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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for ZNF232

Z-value: 1.04

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Transcription factors associated with ZNF232

Gene Symbol Gene ID Gene Info
ZNF232
ENSG00000167840.9 zinc finger protein 232

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF232hg19_v2_chr17_-_5015129_5015187-0.414.6e-10Click!

Activity profile of ZNF232 motif

Sorted Z-values of ZNF232 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_88450612 33.23 ENST00000418378.1
ENST00000282470.6
SPARCL1
SPARC-like 1 (hevin)
chr3_+_127634069 23.62 ENST00000405109.1
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr15_-_60771128 20.93 ENST00000558512.1
ENST00000561114.1
NARG2
NMDA receptor regulated 2
chr3_+_40566369 14.87 ENST00000403205.2
ENST00000310898.1
ENST00000339296.5
ENST00000431278.1
ZNF621
zinc finger protein 621
chr7_+_142829162 9.67 ENST00000291009.3
PIP
prolactin-induced protein
chr14_-_21516590 8.21 ENST00000555026.1
NDRG2
NDRG family member 2
chr3_-_185216811 8.02 ENST00000421852.1
TMEM41A
transmembrane protein 41A
chr17_-_6915646 6.71 ENST00000574377.1
ENST00000399541.2
ENST00000399540.2
ENST00000575727.1
ENST00000573939.1
AC027763.2
Uncharacterized protein
chr6_+_109416313 6.51 ENST00000521277.1
ENST00000517392.1
ENST00000407272.1
ENST00000336977.4
ENST00000519286.1
ENST00000518329.1
ENST00000522461.1
ENST00000518853.1
CEP57L1
centrosomal protein 57kDa-like 1
chr16_-_4852915 6.45 ENST00000322048.7
ROGDI
rogdi homolog (Drosophila)
chr9_-_115480303 6.33 ENST00000374234.1
ENST00000374238.1
ENST00000374236.1
ENST00000374242.4
INIP
INTS3 and NABP interacting protein
chr3_-_185216766 6.17 ENST00000296254.3
TMEM41A
transmembrane protein 41A
chr2_-_113522177 6.13 ENST00000541405.1
CKAP2L
cytoskeleton associated protein 2-like
chr8_-_143999259 5.43 ENST00000323110.2
CYP11B2
cytochrome P450, family 11, subfamily B, polypeptide 2
chr6_-_46922659 5.30 ENST00000265417.7
GPR116
G protein-coupled receptor 116
chrY_+_15016013 5.01 ENST00000360160.4
ENST00000454054.1
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
chr1_-_153029980 4.99 ENST00000392653.2
SPRR2A
small proline-rich protein 2A
chr3_+_8543561 4.84 ENST00000397386.3
LMCD1
LIM and cysteine-rich domains 1
chr5_+_177435986 4.83 ENST00000398106.2
FAM153C
family with sequence similarity 153, member C
chr3_+_8543533 4.69 ENST00000454244.1
LMCD1
LIM and cysteine-rich domains 1
chr4_+_96761238 4.53 ENST00000295266.4
PDHA2
pyruvate dehydrogenase (lipoamide) alpha 2
chr1_-_79472365 4.51 ENST00000370742.3
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr20_+_4129426 4.40 ENST00000339123.6
ENST00000305958.4
ENST00000278795.3
SMOX
spermine oxidase
chr5_-_180076580 3.83 ENST00000502649.1
FLT4
fms-related tyrosine kinase 4
chr2_-_113522248 3.77 ENST00000302450.6
CKAP2L
cytoskeleton associated protein 2-like
chr14_-_24711865 3.74 ENST00000399423.4
ENST00000267415.7
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr14_-_24711806 3.74 ENST00000540705.1
ENST00000538777.1
ENST00000558566.1
ENST00000559019.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chrX_+_100805496 3.73 ENST00000372829.3
ARMCX1
armadillo repeat containing, X-linked 1
chrX_-_130423386 3.51 ENST00000370903.3
IGSF1
immunoglobulin superfamily, member 1
chr18_+_61637159 3.45 ENST00000397985.2
ENST00000353706.2
ENST00000542677.1
ENST00000397988.3
ENST00000448851.1
SERPINB8
serpin peptidase inhibitor, clade B (ovalbumin), member 8
chr10_-_27389392 3.37 ENST00000376087.4
ANKRD26
ankyrin repeat domain 26
chr11_+_66276550 3.18 ENST00000419755.3
CTD-3074O7.11
Bardet-Biedl syndrome 1 protein
chr9_+_5231413 2.61 ENST00000239316.4
INSL4
insulin-like 4 (placenta)
chr7_-_83278322 2.59 ENST00000307792.3
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr10_-_115904361 2.42 ENST00000428953.1
ENST00000543782.1
C10orf118
chromosome 10 open reading frame 118
chr15_-_79383102 2.39 ENST00000558480.2
ENST00000419573.3
RASGRF1
Ras protein-specific guanine nucleotide-releasing factor 1
chr10_-_61900762 2.37 ENST00000355288.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr1_+_182419261 2.28 ENST00000294854.8
ENST00000542961.1
RGSL1
regulator of G-protein signaling like 1
chr17_-_3301704 2.21 ENST00000322608.2
OR1E1
olfactory receptor, family 1, subfamily E, member 1
chr17_+_26800648 2.05 ENST00000545060.1
SLC13A2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr1_-_204654826 1.92 ENST00000367177.3
LRRN2
leucine rich repeat neuronal 2
chr2_+_241807870 1.91 ENST00000307503.3
AGXT
alanine-glyoxylate aminotransferase
chr14_-_107131560 1.82 ENST00000390632.2
IGHV3-66
immunoglobulin heavy variable 3-66
chr9_+_117085336 1.77 ENST00000259396.8
ENST00000538816.1
ORM1
orosomucoid 1
chr17_+_26800296 1.72 ENST00000444914.3
ENST00000314669.5
SLC13A2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr15_-_74374891 1.68 ENST00000290438.3
GOLGA6A
golgin A6 family, member A
chr17_+_26800756 1.66 ENST00000537681.1
SLC13A2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr15_-_56757329 1.64 ENST00000260453.3
MNS1
meiosis-specific nuclear structural 1
chr16_+_30662184 1.58 ENST00000300835.4
PRR14
proline rich 14
chr1_-_160549235 1.56 ENST00000368054.3
ENST00000368048.3
ENST00000311224.4
ENST00000368051.3
ENST00000534968.1
CD84
CD84 molecule
chr13_+_27825706 1.52 ENST00000272274.4
ENST00000319826.4
ENST00000326092.4
RPL21
ribosomal protein L21
chr2_-_31637560 1.29 ENST00000379416.3
XDH
xanthine dehydrogenase
chr2_+_234826016 1.22 ENST00000324695.4
ENST00000433712.2
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr5_-_180076613 1.16 ENST00000261937.6
ENST00000393347.3
FLT4
fms-related tyrosine kinase 4
chr16_-_20367584 1.05 ENST00000570689.1
UMOD
uromodulin
chr21_+_38792602 0.98 ENST00000398960.2
ENST00000398956.2
DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr16_+_30662360 0.86 ENST00000542965.2
PRR14
proline rich 14
chrY_+_15016725 0.84 ENST00000336079.3
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
chrX_-_100548045 0.76 ENST00000372907.3
ENST00000372905.2
TAF7L
TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
chr10_+_50817141 0.75 ENST00000339797.1
CHAT
choline O-acetyltransferase
chr2_-_74618964 0.56 ENST00000417090.1
ENST00000409868.1
DCTN1
dynactin 1
chr1_+_174669653 0.44 ENST00000325589.5
RABGAP1L
RAB GTPase activating protein 1-like
chr3_+_8543393 0.33 ENST00000157600.3
ENST00000415597.1
ENST00000535732.1
LMCD1
LIM and cysteine-rich domains 1
chr14_-_106816253 0.31 ENST00000390615.2
IGHV3-33
immunoglobulin heavy variable 3-33

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF232

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 7.5 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
0.7 4.4 GO:0046208 spermine catabolic process(GO:0046208)
0.6 1.9 GO:0006522 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080)
0.6 2.4 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.5 5.4 GO:0035865 cellular response to potassium ion(GO:0035865)
0.5 8.2 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.4 1.3 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.4 5.0 GO:0060312 regulation of blood vessel remodeling(GO:0060312)
0.4 9.9 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.4 9.7 GO:0070233 negative regulation of T cell apoptotic process(GO:0070233)
0.3 1.6 GO:0032661 regulation of interleukin-18 production(GO:0032661)
0.3 4.5 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.2 1.2 GO:0050955 thermoception(GO:0050955)
0.2 1.8 GO:1904469 positive regulation of tumor necrosis factor secretion(GO:1904469)
0.2 1.0 GO:0072233 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.2 3.4 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.1 2.4 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.1 1.6 GO:0070986 left/right axis specification(GO:0070986)
0.1 5.8 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 5.0 GO:0018149 peptide cross-linking(GO:0018149)
0.1 2.6 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.1 6.5 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.0 1.0 GO:0090312 positive regulation of protein deacetylation(GO:0090312)
0.0 2.2 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 5.4 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.0 6.5 GO:0000070 mitotic sister chromatid segregation(GO:0000070)
0.0 19.5 GO:0043687 post-translational protein modification(GO:0043687)
0.0 0.8 GO:0042136 neurotransmitter biosynthetic process(GO:0042136)
0.0 6.3 GO:0010212 response to ionizing radiation(GO:0010212)
0.0 17.2 GO:0016567 protein ubiquitination(GO:0016567)
0.0 0.8 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 2.6 GO:0007565 female pregnancy(GO:0007565)
0.0 1.5 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.3 GO:0070876 SOSS complex(GO:0070876)
1.5 7.5 GO:0010370 perinucleolar chromocenter(GO:0010370)
0.5 4.5 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.3 23.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 2.4 GO:0043194 axon initial segment(GO:0043194)
0.1 9.9 GO:0072686 mitotic spindle(GO:0072686)
0.1 5.0 GO:0001533 cornified envelope(GO:0001533)
0.1 32.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 10.6 GO:0030426 growth cone(GO:0030426)
0.0 9.9 GO:0031012 extracellular matrix(GO:0031012)
0.0 1.9 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 11.7 GO:0016607 nuclear speck(GO:0016607)
0.0 1.8 GO:0035580 specific granule lumen(GO:0035580)
0.0 5.8 GO:0036464 cytoplasmic ribonucleoprotein granule(GO:0036464)
0.0 10.7 GO:0016324 apical plasma membrane(GO:0016324)
0.0 12.0 GO:0005635 nuclear envelope(GO:0005635)
0.0 9.9 GO:0005813 centrosome(GO:0005813)
0.0 1.2 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 5.4 GO:0005743 mitochondrial inner membrane(GO:0005743) organelle inner membrane(GO:0019866)
0.0 1.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.8 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 5.0 GO:0043235 receptor complex(GO:0043235)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.4 GO:0047783 steroid 11-beta-monooxygenase activity(GO:0004507) corticosterone 18-monooxygenase activity(GO:0047783)
1.8 5.4 GO:0015361 low-affinity sodium:dicarboxylate symporter activity(GO:0015361)
1.5 4.4 GO:0052895 norspermine:oxygen oxidoreductase activity(GO:0052894) N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity(GO:0052895)
1.1 4.5 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.6 10.7 GO:0019864 IgG binding(GO:0019864)
0.4 33.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.4 3.5 GO:0034711 inhibin binding(GO:0034711)
0.4 5.0 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.2 6.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 0.8 GO:0004102 choline O-acetyltransferase activity(GO:0004102)
0.2 2.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 1.3 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.1 7.5 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 1.9 GO:0008483 transaminase activity(GO:0008483)
0.1 5.8 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 2.6 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 1.0 GO:0048156 tau protein binding(GO:0048156)
0.0 2.4 GO:0030507 spectrin binding(GO:0030507)
0.0 2.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 17.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 2.4 GO:0035254 glutamate receptor binding(GO:0035254)
0.0 3.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 9.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.8 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 14.9 GO:0001071 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.0 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 33.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 8.2 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 7.5 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 2.4 PID RAS PATHWAY Regulation of Ras family activation
0.0 2.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.3 5.0 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 5.4 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.2 4.4 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 7.5 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 1.3 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.1 2.4 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 2.6 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 2.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.0 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 2.2 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 14.9 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.0 0.8 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle