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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ZSCAN4
Z-value: 0.08
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Transcription factors associated with ZSCAN4
Network of associatons between targets according to the STRING database.
First level regulatory network of ZSCAN4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 17.9 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 1.0 | 15.4 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.1 | 10.9 | GO:0002433 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) |
| 0.2 | 10.6 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 0.9 | 10.5 | GO:0043951 | negative regulation of cAMP-mediated signaling(GO:0043951) |
| 3.2 | 9.7 | GO:0035408 | histone H3-T6 phosphorylation(GO:0035408) |
| 1.4 | 8.2 | GO:2001181 | positive regulation of interleukin-10 secretion(GO:2001181) |
| 0.1 | 7.3 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 2.3 | 7.0 | GO:1900368 | regulation of RNA interference(GO:1900368) negative regulation of RNA interference(GO:1900369) |
| 0.0 | 6.5 | GO:0001558 | regulation of cell growth(GO:0001558) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 21.9 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 20.3 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 15.4 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 13.9 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.2 | 10.6 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 9.4 | GO:0005769 | early endosome(GO:0005769) |
| 1.0 | 8.2 | GO:0045179 | apical cortex(GO:0045179) |
| 0.1 | 8.0 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 7.6 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 1.4 | 7.0 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 28.2 | GO:0019864 | IgG binding(GO:0019864) |
| 0.0 | 11.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.2 | 10.6 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 3.2 | 9.7 | GO:0035403 | histone kinase activity (H3-T6 specific)(GO:0035403) |
| 0.4 | 8.2 | GO:0043560 | insulin receptor substrate binding(GO:0043560) |
| 0.0 | 7.6 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.1 | 7.3 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 1.8 | 7.0 | GO:0003726 | double-stranded RNA adenosine deaminase activity(GO:0003726) |
| 0.3 | 5.8 | GO:0005537 | mannose binding(GO:0005537) |
| 0.5 | 5.0 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.5 | 15.5 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 10.6 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.4 | 9.7 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.2 | 8.2 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 5.6 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.3 | 5.1 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.0 | 4.8 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.1 | 3.2 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 2.5 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.0 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.3 | 11.7 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.3 | 9.7 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.1 | 8.3 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.3 | 8.2 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.2 | 7.2 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.1 | 7.0 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 6.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 5.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.7 | 5.0 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |