ISMARA results: ZNF35

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for ZNF35

Z-value: 0.70

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Transcription factors associated with ZNF35

Gene Symbol	Gene ID	Gene Info
ZNF35 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000169981.6	zinc finger protein 35

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ZNF35	hg19_v2_chr3_+_44690211_44690267	0.60	2.5e-22	Click!

Activity profile of ZNF35 motif

Sorted Z-values of ZNF35 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr18_+_74240610 Show fit	19.75	ENST00000578092.1 ENST00000578613.1 ENST00000583578.1	LINC00908 Ensembl NCBI GeneCards UniProt NextProt Show fit	long intergenic non-protein coding RNA 908
chr13_-_41240717 Show fit	5.70	ENST00000379561.5	FOXO1 Ensembl NCBI GeneCards UniProt NextProt Show fit	forkhead box O1
chr1_+_220701456 Show fit	4.40	ENST00000366918.4 ENST00000402574.1	MARK1 Ensembl NCBI GeneCards UniProt NextProt Show fit	MAP/microtubule affinity-regulating kinase 1
chr14_-_31889782 Show fit	4.23	ENST00000543095.2	HEATR5A Ensembl NCBI GeneCards UniProt NextProt Show fit	HEAT repeat containing 5A
chr4_+_88754069 Show fit	4.08	ENST00000395102.4 ENST00000497649.2	MEPE Ensembl NCBI GeneCards UniProt NextProt Show fit	matrix extracellular phosphoglycoprotein
chr12_+_25205446 Show fit	3.58	ENST00000557489.1 ENST00000354454.3 ENST00000536173.1	LRMP Ensembl NCBI GeneCards UniProt NextProt Show fit	lymphoid-restricted membrane protein
chr12_+_25205666 Show fit	3.35	ENST00000547044.1	LRMP Ensembl NCBI GeneCards UniProt NextProt Show fit	lymphoid-restricted membrane protein
chr13_-_36429763 Show fit	3.30	ENST00000379893.1	DCLK1 Ensembl NCBI GeneCards UniProt NextProt Show fit	doublecortin-like kinase 1
chr5_-_39203093 Show fit	3.27	ENST00000515010.1	FYB Ensembl NCBI GeneCards UniProt NextProt Show fit	FYN binding protein
chr10_-_52645379 Show fit	3.09	ENST00000395489.2	A1CF Ensembl NCBI GeneCards UniProt NextProt Show fit	APOBEC1 complementation factor

Showing 1 to 10 of 55 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF35

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.5	GO:0007338	single fertilization(GO:0007338)
0.3	7.1	GO:0030502	negative regulation of bone mineralization(GO:0030502)
1.1	5.7	GO:0035947	regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) response to fluoride(GO:1902617)
0.9	5.6	GO:0016554	cytidine to uridine editing(GO:0016554)
0.0	4.4	GO:0030010	establishment of cell polarity(GO:0030010)
0.1	3.3	GO:0021952	central nervous system projection neuron axonogenesis(GO:0021952)
0.1	2.7	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.1	2.6	GO:0071481	cellular response to X-ray(GO:0071481)
0.2	2.5	GO:0008627	intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.0	2.5	GO:0086010	membrane depolarization during action potential(GO:0086010)

Showing 1 to 10 of 38 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	8.3	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.1	6.9	GO:0035577	azurophil granule membrane(GO:0035577)
1.9	5.6	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.1	4.1	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	3.3	GO:0099572	postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0	3.1	GO:0005811	lipid particle(GO:0005811)
0.4	2.6	GO:0097129	cyclin D2-CDK4 complex(GO:0097129)
0.1	2.5	GO:0033270	voltage-gated sodium channel complex(GO:0001518) paranode region of axon(GO:0033270)
0.1	2.2	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.4	2.0	GO:0060201	clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)

Showing 1 to 10 of 22 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	7.1	GO:1990430	extracellular matrix protein binding(GO:1990430)
0.2	5.7	GO:0001223	transcription coactivator binding(GO:0001223)
0.1	5.6	GO:0003725	double-stranded RNA binding(GO:0003725)
0.2	4.4	GO:0050321	tau-protein kinase activity(GO:0050321) phosphatidic acid binding(GO:0070300)
0.0	3.3	GO:0005057	receptor signaling protein activity(GO:0005057)
0.0	3.1	GO:0008168	methyltransferase activity(GO:0008168)
0.1	2.5	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.1	2.5	GO:0005248	voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0	2.4	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.3	2.2	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)

Showing 1 to 10 of 32 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.1	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	5.7	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	3.3	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	2.6	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	2.2	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	2.2	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.0	2.0	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.0	2.0	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.0	1.7	PID IGF1 PATHWAY	IGF1 pathway
0.0	1.7	PID CDC42 REG PATHWAY	Regulation of CDC42 activity

Showing 1 to 10 of 12 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	5.7	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.1	3.3	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	2.6	REACTOME G1 PHASE	Genes involved in G1 Phase
0.1	2.5	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	2.5	REACTOME REGULATION OF INSULIN SECRETION	Genes involved in Regulation of Insulin Secretion
0.1	2.0	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.1	2.0	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0	1.7	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	1.7	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	1.6	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases

Showing 1 to 10 of 17 entries

Results for ZNF35

Z-value: 0.70

Motif logo

Transcription factors associated with ZNF35

Activity-expression correlation:

Activity profile of ZNF35 motif

Sorted Z-values of ZNF35 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF35

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: