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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for ZNF423

Z-value: 0.62

Motif logo

Transcription factors associated with ZNF423

Gene Symbol Gene ID Gene Info
ENSG00000102935.7 zinc finger protein 423

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF423hg19_v2_chr16_-_49890016_49890046-0.366.3e-08Click!

Activity profile of ZNF423 motif

Sorted Z-values of ZNF423 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_135385202 17.08 ENST00000514554.1
transforming growth factor, beta-induced, 68kDa
chrX_+_49028265 13.75 ENST00000376322.3
ENST00000376327.5
proteolipid protein 2 (colonic epithelium-enriched)
chr10_+_124914285 12.57 ENST00000407911.2
BUB3 mitotic checkpoint protein
chr3_-_195808980 11.41 ENST00000360110.4
transferrin receptor
chr3_-_195808952 11.38 ENST00000540528.1
ENST00000392396.3
ENST00000535031.1
ENST00000420415.1
transferrin receptor
chr3_-_69129501 11.34 ENST00000540295.1
ENST00000415609.2
ENST00000361055.4
ENST00000349511.4
ubiquitin-like modifier activating enzyme 3
chr10_-_121296045 10.88 ENST00000392865.1
regulator of G-protein signaling 10
chr11_-_64013663 10.15 ENST00000392210.2
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr9_+_112542591 9.21 ENST00000483909.1
ENST00000314527.4
ENST00000413420.1
ENST00000302798.7
ENST00000555236.1
ENST00000510514.5
paralemmin 2
PALM2-AKAP2 readthrough
A kinase (PRKA) anchor protein 2
chr1_+_10459111 9.00 ENST00000541529.1
ENST00000270776.8
ENST00000483936.1
ENST00000538557.1
phosphogluconate dehydrogenase
chr10_+_124913930 8.71 ENST00000368858.5
BUB3 mitotic checkpoint protein
chr9_+_112542572 8.44 ENST00000374530.3
PALM2-AKAP2 readthrough
chr16_-_11681316 8.40 ENST00000571688.1
lipopolysaccharide-induced TNF factor
chr15_-_59225758 8.21 ENST00000558486.1
ENST00000560682.1
ENST00000249736.7
ENST00000559880.1
ENST00000536328.1
SAFB-like, transcription modulator
chr16_-_11681023 8.16 ENST00000570904.1
ENST00000574701.1
lipopolysaccharide-induced TNF factor
chr17_-_73178599 7.11 ENST00000578238.1
small ubiquitin-like modifier 2
chr3_+_180630444 6.95 ENST00000491062.1
ENST00000468861.1
ENST00000445140.2
ENST00000484958.1
fragile X mental retardation, autosomal homolog 1
chr2_+_171785012 6.85 ENST00000234160.4
golgi reassembly stacking protein 2, 55kDa
chr2_+_46769798 6.62 ENST00000238738.4
ras homolog family member Q
chr10_+_17271266 6.58 ENST00000224237.5
vimentin
chr3_+_180630090 5.84 ENST00000357559.4
ENST00000305586.7
fragile X mental retardation, autosomal homolog 1
chr10_+_124913793 5.77 ENST00000368865.4
ENST00000538238.1
ENST00000368859.2
BUB3 mitotic checkpoint protein
chr19_+_14544099 5.67 ENST00000242783.6
ENST00000586557.1
ENST00000590097.1
protein kinase N1
chr5_-_172756506 5.56 ENST00000265087.4
stanniocalcin 2
chr21_-_18985230 5.15 ENST00000457956.1
ENST00000348354.6
BTG family, member 3
chr17_-_73179046 4.99 ENST00000314523.7
ENST00000420826.2
small ubiquitin-like modifier 2
chr8_-_103668114 4.81 ENST00000285407.6
Kruppel-like factor 10
chr19_-_10450328 4.67 ENST00000160262.5
intercellular adhesion molecule 3
chr17_+_6347729 4.67 ENST00000572447.1
family with sequence similarity 64, member A
chr21_-_18985158 4.55 ENST00000339775.6
BTG family, member 3
chr11_-_61658853 4.54 ENST00000525588.1
ENST00000540820.1
fatty acid desaturase 3
chr17_+_6347761 4.51 ENST00000250056.8
ENST00000571373.1
ENST00000570337.2
ENST00000572595.2
ENST00000576056.1
family with sequence similarity 64, member A
chr2_+_171785824 4.36 ENST00000452526.2
golgi reassembly stacking protein 2, 55kDa
chr19_+_41770236 4.11 ENST00000392006.3
heterogeneous nuclear ribonucleoprotein U-like 1
chr15_-_59225844 4.05 ENST00000380516.2
SAFB-like, transcription modulator
chr19_+_41770349 3.74 ENST00000602130.1
heterogeneous nuclear ribonucleoprotein U-like 1
chr22_+_35653445 3.65 ENST00000420166.1
ENST00000444518.2
ENST00000455359.1
ENST00000216106.5
HMG box domain containing 4
chr1_+_155278625 3.63 ENST00000368356.4
ENST00000356657.6
farnesyl diphosphate synthase
chr19_-_10450287 3.61 ENST00000589261.1
ENST00000590569.1
ENST00000589580.1
ENST00000589249.1
intercellular adhesion molecule 3
chr11_-_67120974 3.59 ENST00000539074.1
ENST00000312419.3
polymerase (DNA-directed), delta 4, accessory subunit
chr20_+_43514320 3.43 ENST00000372839.3
ENST00000428262.1
ENST00000445830.1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
chr4_+_74735102 3.42 ENST00000395761.3
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr1_-_35658736 3.32 ENST00000357214.5
splicing factor proline/glutamine-rich
chr19_-_11689752 3.24 ENST00000592659.1
ENST00000592828.1
ENST00000218758.5
ENST00000412435.2
acid phosphatase 5, tartrate resistant
chr8_+_30241934 3.09 ENST00000538486.1
RNA binding protein with multiple splicing
chr11_-_61659006 3.04 ENST00000278829.2
fatty acid desaturase 3
chr20_+_43514315 2.97 ENST00000353703.4
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
chr7_-_5570229 2.63 ENST00000331789.5
actin, beta
chr12_-_57522813 2.61 ENST00000556155.1
signal transducer and activator of transcription 6, interleukin-4 induced
chr15_+_41523335 2.48 ENST00000334660.5
calcineurin-like EF-hand protein 1
chr8_+_22022800 2.34 ENST00000397814.3
bone morphogenetic protein 1
chr12_-_125348329 2.26 ENST00000546215.1
ENST00000415380.2
ENST00000261693.6
ENST00000376788.1
ENST00000545493.1
scavenger receptor class B, member 1
chr15_-_66649010 2.22 ENST00000367709.4
ENST00000261881.4
TIMELESS interacting protein
chr10_-_75255668 1.98 ENST00000545874.1
protein phosphatase 3, catalytic subunit, beta isozyme
chr19_+_41770269 1.91 ENST00000378215.4
heterogeneous nuclear ribonucleoprotein U-like 1
chr12_-_125348448 1.91 ENST00000339570.5
scavenger receptor class B, member 1
chr11_-_44972418 1.88 ENST00000525680.1
ENST00000528290.1
ENST00000530035.1
tumor protein p53 inducible protein 11
chrX_-_48827976 1.85 ENST00000218176.3
potassium voltage-gated channel, Shal-related subfamily, member 1
chr1_+_26644441 1.64 ENST00000374213.2
CD52 molecule
chr6_+_33589161 1.63 ENST00000605930.1
inositol 1,4,5-trisphosphate receptor, type 3
chr7_+_101460882 1.60 ENST00000292535.7
ENST00000549414.2
ENST00000550008.2
ENST00000546411.2
ENST00000556210.1
cut-like homeobox 1
chr7_-_30029367 1.51 ENST00000242059.5
secernin 1
chr12_-_118810688 1.44 ENST00000542532.1
ENST00000392533.3
TAO kinase 3
chr17_+_28705921 1.37 ENST00000225719.4
carboxypeptidase D
chr16_+_27325202 1.36 ENST00000395762.2
ENST00000562142.1
ENST00000561742.1
ENST00000543915.2
ENST00000449195.1
ENST00000380922.3
ENST00000563002.1
interleukin 4 receptor
chr7_-_150754935 1.34 ENST00000297518.4
cyclin-dependent kinase 5
chr15_+_100106244 1.34 ENST00000557942.1
myocyte enhancer factor 2A
chr8_+_22022653 1.33 ENST00000354870.5
ENST00000397816.3
ENST00000306349.8
bone morphogenetic protein 1
chr9_-_35619539 1.24 ENST00000396757.1
CD72 molecule
chr6_-_32160622 1.12 ENST00000487761.1
ENST00000375040.3
G-protein signaling modulator 3
chr1_-_165414414 1.11 ENST00000359842.5
retinoid X receptor, gamma
chr8_+_30241995 1.06 ENST00000397323.4
ENST00000339877.4
ENST00000320203.4
ENST00000287771.5
RNA binding protein with multiple splicing
chr12_+_52643077 1.04 ENST00000553310.2
ENST00000544024.1
keratin 86
chr10_-_118032979 1.03 ENST00000355422.6
GDNF family receptor alpha 1
chr8_+_22022223 0.98 ENST00000306385.5
bone morphogenetic protein 1
chr19_-_23941639 0.96 ENST00000395385.3
ENST00000531570.1
ENST00000528059.1
zinc finger protein 681
chr22_-_43045574 0.95 ENST00000352397.5
cytochrome b5 reductase 3
chr6_+_30131318 0.89 ENST00000376688.1
tripartite motif containing 15
chrX_+_152760397 0.88 ENST00000331595.4
ENST00000431891.1
biglycan
chr19_-_23941680 0.80 ENST00000402377.3
zinc finger protein 681
chr8_-_42234745 0.74 ENST00000220812.2
dickkopf WNT signaling pathway inhibitor 4
chr3_+_9958758 0.74 ENST00000383812.4
ENST00000438091.1
ENST00000295981.3
ENST00000436503.1
ENST00000403601.3
ENST00000416074.2
ENST00000455057.1
interleukin 17 receptor C
chr2_-_120980939 0.74 ENST00000426077.2
transmembrane protein 185B
chr7_-_27219849 0.73 ENST00000396344.4
homeobox A10
chr8_+_22422749 0.70 ENST00000523900.1
sorbin and SH3 domain containing 3
chr9_-_16870704 0.68 ENST00000380672.4
ENST00000380667.2
ENST00000380666.2
ENST00000486514.1
basonuclin 2
chr6_-_35480705 0.65 ENST00000229771.6
tubby like protein 1
chr1_-_155177677 0.62 ENST00000368378.3
ENST00000541990.1
ENST00000457183.2
thrombospondin 3
chr6_+_30130969 0.55 ENST00000376694.4
tripartite motif containing 15
chr3_+_9958870 0.54 ENST00000413608.1
interleukin 17 receptor C
chr12_+_7037461 0.49 ENST00000396684.2
atrophin 1
chr6_-_35480640 0.48 ENST00000428978.1
ENST00000322263.4
tubby like protein 1
chr11_+_60691924 0.46 ENST00000544065.1
ENST00000453848.2
ENST00000005286.4
transmembrane protein 132A
chr15_+_100106155 0.45 ENST00000557785.1
ENST00000558049.1
ENST00000449277.2
myocyte enhancer factor 2A
chr10_+_135340859 0.37 ENST00000252945.3
ENST00000421586.1
ENST00000418356.1
cytochrome P450, family 2, subfamily E, polypeptide 1
chr8_+_22423219 0.37 ENST00000523965.1
ENST00000521554.1
sorbin and SH3 domain containing 3
chr11_-_44972390 0.36 ENST00000395648.3
ENST00000531928.2
tumor protein p53 inducible protein 11
chr11_-_47207950 0.34 ENST00000298838.6
ENST00000531226.1
ENST00000524509.1
ENST00000528201.1
ENST00000530513.1
protein kinase C and casein kinase substrate in neurons 3
chr20_+_43029911 0.33 ENST00000443598.2
ENST00000316099.4
ENST00000415691.2
hepatocyte nuclear factor 4, alpha
chr6_+_42896865 0.33 ENST00000372836.4
ENST00000394142.3
canopy FGF signaling regulator 3
chr11_-_44972476 0.22 ENST00000527685.1
ENST00000308212.5
tumor protein p53 inducible protein 11
chr7_+_20370300 0.18 ENST00000537992.1
integrin, beta 8
chrX_-_1572629 0.13 ENST00000534940.1
acetylserotonin O-methyltransferase-like
chr16_+_3014269 0.08 ENST00000575885.1
ENST00000571007.1
ENST00000319500.6
kringle containing transmembrane protein 2
chr2_+_62932779 0.08 ENST00000427809.1
ENST00000405482.1
ENST00000431489.1
EH domain binding protein 1
chrX_-_107019181 0.03 ENST00000315660.4
ENST00000372384.2
ENST00000502650.1
ENST00000506724.1
TSC22 domain family, member 3

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF423

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 11.3 GO:0007113 endomitotic cell cycle(GO:0007113)
3.0 9.0 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
1.4 4.2 GO:0015920 lipopolysaccharide transport(GO:0015920)
1.2 22.8 GO:0046852 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.9 5.7 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.7 3.6 GO:0033384 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
0.7 5.6 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.7 27.1 GO:0007094 mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)
0.7 2.6 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.6 3.2 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.6 10.9 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.6 6.6 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.6 12.8 GO:0060148 positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637)
0.6 3.3 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.5 1.6 GO:0050917 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.5 1.4 GO:0007500 mesodermal cell fate determination(GO:0007500) regulation of intracellular transport of viral material(GO:1901252) negative regulation of intracellular transport of viral material(GO:1901253)
0.4 16.6 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.4 2.2 GO:0048478 replication fork protection(GO:0048478)
0.3 6.6 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.3 1.8 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.3 1.4 GO:0045626 negative regulation of T-helper 1 cell differentiation(GO:0045626) response to odorant(GO:1990834)
0.3 2.1 GO:0070885 positive regulation of sodium:proton antiporter activity(GO:0032417) negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.3 4.1 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.2 12.1 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.2 1.3 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.2 4.7 GO:0034380 high-density lipoprotein particle assembly(GO:0034380)
0.2 3.6 GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.2 1.3 GO:0097396 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.1 4.8 GO:0045672 positive regulation of osteoclast differentiation(GO:0045672)
0.1 6.4 GO:0035329 hippo signaling(GO:0035329)
0.1 3.4 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.1 0.7 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.1 16.8 GO:0002062 chondrocyte differentiation(GO:0002062)
0.1 1.0 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.1 1.1 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500) protein localization to photoreceptor outer segment(GO:1903546)
0.1 1.3 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.1 7.6 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636)
0.1 1.1 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.1 11.2 GO:0007030 Golgi organization(GO:0007030)
0.1 1.4 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 0.4 GO:0010193 response to ozone(GO:0010193)
0.1 17.7 GO:0008360 regulation of cell shape(GO:0008360)
0.1 1.3 GO:0003416 endochondral bone growth(GO:0003416)
0.1 12.3 GO:0050684 regulation of mRNA processing(GO:0050684)
0.1 3.6 GO:0008333 endosome to lysosome transport(GO:0008333)
0.1 0.9 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.1 1.6 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.1 1.6 GO:0045730 respiratory burst(GO:0045730)
0.0 0.3 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 2.6 GO:0001895 retina homeostasis(GO:0001895)
0.0 0.9 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.3 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 6.0 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.0 1.1 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.7 GO:0060065 uterus development(GO:0060065)
0.0 8.2 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 13.7 GO:0042330 chemotaxis(GO:0006935) taxis(GO:0042330)
0.0 2.3 GO:0045930 negative regulation of mitotic cell cycle(GO:0045930)
0.0 1.9 GO:0061337 cardiac conduction(GO:0061337)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
9.0 27.1 GO:1990298 mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298)
2.8 16.6 GO:0098560 cytoplasmic side of late endosome membrane(GO:0098560)
1.8 22.8 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.9 3.6 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.5 3.6 GO:0016589 NURF complex(GO:0016589)
0.4 3.3 GO:0042382 paraspeckles(GO:0042382)
0.3 1.3 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.3 12.8 GO:0043034 costamere(GO:0043034)
0.2 2.2 GO:0031298 replication fork protection complex(GO:0031298)
0.2 2.6 GO:0097433 dense body(GO:0097433)
0.1 4.2 GO:0031528 microvillus membrane(GO:0031528)
0.1 1.3 GO:0005955 calcineurin complex(GO:0005955)
0.1 16.8 GO:0005604 basement membrane(GO:0005604)
0.1 6.6 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.1 4.1 GO:0005685 U1 snRNP(GO:0005685)
0.1 1.6 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 12.1 GO:0016605 PML body(GO:0016605)
0.1 5.7 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 0.9 GO:0005833 hemoglobin complex(GO:0005833)
0.1 7.6 GO:0005882 intermediate filament(GO:0005882)
0.1 6.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 10.9 GO:0043197 dendritic spine(GO:0043197)
0.0 3.4 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 1.1 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 4.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 5.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 2.1 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 2.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 4.4 GO:0000790 nuclear chromatin(GO:0000790)
0.0 8.9 GO:0016604 nuclear body(GO:0016604)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
7.6 22.8 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
3.0 9.0 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
2.2 6.6 GO:0032427 GBD domain binding(GO:0032427)
1.4 11.3 GO:0019788 NEDD8 transferase activity(GO:0019788)
1.2 12.8 GO:0002151 G-quadruplex RNA binding(GO:0002151) RNA strand annealing activity(GO:0033592)
1.1 6.6 GO:1990254 keratin filament binding(GO:1990254)
1.0 4.2 GO:0034186 apolipoprotein A-I binding(GO:0034186)
1.0 12.1 GO:0031386 protein tag(GO:0031386)
0.9 5.7 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.9 6.4 GO:0050815 phosphoserine binding(GO:0050815)
0.7 3.6 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.6 4.1 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.5 1.4 GO:0004913 interleukin-4 receptor activity(GO:0004913)
0.4 1.6 GO:0000822 inositol hexakisphosphate binding(GO:0000822) inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.4 13.7 GO:0019956 chemokine binding(GO:0019956)
0.4 16.6 GO:0050699 WW domain binding(GO:0050699)
0.4 10.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 1.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.3 3.2 GO:0008199 ferric iron binding(GO:0008199)
0.2 17.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 1.9 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.2 1.3 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.2 10.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.2 3.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.2 2.6 GO:0030957 Tat protein binding(GO:0030957)
0.2 25.5 GO:0043130 ubiquitin binding(GO:0043130)
0.2 1.3 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 1.0 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.1 1.3 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 3.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 1.4 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 0.9 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 1.5 GO:0016805 dipeptidase activity(GO:0016805)
0.0 8.3 GO:0005178 integrin binding(GO:0005178)
0.0 1.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 4.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 5.8 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 7.7 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 5.6 GO:0005179 hormone activity(GO:0005179)
0.0 2.1 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.3 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.4 GO:0017166 vinculin binding(GO:0017166)
0.0 0.4 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.1 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 25.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.5 11.3 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.3 13.0 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.3 23.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.3 5.7 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 28.4 PID P73PATHWAY p73 transcription factor network
0.1 10.2 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 13.4 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 6.6 PID AURORA B PATHWAY Aurora B signaling
0.1 2.6 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.1 3.4 PID IL23 PATHWAY IL23-mediated signaling events
0.1 2.2 PID ATR PATHWAY ATR signaling pathway
0.0 1.3 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 1.6 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.7 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 1.1 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.7 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 1.8 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.9 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.0 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 2.6 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 4.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 27.1 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.7 22.8 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.5 6.4 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.4 8.8 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.3 3.6 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.2 17.1 REACTOME AMYLOIDS Genes involved in Amyloids
0.2 6.6 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 1.6 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 3.6 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 8.3 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 2.6 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.1 9.8 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 4.2 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 3.4 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.7 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 1.8 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 11.3 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.6 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.9 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 2.6 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 7.6 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.0 1.0 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.2 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.3 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 3.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.4 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.6 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.0 0.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.4 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.1 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway