.8 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.4 9.5 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.4 51.4 GO:0002062 chondrocyte differentiation(GO:0002062)
0.3 6.2 GO:0071481 cellular response to X-ray(GO:0071481)
0.3 16.4 GO:0043486 histone exchange(GO:0043486)
0.3 5.2 GO:0009086 methionine biosynthetic process(GO:0009086)
0.3 17.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.2 22.6 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.2 2.3 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.2 3.7 GO:0060850 regulation of transcription involved in cell fate commitment(GO:0060850)
0.2 2.1 GO:0031507 heterochromatin assembly(GO:0031507)
0.2 0.6 GO:0000103 sulfate assimilation(GO:0000103)
0.1 1.3 GO:0030091 protein repair(GO:0030091)
0.1 6.6 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.1 1.8 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.1 6.6 GO:0006334 nucleosome assembly(GO:0006334)
0.1 4.6 GO:0046579 positive regulation of Ras protein signal transduction(GO:0046579)
0.1 4.3 GO:1902017 regulation of cilium assembly(GO:1902017)
0.1 4.3 GO:0008542 visual learning(GO:0008542)
0.1 10.3 GO:0034605 cellular response to heat(GO:0034605)
0.0 1.7 GO:0030261 chromosome condensation(GO:0030261)
0.0 2.5 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.7 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.0 10.4 GO:0001701 in utero embryonic development(GO:0001701)
0.0 1.9 GO:0018022 peptidyl-lysine methylation(GO:0018022)
0.0 3.0 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 7.6 GO:0051301 cell division(GO:0051301)
0.0 7.7 GO:0016567 protein ubiquitination(GO:0016567)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.3 31.6 GO:0001740 Barr body(GO:0001740)
2.4 19.6 GO:0042824 MHC class I peptide loading complex(GO:0042824)
2.4 14.6 GO:0090661 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
2.1 37.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
1.3 37.4 GO:0031143 pseudopodium(GO:0031143)
1.0 6.2 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.9 10.7 GO:0030008 TRAPP complex(GO:0030008)
0.9 19.5 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.6 11.5 GO:0097342 ripoptosome(GO:0097342)
0.6 17.2 GO:0035145 exon-exon junction complex(GO:0035145)
0.6 11.5 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.6 73.9 GO:0005604 basement membrane(GO:0005604)
0.6 12.2 GO:0031105 septin complex(GO:0031105)
0.4 34.6 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.3 8.2 GO:0005861 troponin complex(GO:0005861)
0.3 18.9 GO:0002102 podosome(GO:0002102)
0.3 4.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.3 2.3 GO:0034464 BBSome(GO:0034464)
0.2 4.7 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.2 2.1 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 9.5 GO:0045178 basal part of cell(GO:0045178)
0.1 3.0 GO:0016592 mediator complex(GO:0016592)
0.1 36.0 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.1 6.6 GO:0034707 chloride channel complex(GO:0034707)
0.1 23.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 8.6 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 3.2 GO:0031519 PcG protein complex(GO:0031519)
0.0 6.6 GO:0016363 nuclear matrix(GO:0016363)
0.0 13.7 GO:0005819 spindle(GO:0005819)
0.0 7.2 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 2.5 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.7 GO:0000786 nucleosome(GO:0000786)
0.0 6.7 GO:0005938 cell cortex(GO:0005938)
0.0 6.1 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 4.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 6.8 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.1 GO:0016012 dystroglycan complex(GO:0016011) sarcoglycan complex(GO:0016012)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 19.5 GO:0034057 RNA strand-exchange activity(GO:0034057)
3.5 31.6 GO:0000182 rDNA binding(GO:0000182)
3.0 36.0 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
3.0 12.0 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
2.4 19.6 GO:0001849 complement component C1q binding(GO:0001849)
2.4 14.6 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
2.1 37.2 GO:0001054 RNA polymerase I activity(GO:0001054)
1.6 7.8 GO:0019798 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
1.4 8.6 GO:0023025 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
1.3 11.5 GO:0035877 death effector domain binding(GO:0035877)
0.9 44.6 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.9 4.3 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.8 20.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.8 53.8 GO:0050840 extracellular matrix binding(GO:0050840)
0.7 5.2 GO:0008172 S-methyltransferase activity(GO:0008172)
0.6 9.5 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.6 8.2 GO:0031014 troponin T binding(GO:0031014)
0.6 4.7 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.6 3.3 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.5 3.7 GO:0008142 oxysterol binding(GO:0008142)
0.4 6.4 GO:0031996 thioesterase binding(GO:0031996)
0.4 11.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.3 1.3 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.3 6.6 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.2 22.4 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.2 0.6 GO:0004781 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.2 10.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 11.5 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.2 6.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.2 4.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 1.7 GO:0046870 cadmium ion binding(GO:0046870)
0.1 33.2 GO:0019887 protein kinase regulator activity(GO:0019887)
0.1 6.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 2.7 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 1.8 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 16.4 GO:0042393 histone binding(GO:0042393)
0.1 20.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 18.8 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 4.6 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 7.5 GO:0005179 hormone activity(GO:0005179)
0.1 21.8 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 2.5 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.9 GO:0016278 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.0 2.1 GO:0000976 transcription regulatory region sequence-specific DNA binding(GO:0000976)
0.0 2.3 GO:0004386 helicase activity(GO:0004386)
0.0 4.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 11.2 GO:0045296 cadherin binding(GO:0045296)
0.0 0.3 GO:0015377 cation:chloride symporter activity(GO:0015377)
0.0 5.0 GO:0016887 ATPase activity(GO:0016887)
0.0 3.0 GO:0030246 carbohydrate binding(GO:0030246)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 53.8 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.7 36.0 PID BARD1 PATHWAY BARD1 signaling events
0.5 29.9 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.5 18.4 PID FANCONI PATHWAY Fanconi anemia pathway
0.4 24.7 PID IL6 7 PATHWAY IL6-mediated signaling events
0.3 31.6 PID ATF2 PATHWAY ATF-2 transcription factor network
0.3 11.5 PID TRAIL PATHWAY TRAIL signaling pathway
0.3 6.2 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.2 7.2 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.2 36.5 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.2 12.3 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.2 16.4 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 6.4 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 6.6 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 3.2 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.1 15.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 3.0 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.2 PID RAC1 REG PATHWAY Regulation of RAC1 activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 37.2 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
1.4 18.4 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
1.4 19.6 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
1.2 37.4 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.8 34.6 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.7 11.5 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.6 23.6 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.6 53.8 REACTOME AMYLOIDS Genes involved in Amyloids
0.2 17.2 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.2 27.9 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.2 19.5 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.2 36.0 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 5.2 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 3.3 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 10.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 8.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 6.2 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 3.0 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 2.5 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.6 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules