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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for ZNF8

Z-value: 0.85

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Transcription factors associated with ZNF8

Gene Symbol Gene ID Gene Info
ZNF8
ENSG00000083842.8 zinc finger protein 8
ZNF8
ENSG00000273439.1 zinc finger protein 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF8hg19_v2_chr19_+_58790314_58790358-0.563.6e-19Click!

Activity profile of ZNF8 motif

Sorted Z-values of ZNF8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_46662772 27.10 ENST00000549049.1
ENST00000439706.1
ENST00000398637.5
SLC38A1
solute carrier family 38, member 1
chr14_+_51706886 14.62 ENST00000457354.2
TMX1
thioredoxin-related transmembrane protein 1
chr7_+_100303676 13.28 ENST00000303151.4
POP7
processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)
chr7_-_99698338 10.00 ENST00000354230.3
ENST00000425308.1
MCM7
minichromosome maintenance complex component 7
chr1_-_70671216 9.67 ENST00000370952.3
LRRC40
leucine rich repeat containing 40
chr1_-_235292250 9.09 ENST00000366607.4
TOMM20
translocase of outer mitochondrial membrane 20 homolog (yeast)
chr10_+_1034646 7.66 ENST00000360059.5
ENST00000545048.1
GTPBP4
GTP binding protein 4
chr11_+_69455855 7.56 ENST00000227507.2
ENST00000536559.1
CCND1
cyclin D1
chr4_-_77069573 7.49 ENST00000264883.3
NUP54
nucleoporin 54kDa
chr6_+_29691056 7.37 ENST00000414333.1
ENST00000334668.4
ENST00000259951.7
HLA-F
major histocompatibility complex, class I, F
chr16_+_21964662 7.11 ENST00000561553.1
ENST00000565331.1
UQCRC2
ubiquinol-cytochrome c reductase core protein II
chr6_+_29691198 7.02 ENST00000440587.2
ENST00000434407.2
HLA-F
major histocompatibility complex, class I, F
chr2_+_198365122 6.75 ENST00000604458.1
HSPE1-MOB4
HSPE1-MOB4 readthrough
chr8_-_109260897 6.74 ENST00000521297.1
ENST00000519030.1
ENST00000521440.1
ENST00000518345.1
ENST00000519627.1
ENST00000220849.5
EIF3E
eukaryotic translation initiation factor 3, subunit E
chr12_+_52463751 6.68 ENST00000336854.4
ENST00000550604.1
ENST00000553049.1
ENST00000548915.1
C12orf44
chromosome 12 open reading frame 44
chr13_+_53029564 6.33 ENST00000468284.1
ENST00000378034.3
ENST00000258607.5
ENST00000378037.5
CKAP2
cytoskeleton associated protein 2
chr6_+_106959718 6.30 ENST00000369066.3
AIM1
absent in melanoma 1
chr5_-_137911049 5.81 ENST00000297185.3
HSPA9
heat shock 70kDa protein 9 (mortalin)
chr1_+_186344945 5.59 ENST00000419367.3
ENST00000287859.6
C1orf27
chromosome 1 open reading frame 27
chr19_+_35739782 5.58 ENST00000347609.4
LSR
lipolysis stimulated lipoprotein receptor
chr1_+_70671363 5.45 ENST00000370951.1
ENST00000370950.3
ENST00000405432.1
ENST00000454435.2
SRSF11
serine/arginine-rich splicing factor 11
chr19_+_35739897 5.27 ENST00000605618.1
ENST00000427250.1
ENST00000601623.1
LSR
lipolysis stimulated lipoprotein receptor
chr22_+_37415676 5.23 ENST00000401419.3
MPST
mercaptopyruvate sulfurtransferase
chr1_+_186344883 5.13 ENST00000367470.3
C1orf27
chromosome 1 open reading frame 27
chrX_+_129535937 5.08 ENST00000305536.6
ENST00000370947.1
RBMX2
RNA binding motif protein, X-linked 2
chr7_+_117824086 4.83 ENST00000249299.2
ENST00000424702.1
NAA38
N(alpha)-acetyltransferase 38, NatC auxiliary subunit
chr22_+_37415728 4.71 ENST00000404802.3
MPST
mercaptopyruvate sulfurtransferase
chr1_-_246670519 4.68 ENST00000388985.4
ENST00000490107.1
SMYD3
SET and MYND domain containing 3
chr22_+_37415776 4.66 ENST00000341116.3
ENST00000429360.2
ENST00000404393.1
MPST
mercaptopyruvate sulfurtransferase
chr22_-_37415475 4.45 ENST00000403892.3
ENST00000249042.3
ENST00000438203.1
TST
thiosulfate sulfurtransferase (rhodanese)
chr5_+_10353780 4.39 ENST00000449913.2
ENST00000503788.1
ENST00000274140.5
MARCH6
membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
chr22_+_37415700 4.14 ENST00000397129.1
MPST
mercaptopyruvate sulfurtransferase
chr22_+_30163340 4.11 ENST00000330029.6
ENST00000401406.3
UQCR10
ubiquinol-cytochrome c reductase, complex III subunit X
chr11_-_58345569 3.92 ENST00000528954.1
ENST00000528489.1
LPXN
leupaxin
chr11_-_61560254 3.31 ENST00000543510.1
TMEM258
transmembrane protein 258
chr11_+_46402583 3.13 ENST00000359803.3
MDK
midkine (neurite growth-promoting factor 2)
chr19_-_18392422 2.90 ENST00000252818.3
JUND
jun D proto-oncogene
chr2_+_87144738 2.62 ENST00000559485.1
RGPD1
RANBP2-like and GRIP domain containing 1
chr15_+_85523671 2.61 ENST00000310298.4
ENST00000557957.1
PDE8A
phosphodiesterase 8A
chr6_-_26056695 2.32 ENST00000343677.2
HIST1H1C
histone cluster 1, H1c
chr1_+_25664408 2.31 ENST00000374358.4
TMEM50A
transmembrane protein 50A
chr1_+_211500129 2.25 ENST00000427925.2
ENST00000261464.5
TRAF5
TNF receptor-associated factor 5
chr13_+_45563721 2.20 ENST00000361121.2
GPALPP1
GPALPP motifs containing 1
chr4_-_186347099 2.06 ENST00000505357.1
ENST00000264689.6
UFSP2
UFM1-specific peptidase 2
chr8_+_61429416 2.01 ENST00000262646.7
ENST00000531289.1
RAB2A
RAB2A, member RAS oncogene family
chr5_+_102455968 2.00 ENST00000358359.3
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr13_+_21750780 1.85 ENST00000309594.4
MRP63
mitochondrial ribosomal protein 63
chr19_-_55652290 1.83 ENST00000589745.1
TNNT1
troponin T type 1 (skeletal, slow)
chr17_+_48624450 1.61 ENST00000006658.6
ENST00000356488.4
ENST00000393244.3
SPATA20
spermatogenesis associated 20
chr4_+_170541660 1.44 ENST00000513761.1
ENST00000347613.4
CLCN3
chloride channel, voltage-sensitive 3
chrX_+_1387693 1.37 ENST00000381529.3
ENST00000432318.2
ENST00000361536.3
ENST00000501036.2
ENST00000381524.3
ENST00000412290.1
CSF2RA
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
chr2_-_105946491 1.35 ENST00000393359.2
TGFBRAP1
transforming growth factor, beta receptor associated protein 1
chr14_+_105941118 1.24 ENST00000550577.1
ENST00000538259.2
CRIP2
cysteine-rich protein 2
chrX_+_102631248 1.21 ENST00000361298.4
ENST00000372645.3
ENST00000372635.1
NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr17_+_75181292 0.96 ENST00000431431.2
SEC14L1
SEC14-like 1 (S. cerevisiae)
chr10_+_1034338 0.73 ENST00000360803.4
ENST00000538293.1
GTPBP4
GTP binding protein 4
chr7_-_74489609 0.61 ENST00000329959.4
ENST00000503250.2
ENST00000543840.1
WBSCR16
Williams-Beuren syndrome chromosome region 16
chr16_-_53537105 0.29 ENST00000568596.1
ENST00000570004.1
ENST00000564497.1
ENST00000300245.4
ENST00000394657.7
AKTIP
AKT interacting protein

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 23.2 GO:0009439 cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440)
3.0 9.1 GO:0035927 RNA import into mitochondrion(GO:0035927)
2.8 8.4 GO:0033341 regulation of collagen binding(GO:0033341)
2.2 10.8 GO:1904274 tricellular tight junction assembly(GO:1904274)
1.9 7.5 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
1.8 7.1 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
1.4 14.4 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
1.0 10.0 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.8 7.6 GO:0070141 response to UV-A(GO:0070141)
0.7 6.7 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.7 13.3 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.7 5.8 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.7 27.1 GO:0015804 neutral amino acid transport(GO:0015804)
0.5 4.1 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.5 3.9 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.3 2.3 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.2 1.8 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.2 1.2 GO:0030421 defecation(GO:0030421)
0.2 6.3 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.2 14.6 GO:0045454 cell redox homeostasis(GO:0045454)
0.2 4.4 GO:1904380 endoplasmic reticulum mannose trimming(GO:1904380)
0.1 1.3 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.1 2.0 GO:0006020 inositol metabolic process(GO:0006020)
0.1 4.7 GO:0071549 cellular response to dexamethasone stimulus(GO:0071549)
0.1 2.6 GO:0000042 protein targeting to Golgi(GO:0000042)
0.1 1.0 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.1 10.5 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.1 2.6 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 2.9 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 3.3 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 2.1 GO:0033146 regulation of intracellular estrogen receptor signaling pathway(GO:0033146)
0.0 6.7 GO:0006457 protein folding(GO:0006457)
0.0 2.0 GO:0007030 Golgi organization(GO:0007030)
0.0 2.2 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 13.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
1.8 10.8 GO:0061689 tricellular tight junction(GO:0061689)
1.3 14.4 GO:0042612 MHC class I protein complex(GO:0042612)
1.3 9.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
1.2 4.8 GO:0031417 NatC complex(GO:0031417)
1.0 11.2 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.8 10.0 GO:0042555 MCM complex(GO:0042555)
0.7 4.4 GO:0000835 ER ubiquitin ligase complex(GO:0000835)
0.4 7.5 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.4 2.9 GO:0035976 AP1 complex(GO:0035976)
0.3 3.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.3 6.7 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.3 1.3 GO:0033263 CORVET complex(GO:0033263)
0.2 5.1 GO:0005686 U2 snRNP(GO:0005686)
0.2 2.2 GO:0035631 CD40 receptor complex(GO:0035631)
0.1 7.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 6.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 2.3 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 1.8 GO:0005861 troponin complex(GO:0005861)
0.1 0.3 GO:0070695 FHF complex(GO:0070695)
0.1 3.9 GO:0002102 podosome(GO:0002102)
0.0 2.3 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 8.4 GO:0031965 nuclear membrane(GO:0031965)
0.0 2.0 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 25.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 12.3 GO:0043005 neuron projection(GO:0043005)
0.0 9.3 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 4.5 GO:0005759 mitochondrial matrix(GO:0005759)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 18.7 GO:0016784 3-mercaptopyruvate sulfurtransferase activity(GO:0016784)
2.4 14.4 GO:0046979 TAP2 binding(GO:0046979)
2.2 4.5 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
1.4 27.1 GO:0005283 sodium:amino acid symporter activity(GO:0005283)
0.9 9.1 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.8 13.3 GO:0004526 ribonuclease P activity(GO:0004526)
0.7 14.6 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.6 4.1 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.5 4.7 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.4 2.0 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.4 4.4 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.3 7.5 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.2 7.6 GO:0070064 proline-rich region binding(GO:0070064)
0.2 10.0 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.2 1.0 GO:0039552 RIG-I binding(GO:0039552)
0.1 2.2 GO:0031996 thioesterase binding(GO:0031996)
0.1 1.8 GO:0031014 troponin T binding(GO:0031014)
0.1 6.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 2.6 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 2.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 2.1 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.1 7.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 5.8 GO:0051082 unfolded protein binding(GO:0051082)
0.0 10.4 GO:0003924 GTPase activity(GO:0003924)
0.0 1.3 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 2.3 GO:0031490 chromatin DNA binding(GO:0031490)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.6 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 10.0 PID ATR PATHWAY ATR signaling pathway
0.1 6.7 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 2.9 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.3 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.4 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.0 1.2 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 1.2 PID P75 NTR PATHWAY p75(NTR)-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 14.4 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.7 27.1 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.6 10.0 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.3 7.6 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.2 14.9 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.2 7.5 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.1 5.4 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.1 2.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 4.5 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 6.7 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.4 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 2.3 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.8 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.2 REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.0 2.6 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events