ISMARA results: ZNF524

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for ZNF524

Z-value: 0.37

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Transcription factors associated with ZNF524

Gene Symbol	Gene ID	Gene Info
ZNF524 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000171443.6	zinc finger protein 524

Activity profile of ZNF524 motif

Sorted Z-values of ZNF524 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_+_222846 Show fit	16.23	ENST00000251595.6 ENST00000397806.1	HBA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	hemoglobin, alpha 2
chr3_+_10206545 Show fit	13.01	ENST00000256458.4	IRAK2 Ensembl NCBI GeneCards UniProt NextProt Show fit	interleukin-1 receptor-associated kinase 2
chr11_-_66725837 Show fit	12.02	ENST00000393958.2 ENST00000393960.1 ENST00000524491.1 ENST00000355677.3	PC Ensembl NCBI GeneCards UniProt NextProt Show fit	pyruvate carboxylase
chr19_-_17185848 Show fit	11.53	ENST00000593360.1	HAUS8 Ensembl NCBI GeneCards UniProt NextProt Show fit	HAUS augmin-like complex, subunit 8
chr17_-_41466555 Show fit	10.08	ENST00000586231.1	LINC00910 Ensembl NCBI GeneCards UniProt NextProt Show fit	long intergenic non-protein coding RNA 910
chr7_+_44143925 Show fit	9.93	ENST00000223357.3	AEBP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	AE binding protein 1
chrX_+_56259316 Show fit	9.78	ENST00000468660.1	KLF8 Ensembl NCBI GeneCards UniProt NextProt Show fit	Kruppel-like factor 8
chr11_-_66336060 Show fit	9.49	ENST00000310325.5	CTSF Ensembl NCBI GeneCards UniProt NextProt Show fit	cathepsin F
chr12_+_57914742 Show fit	9.14	ENST00000551351.1	MBD6 Ensembl NCBI GeneCards UniProt NextProt Show fit	methyl-CpG binding domain protein 6
chr16_+_55542910 Show fit	9.05	ENST00000262134.5	LPCAT2 Ensembl NCBI GeneCards UniProt NextProt Show fit	lysophosphatidylcholine acyltransferase 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF524

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.2	15.5	GO:0019072	viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.8	14.4	GO:0034162	toll-like receptor 9 signaling pathway(GO:0034162)
3.5	14.1	GO:0006542	glutamine biosynthetic process(GO:0006542)
1.5	12.1	GO:0034587	piRNA metabolic process(GO:0034587)
0.2	11.6	GO:0006910	phagocytosis, recognition(GO:0006910)
1.5	10.6	GO:0002414	immunoglobulin transcytosis in epithelial cells(GO:0002414)
1.0	10.6	GO:0002775	antimicrobial peptide production(GO:0002775) antibacterial peptide production(GO:0002778)
2.4	9.6	GO:0019470	4-hydroxyproline catabolic process(GO:0019470)
0.2	9.6	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
3.1	9.2	GO:0007439	ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)

Showing 1 to 10 of 466 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	60.5	GO:0005615	extracellular space(GO:0005615)
0.1	36.8	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.2	20.9	GO:0008076	voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1	18.3	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
2.2	17.7	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.2	17.6	GO:0005930	axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.1	14.4	GO:0031901	early endosome membrane(GO:0031901)
0.1	12.7	GO:0008021	synaptic vesicle(GO:0008021)
0.4	11.9	GO:0000795	synaptonemal complex(GO:0000795)
0.0	9.7	GO:0043235	receptor complex(GO:0043235)

Showing 1 to 10 of 173 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	28.2	GO:0004252	serine-type endopeptidase activity(GO:0004252)
1.5	23.6	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	20.2	GO:0001071	nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.1	18.4	GO:0017137	Rab GTPase binding(GO:0017137)
0.2	17.0	GO:0030971	receptor tyrosine kinase binding(GO:0030971)
4.0	15.9	GO:0097001	ceramide binding(GO:0097001)
1.8	14.3	GO:0004565	beta-galactosidase activity(GO:0004565)
3.5	14.1	GO:0004356	glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.1	12.7	GO:0008083	growth factor activity(GO:0008083)
0.3	12.2	GO:0001103	RNA polymerase II repressing transcription factor binding(GO:0001103)

Showing 1 to 10 of 327 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	35.1	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	27.3	NABA MATRISOME ASSOCIATED	Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.1	25.0	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	21.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3	13.1	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.4	12.1	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.2	10.7	ST GAQ PATHWAY	G alpha q Pathway
0.2	10.0	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.2	8.8	PID S1P S1P3 PATHWAY	S1P3 pathway
0.2	8.4	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway

Showing 1 to 10 of 73 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	26.1	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.4	18.0	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.2	13.9	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.5	13.5	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
1.3	13.0	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.5	12.2	REACTOME ACYL CHAIN REMODELLING OF PC	Genes involved in Acyl chain remodelling of PC
0.8	11.8	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.1	10.6	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.5	10.0	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.2	9.5	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling

Showing 1 to 10 of 117 entries

Results for ZNF524

Z-value: 0.37

Motif logo

Transcription factors associated with ZNF524

Activity profile of ZNF524 motif

Sorted Z-values of ZNF524 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF524

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: