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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for ZNF691

Z-value: 0.80

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Transcription factors associated with ZNF691

Gene Symbol Gene ID Gene Info
ZNF691
ENSG00000164011.13 zinc finger protein 691

Activity profile of ZNF691 motif

Sorted Z-values of ZNF691 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_26644441 18.44 ENST00000374213.2
CD52
CD52 molecule
chr12_-_51717875 13.93 ENST00000604560.1
BIN2
bridging integrator 2
chr22_+_23264766 13.46 ENST00000390331.2
IGLC7
immunoglobulin lambda constant 7
chr12_-_51717948 12.90 ENST00000267012.4
BIN2
bridging integrator 2
chr12_-_51717922 12.35 ENST00000452142.2
BIN2
bridging integrator 2
chr12_-_51718436 11.62 ENST00000544402.1
BIN2
bridging integrator 2
chr1_+_28199047 11.45 ENST00000373925.1
ENST00000328928.7
ENST00000373927.3
ENST00000427466.1
ENST00000442118.1
ENST00000373921.3
THEMIS2
thymocyte selection associated family member 2
chr8_+_27168988 10.99 ENST00000397501.1
ENST00000338238.4
ENST00000544172.1
PTK2B
protein tyrosine kinase 2 beta
chr18_+_74240610 10.43 ENST00000578092.1
ENST00000578613.1
ENST00000583578.1
LINC00908
long intergenic non-protein coding RNA 908
chr3_+_46412345 9.32 ENST00000292303.4
CCR5
chemokine (C-C motif) receptor 5 (gene/pseudogene)
chr2_+_68961934 8.83 ENST00000409202.3
ARHGAP25
Rho GTPase activating protein 25
chr2_+_68961905 8.59 ENST00000295381.3
ARHGAP25
Rho GTPase activating protein 25
chr17_-_61777459 8.17 ENST00000578993.1
ENST00000583211.1
ENST00000259006.3
LIMD2
LIM domain containing 2
chr5_-_131892501 7.90 ENST00000450655.1
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr2_+_68962014 7.80 ENST00000467265.1
ARHGAP25
Rho GTPase activating protein 25
chr6_+_31553978 7.13 ENST00000376096.1
ENST00000376099.1
ENST00000376110.3
LST1
leukocyte specific transcript 1
chr6_+_31553901 7.06 ENST00000418507.2
ENST00000438075.2
ENST00000376100.3
ENST00000376111.4
LST1
leukocyte specific transcript 1
chr11_+_121461097 7.01 ENST00000527934.1
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr8_-_145159083 6.51 ENST00000398712.2
SHARPIN
SHANK-associated RH domain interactor
chr19_-_5903714 5.95 ENST00000586349.1
ENST00000585661.1
ENST00000308961.4
ENST00000592634.1
ENST00000418389.2
ENST00000252675.5
AC024592.12
NDUFA11
FUT5
Uncharacterized protein
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa
fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
chr17_+_80416482 5.89 ENST00000309794.11
ENST00000345415.7
ENST00000457415.3
ENST00000584411.1
ENST00000412079.2
ENST00000577432.1
NARF
nuclear prelamin A recognition factor
chr15_-_86338100 5.39 ENST00000536947.1
KLHL25
kelch-like family member 25
chr3_+_44596679 5.22 ENST00000426540.1
ENST00000431636.1
ENST00000341840.3
ENST00000273320.3
ZKSCAN7
zinc finger with KRAB and SCAN domains 7
chr1_+_26856236 5.16 ENST00000374168.2
ENST00000374166.4
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr12_-_12491608 4.80 ENST00000545735.1
MANSC1
MANSC domain containing 1
chr14_+_103388976 4.69 ENST00000299155.5
AMN
amnion associated transmembrane protein
chr2_+_202098166 4.52 ENST00000392263.2
ENST00000264274.9
ENST00000392259.2
ENST00000392266.3
ENST00000432109.2
ENST00000264275.5
CASP8
caspase 8, apoptosis-related cysteine peptidase
chr10_+_104678102 4.50 ENST00000433628.2
CNNM2
cyclin M2
chr4_-_120243545 4.42 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr13_-_52703187 4.40 ENST00000355568.4
NEK5
NIMA-related kinase 5
chr1_-_33647267 4.35 ENST00000291416.5
TRIM62
tripartite motif containing 62
chr3_-_49907323 4.21 ENST00000296471.7
ENST00000488336.1
ENST00000467248.1
ENST00000466940.1
ENST00000463537.1
ENST00000480398.2
CAMKV
CaM kinase-like vesicle-associated
chr11_-_133826852 4.16 ENST00000533871.2
ENST00000321016.8
IGSF9B
immunoglobulin superfamily, member 9B
chr1_-_203055129 4.07 ENST00000241651.4
MYOG
myogenin (myogenic factor 4)
chr15_-_58571445 3.98 ENST00000558231.1
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr17_+_80416050 3.97 ENST00000579198.1
ENST00000390006.4
ENST00000580296.1
NARF
nuclear prelamin A recognition factor
chr5_-_131347501 3.95 ENST00000543479.1
ACSL6
acyl-CoA synthetase long-chain family member 6
chr10_+_104678032 3.94 ENST00000369878.4
ENST00000369875.3
CNNM2
cyclin M2
chr5_-_35230434 3.67 ENST00000504500.1
PRLR
prolactin receptor
chr19_+_50380917 3.33 ENST00000535102.2
TBC1D17
TBC1 domain family, member 17
chr2_+_202125219 3.29 ENST00000323492.7
CASP8
caspase 8, apoptosis-related cysteine peptidase
chr4_-_7105056 3.27 ENST00000504402.1
ENST00000499242.2
ENST00000501888.2
RP11-367J11.3
RP11-367J11.3
chrX_+_102469997 3.24 ENST00000372695.5
ENST00000372691.3
BEX4
brain expressed, X-linked 4
chrX_+_153775821 3.18 ENST00000263518.6
ENST00000470142.1
ENST00000393549.2
ENST00000455588.2
ENST00000369602.3
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr7_-_143059780 3.08 ENST00000409578.1
ENST00000409346.1
FAM131B
family with sequence similarity 131, member B
chr19_+_50084561 3.08 ENST00000246794.5
PRRG2
proline rich Gla (G-carboxyglutamic acid) 2
chr18_+_74240756 3.01 ENST00000584910.1
ENST00000582452.1
LINC00908
long intergenic non-protein coding RNA 908
chr19_-_50311896 3.00 ENST00000529634.2
FUZ
fuzzy planar cell polarity protein
chr13_-_52027134 2.95 ENST00000311234.4
ENST00000425000.1
ENST00000463928.1
ENST00000442263.3
ENST00000398119.2
INTS6
integrator complex subunit 6
chr14_-_106725723 2.93 ENST00000390609.2
IGHV3-23
immunoglobulin heavy variable 3-23
chr15_-_26108355 2.93 ENST00000356865.6
ATP10A
ATPase, class V, type 10A
chr16_+_84328252 2.88 ENST00000219454.5
WFDC1
WAP four-disulfide core domain 1
chr11_+_60223312 2.83 ENST00000532491.1
ENST00000532073.1
ENST00000534668.1
ENST00000528313.1
ENST00000533306.1
MS4A1
membrane-spanning 4-domains, subfamily A, member 1
chr9_+_135754263 2.81 ENST00000356311.5
ENST00000350499.6
C9orf9
chromosome 9 open reading frame 9
chr6_-_90529418 2.78 ENST00000439638.1
ENST00000369393.3
ENST00000428876.1
MDN1
MDN1, midasin homolog (yeast)
chr11_+_60223225 2.71 ENST00000524807.1
ENST00000345732.4
MS4A1
membrane-spanning 4-domains, subfamily A, member 1
chr20_-_1317555 2.62 ENST00000537552.1
AL136531.1
HCG2043693; Uncharacterized protein
chr12_-_10605929 2.62 ENST00000347831.5
ENST00000359151.3
KLRC1
killer cell lectin-like receptor subfamily C, member 1
chr1_+_203734296 2.60 ENST00000442561.2
ENST00000367217.5
LAX1
lymphocyte transmembrane adaptor 1
chr5_-_131347583 2.54 ENST00000379255.1
ENST00000430403.1
ENST00000544770.1
ENST00000379246.1
ENST00000414078.1
ENST00000441995.1
ACSL6
acyl-CoA synthetase long-chain family member 6
chr16_+_84328429 2.50 ENST00000568638.1
WFDC1
WAP four-disulfide core domain 1
chr19_-_17932314 2.41 ENST00000598577.1
ENST00000317306.7
ENST00000379695.5
INSL3
insulin-like 3 (Leydig cell)
chr3_-_46037299 2.40 ENST00000296137.2
FYCO1
FYVE and coiled-coil domain containing 1
chr4_+_96761238 2.30 ENST00000295266.4
PDHA2
pyruvate dehydrogenase (lipoamide) alpha 2
chr15_-_74726283 2.22 ENST00000543145.2
SEMA7A
semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
chr12_-_23737534 2.15 ENST00000396007.2
SOX5
SRY (sex determining region Y)-box 5
chr4_+_657485 2.13 ENST00000471824.2
PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr6_-_27279949 1.96 ENST00000444565.1
ENST00000377451.2
POM121L2
POM121 transmembrane nucleoporin-like 2
chr3_+_129693523 1.94 ENST00000507066.1
TRH
thyrotropin-releasing hormone
chr16_-_53737795 1.94 ENST00000262135.4
ENST00000564374.1
ENST00000566096.1
RPGRIP1L
RPGRIP1-like
chr1_-_16763911 1.88 ENST00000375577.1
ENST00000335496.1
SPATA21
spermatogenesis associated 21
chr16_+_78133293 1.82 ENST00000566780.1
WWOX
WW domain containing oxidoreductase
chr11_+_33902189 1.81 ENST00000330381.2
AC132216.1
HCG1785179; PRO1787; Uncharacterized protein
chr3_+_37493610 1.79 ENST00000264741.5
ITGA9
integrin, alpha 9
chr19_-_893200 1.71 ENST00000269814.4
ENST00000395808.3
ENST00000312090.6
ENST00000325464.1
MED16
mediator complex subunit 16
chr1_-_205180664 1.69 ENST00000367161.3
ENST00000367162.3
ENST00000367160.4
DSTYK
dual serine/threonine and tyrosine protein kinase
chr11_-_57148619 1.69 ENST00000287143.2
PRG3
proteoglycan 3
chr20_-_2489542 1.64 ENST00000421216.1
ENST00000381253.1
ZNF343
zinc finger protein 343
chr21_-_37852359 1.56 ENST00000399137.1
ENST00000399135.1
CLDN14
claudin 14
chr17_-_41738931 1.47 ENST00000329168.3
ENST00000549132.1
MEOX1
mesenchyme homeobox 1
chr2_+_238475217 1.46 ENST00000165524.1
PRLH
prolactin releasing hormone
chr4_-_16077741 1.44 ENST00000447510.2
ENST00000540805.1
ENST00000539194.1
PROM1
prominin 1
chr16_-_53737722 1.44 ENST00000569716.1
ENST00000562588.1
ENST00000562230.1
ENST00000379925.3
ENST00000563746.1
ENST00000568653.3
RPGRIP1L
RPGRIP1-like
chr2_-_203736334 1.44 ENST00000392237.2
ENST00000416760.1
ENST00000412210.1
ICA1L
islet cell autoantigen 1,69kDa-like
chrX_+_107069063 1.42 ENST00000262843.6
MID2
midline 2
chr17_+_45286387 1.37 ENST00000572316.1
ENST00000354968.1
ENST00000576874.1
ENST00000536623.2
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr17_+_79495397 1.33 ENST00000417245.2
ENST00000334850.7
FSCN2
fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)
chr6_+_28493666 1.30 ENST00000412168.2
GPX5
glutathione peroxidase 5 (epididymal androgen-related protein)
chr22_-_24126145 1.27 ENST00000598975.1
AP000349.1
Uncharacterized protein
chr19_+_9434841 1.21 ENST00000446085.4
ENST00000603656.1
ENST00000541595.2
ENST00000592504.1
ENST00000585352.1
ENST00000317221.7
ENST00000586255.1
ENST00000592896.1
ENST00000605750.1
ENST00000603380.1
ENST00000538743.1
ENST00000589208.1
ENST00000592298.1
ENST00000585377.1
ENST00000393883.2
ENST00000588124.1
ENST00000602738.1
ZNF177
ZNF559
ZNF177
ZNF559-ZNF177 readthrough
zinc finger protein 559
zinc finger protein 177
chr1_+_154966058 1.18 ENST00000392487.1
LENEP
lens epithelial protein
chr11_-_3692597 1.09 ENST00000534359.1
ENST00000250699.2
CHRNA10
cholinergic receptor, nicotinic, alpha 10 (neuronal)
chr11_-_64889529 1.05 ENST00000531743.1
ENST00000527548.1
ENST00000526555.1
ENST00000279259.3
FAU
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
chr11_-_36619771 1.02 ENST00000311485.3
ENST00000527033.1
ENST00000532616.1
RAG2
recombination activating gene 2
chr3_-_10452359 0.99 ENST00000452124.1
ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr16_+_23765948 0.99 ENST00000300113.2
CHP2
calcineurin-like EF-hand protein 2
chr9_+_71944241 0.98 ENST00000257515.8
FAM189A2
family with sequence similarity 189, member A2
chr19_-_9649253 0.86 ENST00000593003.1
ZNF426
zinc finger protein 426
chr8_-_102181718 0.86 ENST00000565617.1
KB-1460A1.5
KB-1460A1.5
chr5_+_7396141 0.84 ENST00000338316.4
ADCY2
adenylate cyclase 2 (brain)
chr11_+_102188272 0.84 ENST00000532808.1
BIRC3
baculoviral IAP repeat containing 3
chr19_-_9649303 0.81 ENST00000253115.2
ZNF426
zinc finger protein 426
chr9_+_116267536 0.77 ENST00000374136.1
RGS3
regulator of G-protein signaling 3
chr22_-_32058166 0.68 ENST00000435900.1
ENST00000336566.4
PISD
phosphatidylserine decarboxylase
chr6_+_28493753 0.67 ENST00000469384.1
GPX5
glutathione peroxidase 5 (epididymal androgen-related protein)
chr8_-_119964434 0.59 ENST00000297350.4
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr15_+_84904525 0.50 ENST00000510439.2
GOLGA6L4
golgin A6 family-like 4
chr19_+_55043977 0.48 ENST00000335056.3
KIR3DX1
killer cell immunoglobulin-like receptor, three domains, X1
chr16_-_1821496 0.37 ENST00000564628.1
ENST00000563498.1
NME3
NME/NM23 nucleoside diphosphate kinase 3
chr1_-_233431458 0.30 ENST00000258229.9
ENST00000430153.1
PCNXL2
pecanex-like 2 (Drosophila)
chr1_+_15986364 0.21 ENST00000345034.1
RSC1A1
regulatory solute carrier protein, family 1, member 1
chr17_+_37824700 0.21 ENST00000581428.1
PNMT
phenylethanolamine N-methyltransferase
chr9_+_135854091 0.17 ENST00000450530.1
ENST00000534944.1
GFI1B
growth factor independent 1B transcription repressor
chr19_-_51472222 0.14 ENST00000376851.3
KLK6
kallikrein-related peptidase 6

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF691

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 11.0 GO:2000537 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
2.6 7.9 GO:0045645 regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645)
2.6 7.8 GO:0052056 modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
2.4 50.8 GO:0097320 membrane tubulation(GO:0097320)
2.3 7.0 GO:1902997 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
1.4 4.1 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
1.3 9.3 GO:0039663 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
1.1 6.5 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.7 3.0 GO:0060825 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
0.7 5.2 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.6 3.7 GO:0038161 prolactin signaling pathway(GO:0038161)
0.6 3.6 GO:0001692 histamine metabolic process(GO:0001692)
0.6 8.4 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.5 18.4 GO:0045730 respiratory burst(GO:0045730)
0.5 5.9 GO:0042355 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.5 4.7 GO:0015889 cobalamin transport(GO:0015889)
0.4 4.0 GO:0035799 ureter maturation(GO:0035799)
0.4 2.4 GO:1901098 regulation of autophagosome maturation(GO:1901096) positive regulation of autophagosome maturation(GO:1901098)
0.4 1.5 GO:0001757 somite specification(GO:0001757) sclerotome development(GO:0061056)
0.4 1.4 GO:2000768 glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
0.4 2.2 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.3 1.7 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.3 6.5 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.3 1.0 GO:0002331 pre-B cell differentiation(GO:0002329) pre-B cell allelic exclusion(GO:0002331)
0.2 16.4 GO:0006910 phagocytosis, recognition(GO:0006910)
0.2 4.2 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.2 3.4 GO:0021670 lateral ventricle development(GO:0021670)
0.2 2.2 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.2 5.8 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.2 1.1 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.1 0.6 GO:0042483 negative regulation of odontogenesis(GO:0042483)
0.1 3.0 GO:0016180 snRNA processing(GO:0016180)
0.1 14.2 GO:0050672 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.1 2.3 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1 2.9 GO:0045332 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.1 1.8 GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241)
0.1 4.4 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 0.8 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
0.1 1.5 GO:0002021 response to dietary excess(GO:0002021)
0.1 3.4 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 1.0 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 3.2 GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423)
0.1 2.8 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 0.8 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.1 5.5 GO:0042100 B cell proliferation(GO:0042100)
0.1 2.1 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.1 1.6 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 5.4 GO:0061045 negative regulation of wound healing(GO:0061045)
0.1 0.2 GO:0042418 epinephrine biosynthetic process(GO:0042418)
0.1 3.4 GO:0051155 positive regulation of striated muscle cell differentiation(GO:0051155)
0.0 1.4 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.0 3.3 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 1.3 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 2.4 GO:0090303 positive regulation of wound healing(GO:0090303)
0.0 1.8 GO:0030593 neutrophil chemotaxis(GO:0030593)
0.0 3.8 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 4.2 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 0.4 GO:0006228 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.0 25.2 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 1.7 GO:2000273 positive regulation of receptor activity(GO:2000273)
0.0 5.6 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 2.0 GO:0098869 cellular oxidant detoxification(GO:0098869)
0.0 2.0 GO:0006405 RNA export from nucleus(GO:0006405)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 50.8 GO:0001891 phagocytic cup(GO:0001891)
1.3 6.5 GO:0071797 LUBAC complex(GO:0071797)
1.1 3.4 GO:0005879 axonemal microtubule(GO:0005879)
1.1 9.9 GO:0005638 lamin filament(GO:0005638)
0.7 11.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.5 7.0 GO:0005641 nuclear envelope lumen(GO:0005641)
0.4 7.8 GO:0097342 ripoptosome(GO:0097342)
0.4 4.2 GO:0060077 inhibitory synapse(GO:0060077)
0.3 3.0 GO:0032039 integrator complex(GO:0032039)
0.3 16.4 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.2 3.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.2 2.3 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.2 2.0 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.2 2.0 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 20.2 GO:0031225 anchored component of membrane(GO:0031225)
0.1 2.4 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 5.9 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 1.4 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 2.8 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 2.1 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.1 5.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 4.7 GO:0031526 brush border membrane(GO:0031526)
0.1 1.8 GO:0098636 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 3.0 GO:0031904 endosome lumen(GO:0031904)
0.1 13.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.1 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 1.7 GO:0016592 mediator complex(GO:0016592)
0.0 1.8 GO:0005902 microvillus(GO:0005902)
0.0 1.3 GO:0032420 stereocilium(GO:0032420)
0.0 0.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 3.3 GO:0005776 autophagosome(GO:0005776)
0.0 6.5 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 6.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.7 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 4.1 GO:0032993 protein-DNA complex(GO:0032993)
0.0 1.4 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.6 GO:0005923 bicellular tight junction(GO:0005923)
0.0 3.4 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 2.6 GO:0043235 receptor complex(GO:0043235)
0.0 16.8 GO:0005615 extracellular space(GO:0005615)
0.0 2.6 GO:0048471 perinuclear region of cytoplasm(GO:0048471)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 11.0 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
2.6 7.9 GO:0005137 interleukin-5 receptor binding(GO:0005137)
1.6 7.8 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
1.2 5.9 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.7 3.7 GO:0004925 prolactin receptor activity(GO:0004925)
0.7 9.3 GO:0019957 C-C chemokine binding(GO:0019957)
0.6 8.4 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.6 2.3 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.5 2.6 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.4 7.0 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.4 1.7 GO:0030375 thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)
0.4 6.5 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.4 9.9 GO:0005521 lamin binding(GO:0005521)
0.3 1.4 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.3 4.0 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.3 16.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.2 3.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.2 0.7 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
0.2 5.5 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.1 6.5 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 2.2 GO:0038191 neuropilin binding(GO:0038191)
0.1 6.0 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 4.4 GO:0005504 fatty acid binding(GO:0005504)
0.1 2.9 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 50.8 GO:0005543 phospholipid binding(GO:0005543)
0.1 4.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 29.3 GO:0005096 GTPase activator activity(GO:0005096)
0.1 1.5 GO:0071837 HMG box domain binding(GO:0071837)
0.1 2.0 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 2.1 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1 0.2 GO:0004603 phenylethanolamine N-methyltransferase activity(GO:0004603)
0.1 2.0 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 4.1 GO:0070888 E-box binding(GO:0070888)
0.1 2.4 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 0.8 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 2.6 GO:0042169 SH2 domain binding(GO:0042169)
0.1 2.4 GO:0005158 insulin receptor binding(GO:0005158)
0.1 1.8 GO:0043236 laminin binding(GO:0043236)
0.1 5.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.1 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 1.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.0 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 1.8 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 2.8 GO:0051082 unfolded protein binding(GO:0051082)
0.0 1.7 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 1.9 GO:0005179 hormone activity(GO:0005179)
0.0 1.7 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.4 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.6 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 1.3 GO:0051015 actin filament binding(GO:0051015)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 11.0 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.3 7.9 PID IL5 PATHWAY IL5-mediated signaling events
0.3 8.6 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.2 5.2 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 9.3 PID IL12 2PATHWAY IL12-mediated signaling events
0.1 3.2 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 4.5 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 2.1 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 1.8 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.8 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 4.1 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.3 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.8 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 9.3 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.6 11.0 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.3 11.0 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.3 6.5 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.2 7.9 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.2 4.7 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 3.7 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 25.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 5.2 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.1 4.1 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 2.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 3.9 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 5.9 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 2.1 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 1.6 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 1.8 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.0 5.8 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 2.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.8 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.8 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 1.4 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.8 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 1.7 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.1 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 4.5 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway