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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for ZKSCAN3

Z-value: 0.94

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Transcription factors associated with ZKSCAN3

Gene Symbol Gene ID Gene Info
ZKSCAN3
ENSG00000189298.9 zinc finger with KRAB and SCAN domains 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZKSCAN3hg19_v2_chr6_+_28317685_28317761-0.464.9e-13Click!

Activity profile of ZKSCAN3 motif

Sorted Z-values of ZKSCAN3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_64013288 26.49 ENST00000542235.1
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr11_-_64013663 22.89 ENST00000392210.2
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr15_+_41624892 13.13 ENST00000260359.6
ENST00000450318.1
ENST00000450592.2
ENST00000559596.1
ENST00000414849.2
ENST00000560747.1
ENST00000560177.1
NUSAP1
nucleolar and spindle associated protein 1
chr15_-_41624685 8.93 ENST00000560640.1
ENST00000220514.3
OIP5
Opa interacting protein 5
chr2_+_191745560 7.41 ENST00000338435.4
GLS
glutaminase
chr16_-_28506840 6.71 ENST00000569430.1
CLN3
ceroid-lipofuscinosis, neuronal 3
chr17_+_18625336 6.14 ENST00000395671.4
ENST00000571542.1
ENST00000395672.2
ENST00000414850.2
ENST00000424146.2
TRIM16L
tripartite motif containing 16-like
chr12_+_109535373 6.12 ENST00000242576.2
UNG
uracil-DNA glycosylase
chr12_+_109535923 5.91 ENST00000336865.2
UNG
uracil-DNA glycosylase
chr6_-_31508304 5.85 ENST00000376177.2
DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr1_-_19811132 5.00 ENST00000433834.1
CAPZB
capping protein (actin filament) muscle Z-line, beta
chr17_+_36908984 4.54 ENST00000225426.4
ENST00000579088.1
PSMB3
proteasome (prosome, macropain) subunit, beta type, 3
chr1_-_115259337 4.39 ENST00000369535.4
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chrX_-_153775426 4.32 ENST00000393562.2
G6PD
glucose-6-phosphate dehydrogenase
chr1_+_93913713 3.27 ENST00000604705.1
ENST00000370253.2
FNBP1L
formin binding protein 1-like
chr1_+_93913665 3.00 ENST00000271234.7
ENST00000370256.4
ENST00000260506.8
FNBP1L
formin binding protein 1-like
chr6_+_32936353 2.81 ENST00000374825.4
BRD2
bromodomain containing 2
chr12_+_100867694 2.52 ENST00000392986.3
ENST00000549996.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr7_+_155089486 2.47 ENST00000340368.4
ENST00000344756.4
ENST00000425172.1
ENST00000342407.5
INSIG1
insulin induced gene 1
chr1_-_19811996 2.38 ENST00000264203.3
ENST00000401084.2
CAPZB
capping protein (actin filament) muscle Z-line, beta
chr12_+_100867486 2.26 ENST00000548884.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr17_-_60142609 2.24 ENST00000397786.2
MED13
mediator complex subunit 13
chr22_+_50312379 2.19 ENST00000407217.3
ENST00000403427.3
CRELD2
cysteine-rich with EGF-like domains 2
chr7_+_155090271 2.18 ENST00000476756.1
INSIG1
insulin induced gene 1
chr1_+_226250379 2.09 ENST00000366815.3
ENST00000366814.3
H3F3A
H3 histone, family 3A
chr19_-_49258606 1.84 ENST00000310160.3
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr10_+_21823079 1.82 ENST00000377100.3
ENST00000377072.3
ENST00000446906.2
MLLT10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr1_-_19811962 1.61 ENST00000375142.1
ENST00000264202.6
CAPZB
capping protein (actin filament) muscle Z-line, beta
chr15_+_74610894 1.52 ENST00000558821.1
ENST00000268082.4
CCDC33
coiled-coil domain containing 33
chr10_+_123922941 1.32 ENST00000360561.3
TACC2
transforming, acidic coiled-coil containing protein 2
chr22_+_50312316 1.22 ENST00000328268.4
CRELD2
cysteine-rich with EGF-like domains 2
chr22_+_50312274 1.14 ENST00000404488.3
CRELD2
cysteine-rich with EGF-like domains 2
chrX_-_135338503 1.06 ENST00000370663.5
MAP7D3
MAP7 domain containing 3
chr10_+_21823243 1.03 ENST00000307729.7
ENST00000377091.2
MLLT10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr8_+_123793633 0.49 ENST00000314393.4
ZHX2
zinc fingers and homeoboxes 2
chr17_+_32597232 0.40 ENST00000378569.2
ENST00000200307.4
ENST00000394627.1
ENST00000394630.3
CCL7
chemokine (C-C motif) ligand 7
chr11_+_66610883 0.22 ENST00000309657.3
ENST00000524506.1
RCE1
Ras converting CAAX endopeptidase 1
chr14_-_80697396 0.18 ENST00000557010.1
DIO2
deiodinase, iodothyronine, type II

Network of associatons between targets according to the STRING database.

First level regulatory network of ZKSCAN3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 9.0 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
1.7 6.7 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
1.6 4.8 GO:1903314 nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
1.6 4.7 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
1.4 4.3 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
1.2 5.9 GO:0006543 glutamine catabolic process(GO:0006543)
0.9 12.0 GO:0045008 depyrimidination(GO:0045008)
0.9 13.1 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.6 5.8 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.5 2.1 GO:0060623 regulation of chromosome condensation(GO:0060623)
0.4 6.3 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.3 8.9 GO:0034080 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.2 1.8 GO:0019317 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.1 4.4 GO:0072600 establishment of protein localization to Golgi(GO:0072600)
0.1 0.4 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.1 2.2 GO:0070328 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.0 4.5 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 45.0 GO:0045087 innate immune response(GO:0045087)
0.0 2.8 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.2 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 1.1 GO:0046785 microtubule polymerization(GO:0046785)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 9.0 GO:0071203 WASH complex(GO:0071203)
1.2 4.7 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.5 5.8 GO:0005688 U6 snRNP(GO:0005688)
0.4 8.9 GO:0010369 chromocenter(GO:0010369)
0.3 2.1 GO:0001740 Barr body(GO:0001740)
0.3 4.5 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.2 13.1 GO:0005876 spindle microtubule(GO:0005876)
0.1 4.8 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 6.7 GO:0005776 autophagosome(GO:0005776)
0.1 2.2 GO:0016592 mediator complex(GO:0016592)
0.0 4.4 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 5.9 GO:0005759 mitochondrial matrix(GO:0005759)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:1902122 chenodeoxycholic acid binding(GO:1902122)
1.5 12.0 GO:0097506 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
1.4 4.3 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
1.2 5.9 GO:0004359 glutaminase activity(GO:0004359)
1.1 49.4 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.8 5.8 GO:0030621 U4 snRNA binding(GO:0030621)
0.2 4.5 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 2.2 GO:0042809 vitamin D receptor binding(GO:0042809)
0.1 1.8 GO:0008417 fucosyltransferase activity(GO:0008417)
0.1 2.8 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 0.4 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.0 2.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 14.2 GO:0008017 microtubule binding(GO:0008017)
0.0 6.7 GO:0051082 unfolded protein binding(GO:0051082)
0.0 9.0 GO:0051015 actin filament binding(GO:0051015)
0.0 0.2 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 6.3 GO:0051020 GTPase binding(GO:0051020)
0.0 4.4 GO:0003924 GTPase activity(GO:0003924)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 49.4 PID ILK PATHWAY Integrin-linked kinase signaling
0.2 4.4 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 4.8 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 2.8 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 4.5 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.4 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.2 5.9 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 8.9 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 2.1 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 4.5 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)