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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ZNF350
Z-value: 0.77
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Transcription factors associated with ZNF350
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF350 | hg19_v2_chr19_-_52489923_52490113 | 0.42 | 6.9e-11 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF350
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.3 | GO:0070373 | negative regulation of ERK1 and ERK2 cascade(GO:0070373) |
| 0.1 | 12.3 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 1.5 | 10.3 | GO:0046485 | ether lipid metabolic process(GO:0046485) |
| 0.9 | 9.4 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
| 0.1 | 9.4 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
| 0.3 | 8.6 | GO:0032897 | negative regulation of viral transcription(GO:0032897) |
| 1.4 | 8.4 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 1.2 | 7.2 | GO:0060136 | embryonic process involved in female pregnancy(GO:0060136) |
| 0.3 | 7.0 | GO:0010172 | embryonic body morphogenesis(GO:0010172) |
| 1.6 | 6.3 | GO:0042231 | interleukin-13 biosynthetic process(GO:0042231) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.8 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 10.8 | GO:0005770 | late endosome(GO:0005770) |
| 0.1 | 10.3 | GO:0031903 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 2.1 | 8.4 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
| 0.1 | 7.7 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 6.8 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.1 | 6.3 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 5.0 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 4.8 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.1 | 4.5 | GO:1904115 | axon cytoplasm(GO:1904115) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.3 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 2.1 | 10.3 | GO:0052740 | 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740) |
| 0.9 | 9.4 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.6 | 8.4 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.0 | 8.4 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 7.9 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 1.7 | 6.8 | GO:0035473 | lipase binding(GO:0035473) |
| 0.3 | 6.6 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 6.3 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 6.0 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 6.3 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.2 | 6.1 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 5.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 5.0 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.1 | 4.4 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.1 | 3.3 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.1 | 2.8 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 2.7 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 2.3 | PID RAS PATHWAY | Regulation of Ras family activation |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.0 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 12.3 | REACTOME SIGNALING BY SCF KIT | Genes involved in Signaling by SCF-KIT |
| 0.6 | 10.3 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.1 | 6.3 | REACTOME SIGNALING BY ILS | Genes involved in Signaling by Interleukins |
| 0.2 | 5.3 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.2 | 5.1 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.3 | 4.8 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.1 | 4.4 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 4.1 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 3.9 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |