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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ZNF711_TFAP2A_TFAP2D
Z-value: 1.32
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Transcription factors associated with ZNF711_TFAP2A_TFAP2D
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000147180.12 | zinc finger protein 711 | |
| ENSG00000137203.6 | transcription factor AP-2 alpha | |
| ENSG00000008197.4 | transcription factor AP-2 delta |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF711 | hg19_v2_chrX_+_84499081_84499115, hg19_v2_chrX_+_84498989_84499003, hg19_v2_chrX_+_84499038_84499078 | -0.50 | 2.0e-15 | Click! |
| TFAP2A | hg19_v2_chr6_-_10415470_10415508 | 0.28 | 2.0e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF711_TFAP2A_TFAP2D
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 21.8 | 1892.4 | GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) |
| 11.7 | 1453.9 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 19.5 | 1441.6 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 10.3 | 1043.0 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 22.6 | 994.9 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 3.7 | 733.1 | GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 20.5 | 634.6 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
| 13.5 | 634.5 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 12.7 | 633.1 | GO:0006378 | mRNA polyadenylation(GO:0006378) |
| 18.4 | 588.6 | GO:0070911 | global genome nucleotide-excision repair(GO:0070911) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 3225.7 | GO:0070062 | extracellular exosome(GO:0070062) |
| 5.4 | 2375.4 | GO:0005925 | focal adhesion(GO:0005925) |
| 10.1 | 1488.8 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 9.4 | 1488.2 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 12.2 | 1327.7 | GO:0015934 | large ribosomal subunit(GO:0015934) |
| 17.1 | 908.2 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 19.9 | 756.5 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 23.4 | 748.2 | GO:0022624 | proteasome accessory complex(GO:0022624) |
| 6.5 | 735.6 | GO:0016605 | PML body(GO:0016605) |
| 8.3 | 728.5 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 3960.4 | GO:0003723 | RNA binding(GO:0003723) |
| 8.3 | 3263.5 | GO:0045296 | cadherin binding(GO:0045296) |
| 13.6 | 2727.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 27.8 | 1279.3 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 27.3 | 818.2 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 20.5 | 736.5 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 11.8 | 670.8 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 14.0 | 645.2 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 33.3 | 599.2 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 1.7 | 598.8 | GO:0003712 | transcription cofactor activity(GO:0003712) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.0 | 2034.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 12.4 | 955.6 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 9.3 | 895.4 | PID E2F PATHWAY | E2F transcription factor network |
| 16.4 | 852.7 | PID BARD1 PATHWAY | BARD1 signaling events |
| 7.7 | 724.7 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 4.0 | 631.7 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 9.8 | 565.6 | PID AURORA B PATHWAY | Aurora B signaling |
| 10.0 | 500.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 5.5 | 458.1 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 13.7 | 453.6 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.5 | 3620.9 | REACTOME TRANSLATION | Genes involved in Translation |
| 27.3 | 2125.8 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 11.8 | 1442.3 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 8.3 | 1299.2 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 29.6 | 1007.4 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 15.3 | 951.2 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 9.8 | 852.2 | REACTOME MITOTIC M M G1 PHASES | Genes involved in Mitotic M-M/G1 phases |
| 17.1 | 801.6 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 18.6 | 724.7 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 8.4 | 673.1 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |