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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ZNF282
Z-value: 0.77
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Transcription factors associated with ZNF282
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF282 | hg19_v2_chr7_+_148892557_148892580 | 0.50 | 2.6e-15 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF282
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 44.1 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.3 | 27.2 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 6.3 | 25.0 | GO:1902626 | assembly of large subunit precursor of preribosome(GO:1902626) |
| 0.2 | 23.6 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.1 | 20.9 | GO:0007224 | smoothened signaling pathway(GO:0007224) |
| 0.0 | 20.7 | GO:0002283 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 0.2 | 18.4 | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178) |
| 0.5 | 17.8 | GO:0006622 | protein targeting to lysosome(GO:0006622) |
| 1.1 | 17.5 | GO:2000480 | negative regulation of meiotic nuclear division(GO:0045835) negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 5.7 | 17.1 | GO:2000521 | negative regulation of immunological synapse formation(GO:2000521) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 44.1 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 2.3 | 27.2 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.8 | 25.0 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.2 | 20.8 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 1.2 | 17.8 | GO:0044754 | autolysosome(GO:0044754) |
| 0.9 | 17.5 | GO:0031588 | cAMP-dependent protein kinase complex(GO:0005952) nucleotide-activated protein kinase complex(GO:0031588) |
| 0.1 | 17.3 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.3 | 17.1 | GO:0001772 | immunological synapse(GO:0001772) |
| 5.6 | 16.8 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 1.1 | 15.7 | GO:0097227 | sperm annulus(GO:0097227) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 44.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.9 | 27.2 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.6 | 25.9 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 5.0 | 25.0 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.6 | 23.6 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 21.6 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 20.8 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.6 | 18.8 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.2 | 17.8 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.9 | 17.5 | GO:0008603 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) cAMP-dependent protein kinase regulator activity(GO:0008603) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 27.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 25.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 24.1 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.2 | 23.6 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.2 | 17.8 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 17.5 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.3 | 14.3 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.4 | 12.7 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 7.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 5.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 44.1 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.4 | 27.2 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.5 | 17.5 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.5 | 16.6 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.2 | 13.4 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.8 | 13.1 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.3 | 12.7 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.3 | 10.5 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.4 | 10.0 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.5 | 7.9 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |