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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ZNF148
Z-value: 0.07
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Transcription factors associated with ZNF148
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF148 | hg19_v2_chr3_-_125094093_125094198 | -0.04 | 5.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF148
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 28.5 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 1.8 | 19.7 | GO:2000580 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 3.2 | 19.4 | GO:0048549 | positive regulation of pinocytosis(GO:0048549) |
| 1.0 | 19.2 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
| 0.1 | 17.2 | GO:0030705 | cytoskeleton-dependent intracellular transport(GO:0030705) |
| 0.5 | 16.0 | GO:1900273 | positive regulation of long-term synaptic potentiation(GO:1900273) |
| 0.6 | 14.5 | GO:0047497 | establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497) |
| 2.3 | 13.8 | GO:0030421 | defecation(GO:0030421) |
| 0.1 | 13.4 | GO:0043401 | steroid hormone mediated signaling pathway(GO:0043401) |
| 1.9 | 13.0 | GO:0006880 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 37.1 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.2 | 29.8 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.2 | 27.6 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 20.8 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.7 | 19.7 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.1 | 17.4 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 1.1 | 16.9 | GO:0033643 | host cell part(GO:0033643) |
| 0.3 | 16.7 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 1.3 | 16.0 | GO:0044327 | dendritic spine head(GO:0044327) |
| 3.3 | 13.0 | GO:0070288 | intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 40.9 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 20.9 | GO:0002020 | protease binding(GO:0002020) |
| 0.1 | 19.6 | GO:0005496 | steroid binding(GO:0005496) |
| 1.2 | 19.4 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.1 | 17.4 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.7 | 16.0 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
| 0.1 | 14.3 | GO:0008017 | microtubule binding(GO:0008017) |
| 1.4 | 13.0 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.7 | 12.6 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.2 | 9.9 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 35.6 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.2 | 19.0 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 12.6 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 9.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.2 | 8.2 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.2 | 7.6 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 7.2 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.2 | 6.6 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 6.3 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.1 | 6.2 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 26.1 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.6 | 16.7 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.2 | 16.4 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.1 | 15.0 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.4 | 13.3 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.4 | 11.1 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.2 | 11.1 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.2 | 9.1 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.2 | 9.0 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.3 | 8.7 | REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |