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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for ZNF35

Z-value: 0.70

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Transcription factors associated with ZNF35

Gene Symbol Gene ID Gene Info
ZNF35
ENSG00000169981.6 zinc finger protein 35

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF35hg19_v2_chr3_+_44690211_446902670.602.5e-22Click!

Activity profile of ZNF35 motif

Sorted Z-values of ZNF35 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_+_74240610 19.75 ENST00000578092.1
ENST00000578613.1
ENST00000583578.1
LINC00908
long intergenic non-protein coding RNA 908
chr13_-_41240717 5.70 ENST00000379561.5
FOXO1
forkhead box O1
chr1_+_220701456 4.40 ENST00000366918.4
ENST00000402574.1
MARK1
MAP/microtubule affinity-regulating kinase 1
chr14_-_31889782 4.23 ENST00000543095.2
HEATR5A
HEAT repeat containing 5A
chr4_+_88754069 4.08 ENST00000395102.4
ENST00000497649.2
MEPE
matrix extracellular phosphoglycoprotein
chr12_+_25205446 3.58 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
LRMP
lymphoid-restricted membrane protein
chr12_+_25205666 3.35 ENST00000547044.1
LRMP
lymphoid-restricted membrane protein
chr13_-_36429763 3.30 ENST00000379893.1
DCLK1
doublecortin-like kinase 1
chr5_-_39203093 3.27 ENST00000515010.1
FYB
FYN binding protein
chr10_-_52645379 3.09 ENST00000395489.2
A1CF
APOBEC1 complementation factor
chr12_+_51318513 3.07 ENST00000332160.4
METTL7A
methyltransferase like 7A
chr4_+_88754113 3.02 ENST00000560249.1
ENST00000540395.1
ENST00000511670.1
ENST00000361056.3
MEPE
matrix extracellular phosphoglycoprotein
chr12_+_4382917 2.58 ENST00000261254.3
CCND2
cyclin D2
chr10_-_52645416 2.55 ENST00000374001.2
ENST00000373997.3
ENST00000373995.3
ENST00000282641.2
ENST00000395495.1
ENST00000414883.1
A1CF
APOBEC1 complementation factor
chr19_-_13617247 2.53 ENST00000573710.2
CACNA1A
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
chr2_+_166150541 2.53 ENST00000283256.6
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr3_+_29323043 2.45 ENST00000452462.1
ENST00000456853.1
RBMS3
RNA binding motif, single stranded interacting protein 3
chr1_-_12677714 2.20 ENST00000376223.2
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr21_-_42219065 2.04 ENST00000400454.1
DSCAM
Down syndrome cell adhesion molecule
chr4_+_68424434 2.04 ENST00000265404.2
ENST00000396225.1
STAP1
signal transducing adaptor family member 1
chr6_-_133084580 1.98 ENST00000525270.1
ENST00000530536.1
ENST00000524919.1
VNN2
vanin 2
chr8_+_85095769 1.98 ENST00000518566.1
RALYL
RALY RNA binding protein-like
chr12_+_79258444 1.96 ENST00000261205.4
SYT1
synaptotagmin I
chr12_+_54891495 1.95 ENST00000293373.6
NCKAP1L
NCK-associated protein 1-like
chr7_+_74072288 1.83 ENST00000443166.1
GTF2I
general transcription factor IIi
chr17_-_58042075 1.75 ENST00000305783.8
ENST00000589113.1
ENST00000442346.2
RNFT1
ring finger protein, transmembrane 1
chrX_-_138724677 1.73 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
MCF2
MCF.2 cell line derived transforming sequence
chr12_-_102872317 1.70 ENST00000424202.2
IGF1
insulin-like growth factor 1 (somatomedin C)
chr4_-_89744365 1.64 ENST00000513837.1
ENST00000503556.1
FAM13A
family with sequence similarity 13, member A
chr5_-_58571935 1.62 ENST00000503258.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr7_+_27282319 1.49 ENST00000222761.3
EVX1
even-skipped homeobox 1
chr6_-_135271219 1.43 ENST00000367847.2
ENST00000367845.2
ALDH8A1
aldehyde dehydrogenase 8 family, member A1
chr12_-_22487618 1.39 ENST00000404299.3
ENST00000396037.4
ST8SIA1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr15_+_35270552 1.38 ENST00000391457.2
AC114546.1
HCG37415; PRO1914; Uncharacterized protein
chrM_+_4431 1.32 ENST00000361453.3
MT-ND2
mitochondrially encoded NADH dehydrogenase 2
chr7_+_123488124 1.24 ENST00000476325.1
HYAL4
hyaluronoglucosaminidase 4
chr3_-_148939835 1.16 ENST00000264613.6
CP
ceruloplasmin (ferroxidase)
chr1_+_214161272 1.16 ENST00000498508.2
ENST00000366958.4
PROX1
prospero homeobox 1
chr2_+_177015122 1.15 ENST00000468418.3
HOXD3
homeobox D3
chr1_-_169599353 1.13 ENST00000367793.2
ENST00000367794.2
ENST00000367792.2
ENST00000367791.2
ENST00000367788.2
SELP
selectin P (granule membrane protein 140kDa, antigen CD62)
chr7_-_87342564 1.03 ENST00000265724.3
ENST00000416177.1
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr17_-_42295870 0.98 ENST00000526094.1
ENST00000529383.1
ENST00000530828.1
UBTF
upstream binding transcription factor, RNA polymerase I
chr3_+_69985792 0.77 ENST00000531774.1
MITF
microphthalmia-associated transcription factor
chr12_-_11091862 0.67 ENST00000537503.1
TAS2R14
taste receptor, type 2, member 14
chr13_-_53422640 0.62 ENST00000338862.4
ENST00000377942.3
PCDH8
protocadherin 8
chr14_-_92198403 0.62 ENST00000553329.1
ENST00000256343.3
CATSPERB
catsper channel auxiliary subunit beta
chr7_+_80231466 0.61 ENST00000309881.7
ENST00000534394.1
CD36
CD36 molecule (thrombospondin receptor)
chr13_+_109248500 0.61 ENST00000356711.2
MYO16
myosin XVI
chr18_+_39535152 0.45 ENST00000262039.4
ENST00000398870.3
ENST00000586545.1
PIK3C3
phosphatidylinositol 3-kinase, catalytic subunit type 3
chr20_+_56964169 0.42 ENST00000475243.1
VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr13_-_47471155 0.29 ENST00000543956.1
ENST00000542664.1
HTR2A
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
chrX_+_9431324 0.25 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
TBL1X
transducin (beta)-like 1X-linked
chr17_+_41561317 0.22 ENST00000540306.1
ENST00000262415.3
ENST00000605777.1
DHX8
DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr4_+_70796784 0.16 ENST00000246891.4
ENST00000444405.3
CSN1S1
casein alpha s1
chr3_-_58523010 0.13 ENST00000459701.2
ENST00000302819.5
ACOX2
acyl-CoA oxidase 2, branched chain

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF35

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 5.7 GO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) response to fluoride(GO:1902617)
0.9 5.6 GO:0016554 cytidine to uridine editing(GO:0016554)
0.7 2.0 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760) negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
0.7 2.0 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.5 1.5 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.5 2.0 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376) actin polymerization-dependent cell motility(GO:0070358)
0.4 1.2 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.4 1.8 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.3 1.7 GO:1904073 trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.3 7.1 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.2 1.1 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.2 2.0 GO:0015939 pantothenate metabolic process(GO:0015939)
0.2 2.5 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.2 1.6 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.2 1.0 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.2 2.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 2.0 GO:0048842 positive regulation of axon extension involved in axon guidance(GO:0048842)
0.1 1.4 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1 2.6 GO:0071481 cellular response to X-ray(GO:0071481)
0.1 3.3 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 0.4 GO:0030242 pexophagy(GO:0030242)
0.1 0.6 GO:0072564 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.1 1.1 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.1 1.0 GO:1902659 regulation of glucose mediated signaling pathway(GO:1902659)
0.1 2.7 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.3 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.1 7.5 GO:0007338 single fertilization(GO:0007338)
0.1 1.4 GO:0097503 sialylation(GO:0097503)
0.0 0.4 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0 2.5 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 1.2 GO:0006825 copper ion transport(GO:0006825)
0.0 1.2 GO:0030207 chondroitin sulfate catabolic process(GO:0030207)
0.0 4.4 GO:0030010 establishment of cell polarity(GO:0030010)
0.0 0.7 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 1.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 2.4 GO:0045727 positive regulation of translation(GO:0045727)
0.0 1.7 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 0.6 GO:0001756 somitogenesis(GO:0001756)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.6 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.4 2.6 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.4 2.0 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.2 1.7 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.2 1.1 GO:0031088 platelet dense granule membrane(GO:0031088)
0.1 0.4 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.1 2.5 GO:0033270 voltage-gated sodium channel complex(GO:0001518) paranode region of axon(GO:0033270)
0.1 2.0 GO:0031209 SCAR complex(GO:0031209)
0.1 2.2 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 0.6 GO:0036128 CatSper complex(GO:0036128)
0.1 6.9 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 4.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.3 GO:0070852 cell body fiber(GO:0070852)
0.0 3.1 GO:0005811 lipid particle(GO:0005811)
0.0 0.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 1.3 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 8.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.1 GO:0016235 aggresome(GO:0016235)
0.0 0.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 2.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 3.3 GO:0099572 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 2.0 GO:0030426 growth cone(GO:0030426)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 7.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.4 2.0 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.4 2.0 GO:0030348 syntaxin-3 binding(GO:0030348)
0.4 1.1 GO:0042806 fucose binding(GO:0042806)
0.3 2.0 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.3 2.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 1.0 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.2 4.4 GO:0050321 tau-protein kinase activity(GO:0050321) phosphatidic acid binding(GO:0070300)
0.2 1.4 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.2 5.7 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 1.2 GO:0050692 DBD domain binding(GO:0050692)
0.1 1.0 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.1 0.4 GO:0033149 FFAT motif binding(GO:0033149)
0.1 1.4 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.1 1.2 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 2.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 1.2 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.1 2.5 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 0.6 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 1.6 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.1 0.7 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 5.6 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 1.7 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 1.8 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.1 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.0 1.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 2.4 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.3 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 2.0 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 1.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 3.3 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 3.1 GO:0008168 methyltransferase activity(GO:0008168)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.7 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 2.6 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 2.0 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 1.7 PID IGF1 PATHWAY IGF1 pathway
0.0 3.3 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 1.7 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 7.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.2 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.1 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 2.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.0 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.7 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.7 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 2.0 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.1 2.0 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 3.3 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 1.0 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 2.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.2 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 2.6 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 1.7 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 1.0 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 1.3 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 2.5 REACTOME REGULATION OF INSULIN SECRETION Genes involved in Regulation of Insulin Secretion
0.0 0.3 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 1.6 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+