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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for AACCUGG

Z-value: 0.18

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miRNA associated with seed AACCUGG

NamemiRBASE accession
hsa-miR-490-3p
MIMAT0002806

Activity profile of AACCUGG motif

Sorted Z-values of AACCUGG motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_+_123095155 2.38 ENST00000371160.1
ENST00000435103.1
STAG2
stromal antigen 2
chr19_+_34919257 1.35 ENST00000246548.4
ENST00000590048.2
UBA2
ubiquitin-like modifier activating enzyme 2
chr1_+_93811438 1.32 ENST00000370272.4
ENST00000370267.1
DR1
down-regulator of transcription 1, TBP-binding (negative cofactor 2)
chr8_-_103876965 1.23 ENST00000337198.5
AZIN1
antizyme inhibitor 1
chr7_-_26240357 1.06 ENST00000354667.4
ENST00000356674.7
HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr1_+_193091080 0.96 ENST00000367435.3
CDC73
cell division cycle 73
chr11_+_125462690 0.96 ENST00000392708.4
ENST00000529196.1
ENST00000531491.1
STT3A
STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
chr14_+_57735614 0.90 ENST00000261558.3
AP5M1
adaptor-related protein complex 5, mu 1 subunit
chr12_-_123011536 0.87 ENST00000331738.7
ENST00000354654.2
RSRC2
arginine/serine-rich coiled-coil 2
chr8_-_17104356 0.81 ENST00000361272.4
ENST00000523917.1
CNOT7
CCR4-NOT transcription complex, subunit 7
chr3_-_189838670 0.72 ENST00000319332.5
LEPREL1
leprecan-like 1
chr7_+_77166592 0.66 ENST00000248594.6
PTPN12
protein tyrosine phosphatase, non-receptor type 12
chr7_+_100797678 0.62 ENST00000337619.5
AP1S1
adaptor-related protein complex 1, sigma 1 subunit
chr17_+_30677136 0.58 ENST00000394670.4
ENST00000321233.6
ENST00000394673.2
ENST00000341711.6
ENST00000579634.1
ENST00000580759.1
ENST00000342555.6
ENST00000577908.1
ENST00000394679.5
ENST00000582165.1
ZNF207
zinc finger protein 207
chr8_-_68255912 0.57 ENST00000262215.3
ENST00000519436.1
ARFGEF1
ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
chr11_+_63706444 0.55 ENST00000377793.4
ENST00000456907.2
ENST00000539656.1
NAA40
N(alpha)-acetyltransferase 40, NatD catalytic subunit
chr2_+_178077477 0.54 ENST00000411529.2
ENST00000435711.1
HNRNPA3
heterogeneous nuclear ribonucleoprotein A3
chr1_-_247094628 0.54 ENST00000366508.1
ENST00000326225.3
ENST00000391829.2
AHCTF1
AT hook containing transcription factor 1
chr4_+_184020398 0.43 ENST00000403733.3
ENST00000378925.3
WWC2
WW and C2 domain containing 2
chr12_+_67663056 0.36 ENST00000545606.1
CAND1
cullin-associated and neddylation-dissociated 1
chr11_+_125439298 0.30 ENST00000278903.6
ENST00000343678.4
ENST00000524723.1
ENST00000527842.2
EI24
etoposide induced 2.4
chr5_+_109025067 0.30 ENST00000261483.4
MAN2A1
mannosidase, alpha, class 2A, member 1
chr17_-_48785216 0.26 ENST00000285243.6
ANKRD40
ankyrin repeat domain 40
chrX_+_9983602 0.25 ENST00000380861.4
WWC3
WWC family member 3
chr9_-_123964114 0.23 ENST00000373840.4
RAB14
RAB14, member RAS oncogene family
chr15_+_52121822 0.18 ENST00000558455.1
ENST00000308580.7
TMOD3
tropomodulin 3 (ubiquitous)
chr14_-_25519095 0.17 ENST00000419632.2
ENST00000358326.2
ENST00000396700.1
ENST00000548724.1
STXBP6
syntaxin binding protein 6 (amisyn)
chr17_-_1303462 0.16 ENST00000573026.1
ENST00000575977.1
ENST00000571732.1
ENST00000264335.8
YWHAE
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
chr9_-_38069208 0.09 ENST00000377707.3
ENST00000377700.4
SHB
Src homology 2 domain containing adaptor protein B
chr6_-_91006461 0.02 ENST00000257749.4
ENST00000343122.3
ENST00000406998.2
ENST00000453877.1
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2

Network of associatons between targets according to the STRING database.

First level regulatory network of AACCUGG

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.2 2.4 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.2 1.1 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.2 0.6 GO:0090283 regulation of protein glycosylation in Golgi(GO:0090283)
0.1 0.8 GO:0060339 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.1 0.7 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 1.0 GO:0001711 endodermal cell fate commitment(GO:0001711)
0.1 0.7 GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.1 0.2 GO:1902309 regulation of heart rate by hormone(GO:0003064) negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0 0.3 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.4 GO:0010265 SCF complex assembly(GO:0010265)
0.0 0.5 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.5 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.0 0.1 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 0.2 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 1.0 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 1.3 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 0.6 GO:0071173 mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)
0.0 0.6 GO:0050690 regulation of defense response to virus by virus(GO:0050690)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.2 0.8 GO:0044094 host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.1 1.0 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.1 0.6 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 1.0 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 0.3 GO:0005797 Golgi medial cisterna(GO:0005797)
0.1 1.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.9 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 1.1 GO:0015030 Cajal body(GO:0015030)
0.0 3.0 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 0.7 GO:0002102 podosome(GO:0002102)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.2 1.4 GO:0044388 small protein activating enzyme binding(GO:0044388)
0.1 1.1 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.1 0.5 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189)
0.1 1.0 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 0.5 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0 0.7 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.8 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 1.7 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 1.0 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.6 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.3 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.2 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.3 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.4 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 2.9 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.8 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.2 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.3 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.0 1.6 REACTOME MRNA SPLICING Genes involved in mRNA Splicing