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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ZNF8
Z-value: 0.85
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Transcription factors associated with ZNF8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF8 | hg19_v2_chr19_+_58790314_58790358 | -0.56 | 3.6e-19 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_46662772 Show fit | 27.10 |
ENST00000549049.1
ENST00000439706.1 ENST00000398637.5 |
solute carrier family 38, member 1 |
|
| chr14_+_51706886 Show fit | 14.62 |
ENST00000457354.2
|
thioredoxin-related transmembrane protein 1 |
|
| chr7_+_100303676 Show fit | 13.28 |
ENST00000303151.4
|
processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) |
|
| chr7_-_99698338 Show fit | 10.00 |
ENST00000354230.3
ENST00000425308.1 |
minichromosome maintenance complex component 7 |
|
| chr1_-_70671216 Show fit | 9.67 |
ENST00000370952.3
|
leucine rich repeat containing 40 |
|
| chr1_-_235292250 Show fit | 9.09 |
ENST00000366607.4
|
translocase of outer mitochondrial membrane 20 homolog (yeast) |
|
| chr10_+_1034646 Show fit | 7.66 |
ENST00000360059.5
ENST00000545048.1 |
GTP binding protein 4 |
|
| chr11_+_69455855 Show fit | 7.56 |
ENST00000227507.2
ENST00000536559.1 |
cyclin D1 |
|
| chr4_-_77069573 Show fit | 7.49 |
ENST00000264883.3
|
nucleoporin 54kDa |
|
| chr6_+_29691056 Show fit | 7.37 |
ENST00000414333.1
ENST00000334668.4 ENST00000259951.7 |
major histocompatibility complex, class I, F |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF8
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 27.1 | GO:0015804 | neutral amino acid transport(GO:0015804) |
| 4.6 | 23.2 | GO:0009439 | cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440) |
| 0.2 | 14.6 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 1.4 | 14.4 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 0.7 | 13.3 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
| 2.2 | 10.8 | GO:1904274 | tricellular tight junction assembly(GO:1904274) |
| 0.1 | 10.5 | GO:0006406 | mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427) |
| 1.0 | 10.0 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 3.0 | 9.1 | GO:0035927 | RNA import into mitochondrion(GO:0035927) |
| 2.8 | 8.4 | GO:0033341 | regulation of collagen binding(GO:0033341) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 25.9 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 1.3 | 14.4 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 1.9 | 13.3 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
| 0.0 | 12.3 | GO:0043005 | neuron projection(GO:0043005) |
| 1.0 | 11.2 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 1.8 | 10.8 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.8 | 10.0 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 9.3 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 1.3 | 9.1 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.0 | 8.4 | GO:0031965 | nuclear membrane(GO:0031965) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 27.1 | GO:0005283 | sodium:amino acid symporter activity(GO:0005283) |
| 4.7 | 18.7 | GO:0016784 | 3-mercaptopyruvate sulfurtransferase activity(GO:0016784) |
| 0.7 | 14.6 | GO:0003756 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 2.4 | 14.4 | GO:0046979 | TAP2 binding(GO:0046979) |
| 0.8 | 13.3 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 0.0 | 10.4 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.2 | 10.0 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.9 | 9.1 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
| 0.2 | 7.6 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.3 | 7.5 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.0 | PID ATR PATHWAY | ATR signaling pathway |
| 0.4 | 7.6 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 6.7 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 2.9 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 1.4 | PID GMCSF PATHWAY | GMCSF-mediated signaling events |
| 0.0 | 1.3 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 1.2 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 1.2 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 27.1 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.2 | 14.9 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 1.4 | 14.4 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.6 | 10.0 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.3 | 7.6 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.2 | 7.5 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.1 | 6.7 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 5.4 | REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | Genes involved in Transport of Mature Transcript to Cytoplasm |
| 0.1 | 4.5 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 2.6 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |